Age 25 – Sex feels amazing! Morning wood, Stay hard for much longer, Urges for a real connection

Like most of you I discovered online Porn in my early teens, I’m now 25 and single with 2 previous relationships. After having a realisation that I was litteraly only interested in sex, I decided it’s time to sort it out to get a emotional connection back as well as physical, and during this I […]

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The Role of the Glucocorticoids in Developing Resilience to Stress and Addiction (2013)

Front Psychiatry. 2013; 4: 68. Published online 2013 Aug 1. doi:  10.3389/fpsyt.2013.00068 PMCID: PMC3730062 Subhashini Srinivasan,1 Masroor Shariff,2 and Selena E. Bartlett2,* Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract There is emerging evidence that individuals have the capacity […]

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Orexin mediates initiation of sexual behavior in sexually naïve male rats, but is not critical for sexual performance (2011)

Horm Behav. Author manuscript; available in PMC 2011 Aug 1. Published in final edited form as: Horm Behav. 2010 Aug; 58(3): 397–404. Published online 2010 Jun 10. doi:  10.1016/j.yhbeh.2010.06.004 PMCID: PMC2917508 Andrea R. Di Sebastiano,1 Sabrina Yong-Yow,2 Lauren Wagner,3 Michael N. Lehman,1 and Lique M. Coolen1,2 Author information ► Copyright and License information ► The […]

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Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area (2014)

Proc Natl Acad Sci U S A v.111(16); 2014 Apr 22 Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16): E1648–E1655. Published online 2014 Mar 24. doi:  10.1073/pnas.1315542111 PMCID: PMC4000785 Neuroscience John W. Muschamp,a,1 Jonathan A. Hollander,b Jennifer L. Thompson,c George Voren,b Linda C. Hassinger,a Sara Onvani,a Theodore M. Kamenecka,b Stephanie L. Borgland,c […]

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The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior (2014)

Front Behav Neurosci. 2014; 8: 117. Published online 2014 Apr 3. doi:  10.3389/fnbeh.2014.00117 PMCID: PMC3982054 Alessandra Matzeu,* Eva R. Zamora-Martinez, and Rémi Martin-Fardon Author information ► Article notes ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract A major challenge for the successful treatment of […]

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Orexins in the regulation of the hypothalamic-pituitary-adrenal axis (2006)

Pharmacol Rev. 2006 Mar;58(1):46-57. Spinazzi R1, Andreis PG, Rossi GP, Nussdorfer GG. Abstract Orexin-A and orexin-B are hypothalamic peptides that act via two G protein-coupled receptors, named orexin type 1 and type 2 receptors (OX1-Rs and OX2-Rs). The most studied biological functions of orexins are the central control of feeding and sleep, but in the […]

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Orexin Receptors: Pharmacology and Therapeutic Opportunities (2012)

Annu Rev Pharmacol Toxicol. Author manuscript; available in PMC 2012 Feb 10. Published in final edited form as: Annu Rev Pharmacol Toxicol. 2011 Feb 10; 51: 243–266. doi:  10.1146/annurev-pharmtox-010510-100528 PMCID: PMC3058259 NIHMSID: NIHMS277744 Thomas E. Scammell1 and Christopher J. Winrow2 Author information ► Copyright and License information ► The publisher’s final edited version of this […]

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