Eating ‘Junk-Food’ Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors; Implications for Enhanced Cue-Induced Motivation and Food Addiction (2016)

Neuropsychopharmacology. 2016 Jul 7. doi: 10.1038/npp.2016.111. Oginsky MF1, Goforth PB1, Nobile CW1, Lopez-Santiago L1, Ferrario CR1. Abstract Urges to eat are influenced by stimuli in the environment that are associated with food (food cues). Obese people are more sensitive to food cues, reporting stronger craving and consuming larger portions after food cue exposure. The nucleus […]

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Age 29 – Sex with my wife is better than it has ever been. Depression, anxiety, social abstinence, has all reversed

I’m 29, and there have been some amazing changes since my journey of rebooting. Here’s a are several good symptoms that have resulted from No porn or masturbation. 1. Sex with my wife is better than it has ever been in 8 years of marriage. To explain; I used to do exactly what turned me […]

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Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake (2006)

J Neurosci. 2006 Jul 5;26(27):7163-71. Le Merrer J1, Stephens DN. PMID: 16822973 DOI: 10.1523/JNEUROSCI.5345-05.2006 Abstract Repeated administration of abused drugs sensitizes their stimulant effects and results in a drug-paired environment eliciting conditioned activity. We tested whether food induces similar effects. Food-deprived male mice were given novel food during 30 min tests in a runway (FR […]

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When Chocolate Seeking Becomes Compulsion: Gene-Environment Interplay (2015)

Enrico Patrono , Matteo Di Segni , Loris Patella, Diego Andolina, Alessandro Valzania, Emanuele Claudio Latagliata, Armando Felsani, Assunta Pompili, Antonella Gasbarri, Stefano Puglisi-Allegra, Rossella Ventur Published: March 17, 2015 http://dx.doi.org/10.1371/journal.pone.0120191 Abstract Background Eating disorders appear to be caused by a complex interaction between environmental and genetic factors, and compulsive eating in response to adverse […]

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Transitionality in addiction: A “temporal continuum” hypotheses involving the aberrant motivation, the hedonic dysregulation, and the aberrant learning (2016)

Med Hypotheses. 2016 Aug;93:62-70. doi: 10.1016/j.mehy.2016.05.015. Patrono E1, Gasbarri A2, Tomaz C3, Nishijo H4. Article Outline Introduction The “incentive-sensitization” theory The “hedonic dysregulation” theory The “habit-based learning” theory A “temporal continuum” hypotheses involving the aberrant motivation, the hedonic dysregulation, and the aberrant learning Neuro-bio-physiological background of drug addiction “temporal continuum” hypotheses The neural basis of […]

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Rebooting my marriage in general, and our sex life: Sex is becoming something she looks forward to

Well, I’ve hit a 60 day milestone in being PMO-free. The first 30 days were very much focused on figuring out an effective path to discontinuing PMO, and the last 30 days I’ve been able to focus on rebooting my marriage – in general and our sex life. Before starting NoFap, I was on a […]

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