Amazwana: Ukutadisha kuhlolwe amakhemikhali amaningi we-neurochemicals kanye nama-proteine abandakanyeka ekulutha izidakamizwa. Ukutadisha kutholakale izinguquko ezifanayo ezihambisana nokuziphatha okufanayo kumagundane lapho kudliwe ngokudla okunamafutha aphezulu kakhulu.
I-Int J Obes (Lond). I-2012 Dec 11. i-doi: 10.1038 / ijo.2012.197.
I-Sharma S, Fernandes MF, Fulton S.
Umthombo
I-CRCHUM ne-Montreal Research Diabetes Center; UMnyango Wokudla, I-Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
abstract
Injongo:
Ukuthola izinqubo zokucindezeleka ezingokomzwelo nezishukumisayo ezibuyisela ukudla okunomsoco ngokulandela ukususwa kokudla okunamafutha amaningi (HFD) kanye nama-neuroadaptations ahlotshaniswe nezibopho ze-neurochemical nezokuziphatha ezisekelwe ngaphansi kwe-dopaminergic function.
Izindlela:
Amadoda amadala ama-C57Bl6 amagundane thinakufakwa kwi-HFD (i-58% kcal fat) noma isithako esifanelwe, ukudla okunamafutha aphansi (i-LFD; i-11% kcal fat) yamaviki e-6. Ekupheleni kokudla-izigulane kwakungagcinwa ngezidlo zabo, noma i-HFD ne-LFD zishintshwa ngokuchotshozwa okujwayelekile (ukuhoxiswa).
Ukuphendula okusebenzayo okusebenza ngokuzikhandla kwe-sucrose kanye nemivuzo yokudla kwamafutha aphezulu kwakulinganiswa kanye namazinga ase-coralosterone aphethwe ngokucindezeleka nokucindezeleka (maze-plus plus maze). Amaprotheni amazinga we-tyrosine hydroxylase (TH), i-corticosterone ekhishwa uhlobo lwe-factor 1 receptor (CRF-R1), i-neurotrophic factor (i-BDNF) etholakala ebuchosheni, i-phospho-CREB (pCREB) ne-ΔFosB (i-spybated splice ehlukile ye-FosB) yahlolwa ku-amygdala , i-nucleus accumbens (NAc) ne-ventral tegmental (VTA) nge-western immunoblotting.
Ezenye:
Amaviki ayisithupha we-HFD okuholela ekuzuzeni okunomzimba obuningi okwenziwe isisindo esiphuthumayo kuqukethe i-sucrose anhedonia, ukuziphatha okukhathazayo-kanye ne-hypothalamic-pituitary-adrenocortical axis (HPA) yokucindezela ukucindezeleka. Ukuhoxiswa kusuka ku-HFD kodwa hhayi i-LFD-amazinga okukhathazeka kanye namazinga ase-corticosterone esisekelo kanye nesisusa esithuthukisiwe se-sucrose kanye nemivuzo yokudla kwamafutha aphezulu.
Ukudla okunomsoco okuphezulu okunciphisa ama-CRF-R1 nokwandisa ama-BDNF nama-pCREB amaprotheni amazinga amygdala futhi anciphisa TH futhi ukwandisa i-ΔFosB amaprotheni ku-NAc ne-VTA. Umvuzo wokudla okunomsoco okhushulwayo kumagundane ohoxisiwe kusuka ku-HFD uhambelana namazinga eeprotheni e-BDNF okwandisiwe ku-NAc futhi wehla ukukhuluma kwe-TH ne-PCREB ku-amygdala.
Isiphetho:
I-Anhedonia, ukukhathazeka nokuzwela kokucindezeleka kuqhubeka ngesikhathi se-HFD futhi ingaba nendima ebalulekile emjikelezweni ononya oqhubekayo nokudla okunamafutha amaningi nokuthuthukiswa kokukhuluphala. Ukususwa kwe-HFD kuthuthukisa izimpendulo zokucindezeleka futhi kukhulise ubunzima bokudla okunomsoco ngokuthuthukisa ukuziphatha okukhuthazayo kokudla. Izinguquko ezihlala njalo embonini ye-dopamine kanye ne-plasticity emjikelezweni we-rewardry zingase zithuthukise izimo ezingokomzwelo ezimbi, ukudla nokudla okunomsoco okunomsoco.
I-International Journal of Obesity iqhubekela phambili encwadini ye-intanethi, i-11 December 2012; i-doi: 10.1038 / ijo.2012.197.
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