COMMENTS: Kunyange pepa iri richingori pfupi pfupi, rine zvishoma zvakakosha zvekutarisa pane kusimuka kwesainzi. Semuenzaniso, inotaura kuti zvese zviri zviviri Prause et al., 2015 uye Kuhn & Gallinat, 2014 rondedzera kufanana kwakafanana: zvinonyadzisira zvinoshandiswa zvinobatanidza nepamusoro pekugara kune zvinonyadzisira. Zvese zvidzidzo zvakataurwa dzikisa brain in activation inopindura kutsvaira pfupi kuzvidhori zvevanilla porn. Muchidimbu chinotevera "Chinyorwa chekupedzisira-chingave chinogona" chinoreva kuwanikwa kweEEG Prause et al.:
"Mukupesana ne, zvidzidzo kune vanhu vane hutano zvinoratidzira basa rekusimudzira tsika yekushandisa zvakanyanya zvinonyadzisira. Muvarume vane hutano, nguva yakawanda yakapedza kutarisa zvinonyadzisira zvakasanganiswa nechezasi kuruboshwe putaminal basa kune zvinonyadzisira mifananidzo (Kühn naGallinat, 2014). Pasi pfupi kusvika kune chimwe chinhu chingaita basa kumifananidzo yezvinonyadzisira yaionekwa muzvidzidzo zvine chinetso chekushandisa zvinonyadzisira. ”
Sei izvi zvichikosha? Mutungamiri anotungamira Nicole Prause akataura kuti iye ega EEG kudzidza debunked "kupindwa muropa nezvinonyadzisira". Iyi ndiyo yechipiri pepanhau-rakaongororwa pepa rekuramba kududzirwa kwaPrause. Heino yekutanga pepa.
Tarira - Akawanda mamwe mapepa akaongororwa nevezera rako anobvumirana izvozvo Prause et al., 2015 inotsigira iyo inodhakwa modhi modhi: Peer-reviewed reviews of Prause et al., 2015
Neuropsychopharmacology 41, 385-386 (January 2016) | maviri: 10.1038 / npp.2015.300
Shane W Kraus 1, 2, Valerie Voon 3, uye Marc N Potenza 2, 4
1 VISN 1 Mental Illness Research Research and Clinical Centers, VA Connecticut Healthcare System, West Haven, CT, USA; 2 Dhipatimendi rePyychiatry, Yale University School of Medicine, New Haven, CT, USA;
3 Dhipatimendi rePsychiatry, Yunivhesiti yeCambridge, Cambridge, UK;
4 Dhipatimendi reNeurobiology, Child Study Center neCASA Columbia, Yale University Chikoro cheMishonga, New Haven, CT, USA
E-mail: [email inodzivirirwa]
Kuita zvepabonde zvepabonde (CSB) kunoratidzirwa nekuchiva, kushushikana, hutano / hutano husina kunaka, uye hutano hwepfungwa. Kuwandisa kweCSB inofungidzirwa pamusoro pe3-6%, ine mukono wevarume. Kunyange zvazvo isina kuiswa mu DSM-5, CSB inogona kuonekwa mu ICD-10 sechirwere chekudzivirira pfungwa. Zvisinei, kukakavadzana kuripo pamusoro pekutsvaga kweCSB (semuenzaniso, sechikonzero chekufungidzira-kusagadzikana, chinokonzerwa nehutano hwehutano hwepabonde, kusvuta, kana kuti pamwe chete nekuenderera mberi kwechiito chekuita zvepabonde).
Uchapupu hwepakutanga hunoratidza kuti dopamine inogona kubatsira ku CSB. Mu chirwere chePacinson (PD), dopamine inoshandiswa kurapwa (Levo-dopa, dopamine agonists) yakabatanidzwa neCSB nemamwe matambudziko ekudzora masimba (Weintraub et al, 2010). Nhamba shomanana yezvidzidzo zviitiko zvinoshandisa naltrexone kutsigirwa kwayo kubudirira pakuderedza kukurudzira uye mafambiro anowanikwa neCSB (Raymond et al, 2010), yakaenderana neaigona kugadziriswa opioidergic ye mesolimbic dopamine basa mukuderedza CSB. Ikozvino, yakakura, yakakwana, inokonzerwa neurochemical uye miedzo yekurapa inodiwa kuti iwedzere kunzwisisa CSB.
