DeltaFosB-mediated alterations in dopamine signaling are normalized by a palatable high fat diet (2008)

FULL STUDY Biol Psychiatry. 2008 Dec 1;64(11):941-50. Epub 2008 Jul 26. Teegarden SL, Nestler EJ, Bale TL. Source Department of Animal Biology, University of Pennsylvania, Philadelphia, PA 19104-6046, USA. Abstract BACKGROUND: Sensitivity to reward has been implicated as a predisposing factor for behaviors related to drug abuse as well as overeating. However, the underlying mechanisms […]

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(L) Binge eating may lead to addiction like behaviors (2012)

COMMENTS: This is different from the Kenny rat study (2010), in which unlimited access caused obesity and addictio-related brain chnages. However, the kenny rats had access to a variety of high fat high sugar goodies. Either way, it is the binging beyond normal satity that appears to activate deltafosb, which inititaes sensitization. Binge eating may lead to addiction like behaviors […]

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Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis (2009)

COMMENTS: Detailed review of dopamine and the nucleus accumbens in reward and aversion. FULL STUDY William A. Carlezon, Jr.1 and Mark J. Thomas2 Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Neuropharmacology See other articles in PMC that cite the published article. Go to: Abstract The […]

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Overexpression of DeltaFosB is associated with attenuated cocaine induced suppression of saccharin intake in mice. (2009)

FULL STUDY Behav Neurosci. 2009 Apr;123(2):397-407. Freet CS, Steffen C, Nestler EJ, Grigson PS. Source Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. [email protected] Abstract Rodents suppress intake of saccharin when it is paired with a drug of abuse (Goudie, Dickins, & Thornton, 1978; Risinger & Boyce, […]

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Reward Mechanisms in Obesity: New Insights and Future Directions (2011)

 COMMENTS: a review by the top researcher on obesity and food addiction. FULL STUDY Volume 69, Issue 4, 24 February 2011, Pages 664–679 http://dx.doi.org/10.1016/j.neuron.2011.02.016, Review Paul J. Kenny1, , 1 Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA ________________________________________ Food is consumed in order to maintain […]

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(CAUSE) Precursor or Sequela: Pathological Disorders in People with Internet Addiction Disorder (2011)

COMMENTS: A unique study. It follows first year university students to ascertain what percentage develop Internet addiction, and what risk factors may be in play. The unique aspect is that the research subjects had not used the Internet prior to enrolling in college. Hard to believe. After only one year of school, a small percentage were classified […]

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DeltaFosB in the Nucleus Accumbens Regulates Food Reinforced Instrumental Behavior and Motivation (2006)

FULL STUDY The Journal of Neuroscience, 6 September 2006, 26(36): 9196-9204; doi: 10.1523/JNEUROSCI.1124-06.2006 Peter Olausson1, J. David Jentsch2, Natalie Tronson1, Rachel L. Neve3, Eric J. Nestler4, and Jane R. Taylor1 1.Correspondence should be addressed to Jane R. Taylor, Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, Connecticut Mental […]

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