Dopamine Regulates Approach-Avoidance in Human Sensation-Seeking (2015)

Int J Neuropsychopharmacol. 2015 Apr 9. pii: pyv041. doi: 10.1093/ijnp/pyv041. Norbury A1, Kurth-Nelson Z2, Winston JS2, Roiser JP2, Husain M2. Abstract Background: Sensation-seeking is a trait that constitutes an important vulnerability factor for a variety of psychopathologies with high social cost. However, little is understood either about the mechanisms underlying motivation for intense sensory experiences […]

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PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens (2015)

PLoS One. 2015 May 11;10(5):e0126710. doi: 10.1371/journal.pone.0126710. eCollection 2015. Ohnishi YH1, Ohnishi YN2, Nakamura T3, Ohno M4, Kennedy PJ5, Yasuyuki O6, Nishi A7, Neve R8, Tsuzuki T4, Nestler EJ5. Abstract ΔFosB is a stable transcription factor which accumulates in the nucleus accumbens (NAc), a key part of the brain’s reward circuitry, in response to chronic […]

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In vivo evidence of neurophysiological maturation of the human adolescent striatum (2015)

Dev Cogn Neurosci. 2015 Apr;12:74-85. doi: 10.1016/j.dcn.2014.12.003. Epub 2014 Dec 30. Larsen B1, Luna B2. Author information 1Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA. Electronic address: [email protected]. 2Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for the Neural […]

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Age 23 – Unemployed, single, depressed, habitual fapper => NoFap N’ Stuff => Job, ladies, grad school, willpower, etc.

DAY 1 I was unemployed out of college, living with my parents, single, and had a porn problem that was destroying my life. Brain fog made intelligible thought near impossible, and anxiety made social contact a terrifying obligation. WEEK 1 Re-started working out (This one’s proven. Boosts confidence, gives you a sense of accomplishment, it’s […]

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Effective connectivity of a reward network in obese women (2009)

Brain Res Bull. 2009 Aug 14;79(6):388-95. doi: 10.1016/j.brainresbull.2009.05.016. Stoeckel LE1, Kim J, Weller RE, Cox JE, Cook EW 3rd, Horwitz B. Abstract Exaggerated reactivity to food cues in obese women appears to be mediated in part by a hyperactive reward system that includes the nucleus accumbens, amygdala, and orbitofrontal cortex. The present study used functional […]

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Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression (2012)

Addict Biol. 2012 Jan; 17(1): 95–107. doi:  10.1111/j.1369-1600.2010.00294.x PMCID: PMC3298643 Karolina P Skibicka, Caroline Hansson, Emil Egecioglu, and Suzanne L Dickson Author information ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract The decision to eat is strongly influenced by non-homeostatic factors such as food […]

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The role of ghrelin in reward-based eating (2012)

Biol Psychiatry. 2012 Sep 1; 72(5): 347–353. Published online 2012 Mar 28. doi:  10.1016/j.biopsych.2012.02.016 PMCID: PMC3388148 NIHMSID: NIHMS360457 Mario Perelló, Ph.D.1 and Jeffrey M. Zigman, M.D., Ph.D.2,3 Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Biol Psychiatry See other articles in PMC that cite […]

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Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin’s effect on food reward but not food intake (2013)

Neuropharmacology. 2013 Oct;73:274-83. doi: 10.1016/j.neuropharm.2013.06.004. Epub 2013 Jun 14. Skibicka KP1, Shirazi RH, Rabasa-Papio C, Alvarez-Crespo M, Neuber C, Vogel H, Dickson SL. Highlights Intra-VTA ghrelin engages accumbal D1 and D2 receptors Food deprivation elevates food reward behavior via accumbal D1 and D2 receptors Food intake is unaffected by accumbal D1 and D2 manipulations. Food […]

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