Zvinokurudzirwa zvinokurudzira zvinoratidzira kune zvepabonde reactivity. CSB nevarume vasiri CSB vaiva nehupombwe hukuru-cuerelated kushandiswa kweanterior cingulate, ventral striatum, uye amygdala (Voon et al, 2014). Muzvidzidzo zveCSB, kuwirirana kwehutano hwehutano uyu hunoenderana nechishuvo chekuita zvepabonde, zvine chokuita nekuwana zvinodhaka (Voon et al, 2014). CSB varume vanowedzera kuratidza kuwedzerwa kwemaonero ekuona zvinonyadzisira, zvichiita kuti vatange kufungisisa zvinyorwa zvakadai sekunyangadza (Mechelmans et al, 2014). MuCBB nevarwere vasiri CSB PD, kusvibiswa kwezvinonyadzisira kunowedzera kushandiswa mumutambo wekutsvaga, kurongedza uye kurongedza zvinyorwa zvekuita zvepabonde (Politis et al, 2013). Chinhu chiduku-kuparidzira zvidzidzo zvekufungidzirwa zvinosanganisira kusarudzwa kusina kukodzera muCSB nevasiri vemuSBB (Miner et al, 2009).
Kupesana, zvidzidzo mune vanhu vane hutano zvinoratidza chinzvimbo chekuvandudza dzimba nekushandiswa kwakanyanya kwekuona zvinonyadzisira. Mune varume vane hutano, nguva yakawedzerwa inoshandiswa pakuona zvinonyadzisira zvakapindirana nemaitiro epasi kuruboshwe rwemifananidzo yemifananidzo inonyadzisira (Kühn naGallinat, 2014). Kuderera-kwakanonoka kuita kwakaringana chiitiko chezvifananidzo zvinonyadzisira kunoonekwa muzvinyorwa zvine dambudziko rekushandisa zvinonyadzisira. Izvi zvitsva, asi zvakasiyana, hazvisi izvo. Kugara kune chinyorwa chinyorwa maererano nevhidhiyo cues kunogona kuwedzerwa kune vanhu vane utano hwakashandiswa; asi, shanduro dzeCSB dzine ruzivo rwakanyanya / rwechiremera dzinogona kunge dzakasimbiswa cue reactivity.
Kunyange zvazvo zvidzidzo zvenguva yemazuva ano zvichitaura kuti dzimwe nzira dzingave dzakagadzikana neurobiological yeCSB, izvi zvinogadziriswa zvinofanira kuonekwa sekutengesa zvakapiwa nzira dzekukanganisa (semuenzaniso, mashoma mashoma masikisi, zvinyorwa zvitsvene, zvigadziriswe varume chete, zvichingodaro). Nzvimbo dzekutsvakurudza dziripo dziripo dzinomanikidzira kugadziriswa kwechokwadi kana iSBB inonyanya kuonekwa sechinhu chinodhaka kana kwete. Ongororo yakawedzerwa inodiwa kuti inzwisise kuti sei neurobiological zvinhu zvine chokuita nehutano hwakakosha hunoenderana nemigumisiro yehutachiwana yeCBB. Kuenzanisa CSB se "tsika inodhaka" kunobatsira zvikuru pamutemo, kudzivirira nekurapa; zvisinei, panguva ino, tsvakurudzo iri mumwana wayo. Zvimwe zvakafananidzwa pakati peSCB uye zvinodhaka zvinodhaka, kupindira kunobudirira kune zvinodhaka zvinogona kubata chivimbiso cheCSB, nokudaro kunopa ruzivo pamusoro pekutsvaga tsvakurudzo kunobvunzurudza izvi zvichida zvakananga.
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- Mechelmans DJ, Irvine M, Banca P, Porter L, Mitchell S, Mole TB uye al (2014). Kuwedzera kushamwaridzana kune zvepabonde zvinotsanangurwa zvevanhu pabonde vane uye vasina kuomerera kuita zvepabonde. PloS One 9: e105476.
- Miner MH, Raymond N, Mueller BA, Lloyd M, Lim KO (2009). Kutanga kuongorora kwemaitiro asina kufungira uye euroanatomical ekumanikidzira kuita zvepabonde. Psychiatry Res 174: 146-151.
- Politis M, Loane C, Wu K, O'Sullivan SS, Woodhead Z, Kiferle L et al (2013). Neural response kune zvinoratidzirwa zvepabonde mune dopamine-hutano hwehupombwe huri muhutano hwePasinson. Ubongo 136: 400-411.
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- Voon V, Mole TB, Banca P, Porter L, Morris L, Mitchell S et al (2014). Neural correlates zvekuita zvepabonde reactivity kune vanhu vane uye vasina kunyengedza kuita zvepabonde. PloS One 9: e102419.
- Weintraub D, Koester J, Potenza MN, Siderowf AD, Stacy M, Voon V et al (2010). Kukanganisa kumira kwezvirwere muPasinsinon: chirwere chepakati chechikamu chevarwere ve3090. Arch Neurol 67: 589-595. Neuropsychopharmacology Reviews (2016) 41, 385-386; doi: 10.1038 / npp.2015.300
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