Targeting Gene Regulator in Brain Reward Circuit Eyed as Treatment
Scientists have discovered a mechanism that helps to explain resilience to stress, vulnerability to depression and how antidepressants work. The new findings, in the reward circuit of mouse and human brains, have spurred a high tech dragnet for compounds that boost the action of a key gene regulator there, called deltaFosB.
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Read More… from (L) Delta-FosB Low in Depression, Protects Mice From Stress (2010)
Comments: The rats preferred the intense sweetness of both sugar and saccharine over cocaine. This preference continued even when the dose of cocaine was increased, and when the rats had to work harder to receive their sweet reward. The take away is that the rats preferred a natural reinforcer (sugar) over an addictive drug. Internet […]
Read More… from Intense Sweetness Surpasses Cocaine Reward (2007)
This covers a lot of the basics on dopamine (D2) receptors and addiction.
Volkow May Have Uncovered Answer to Addiction Riddle
Psychiatric News June 4, 2004
Volume 39 Number 11 Page 32
Jim Rosack
http://pn.psychiatryonline.org/content/39/11/32.full
Addictive disorders may be a “shift in the salience meter” in which normal stimuli are no longer recognized as salient, yet the effects of drugs of abuse on the brain’s dopamine system are highly salient, NIDA’s director believes.
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Read More… from (L) Volkow May Have Uncovered Answer to Addiction Riddle (2004)
One of the main hallmarks of an addiction process involves changes in the number of dopamine receptors and types on key nerve cells in the brain. To hear the message, dopamine attaches to receptors on cells. With addiction, some types of receptors decrease, while other types increase. We focus on dopamine receptors, as reduced dopamine […]
Read More… from Dopamine Receptors
I found this material during the summer of 2010 after googling on “orgasm addiction” I think it was. I don’t know exactly what made me google that, but man am I glad I did. An article on this site explained various things: the connection between the dopamine released when the reward center gets stimulated, the […]
Read More… from Five-month plateau
It took me multiple attempts (and I learned from each attempt) but I have now been masturbation and porn free for six months.
The first step (I know this is cliché) is recognizing you have a problem- knowing that your chronic masturbation to porn has adversely affected your life and relationships. I could write a book on how much better my life is now.
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Read More… from 6 months – ED: It is nice to actually get aroused by little things
Give someone a neurotransmitter and they’ll feel good for an hour; teach someone to grow more receptors and they’ll feel good all the time.–Todd Becker
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Read More… from Rebooting Accounts: Page 1
A recovering user found this technique helpful:
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Read More… from The Fast Phobia Cure
Whether you’re trying to overcome an addiction, find a partner, make friends, or just improve your social skills, one of the best things you can do is find local groups of friendly people to hang out with. What do you like to do? Biking, hiking, singing, bird-watching, running? Look around for a local club. Below […]
Read More… from Finding Friendly Groups