Psychoneuroendocrinology. 2015 Nov; 61: 53. doi: 10.1016 / j.psyneuen.2015.07.534. Epub 2015 Aug 8.
Chatzittofis A1, Arver S1, Öberg K1, Hallberg J1, Nordström P1, Jokinen J.
Muchidimbu
- Varume vane chirwere che hypersexual vakanga vane huwandu hwakanyanya hweDST kwete kuderedza kudarika.
- Varume vane hypersexual disorder vakange vakanyanya kudarika DST-ACTH mazinga vachienzaniswa nemitemo.
ngovepo
Hypersexual disorder inobatanidza pathophysiological zvimwe zvakadai sokurambidza zvepabonde chido chekuita zvepabonde, zvekuita zvepabonde, kusagadzikana uye kusagadzikana kwakataurwa sechirwere che DSM-5. Zvisinei, zvishomanana zvinozivikanwa pamusoro peeurobiology shure kwechirwere ichi. A dysregulation of the hypothalamic pituitary adrenal (HPA) axis yakaratidzwa mune zvinetso zvepfungwa asi haina kuongororwa muhutano hwe hypersexual. Chinangwa chechidzidzo ichi chaiva chekutsvaga basa reHPA axis muhutano hwe hypersexual.
Chidzidzo chacho chinosanganisira varwere vevarume vane 67 vane hypersexual disorder uye 39 vane hutano varume vanozvipira. Basal mangwanani plasma mazinga e-cortisol uye ACTH yakaongororwa uye chirwere chakaderera (0.5 mg) dexamethasone kupedza kuedza kwakaitwa ne cortisol uye ACTH yakaitwa post dexamethasone administration. Nzvimbo isina kuderedza yakatsanangurwa neDST-cortisol maitiro ≥138 nmol / l. Chirwere chekuita zvepabonde (SCS), Hypersexual disorder chirongwa chezvino chekuongorora (HD: CAS), Montgomery-Åsberg Kuwedzeresa Scale-self rating (MADRS-S) uye Childhood trauma questionnaire (CTQ), yakashandiswa pakuongorora hutano hwehupombwe, kushungurudzika kwakanyanya uye upenyu hwepakutanga.
Varwere vane chirwere che hypersexual vakanyanya zvikuru DST non-suppressors uye vakanga vakanyanya kudarika DST-ACTH mazinga zvichienzaniswa nevanozvipira vane utano. Vachiremba vanonyanya kukosha kwehutano hwemwana uye zviratidzo zvekuora mwoyo zvichifananidzwa nevanozvipira vane utano. CTQ zvikwata zvakaratidza kuwirirana kusina kunaka neDST-ACTH apo SCS neHDH: Zvikoro zveCAS zvakaratidza kusagadzikana kusina kunaka ne cortisol yekutanga kune varwere. Kuongororwa kwehutano hwe hypersexual kwakabatanidzwa zvikuru DST kwete kusaderedza uye yakakwirira plasma DST-ACTH kunyange kana yakagadzirirwa kushungurudzika kwevana.
Zvigumisiro zvinoratidza HPA axis dysregulation mune varwere varume vane hypersexual disorder.
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