COMMENT: Uropi hutsva scan scan kuenzanisa chena nyaya ye porn / dzepabonde vanopindwa muropa (CSBD) kumatongero akataurwa misiyano yakakosha pakati peanodzora uye CSB zvidzidzo:
Ichi ndicho chimwe chezvidzidzo zvekutanga zveDTI zvichitarisa musiyano uripo pakati pevarwere neCompulsive Sexual Behaviors Disorder uye kutonga kwakanaka. Kuongorora kwedu kwakaburitsa kuderedzwa kweFA mumatunhu matanhatu ehuropi mune CSBD zvidzidzo, zvichienzaniswa necontrol. Maturakiti ekusiyanisa akawanikwa mucerebellum (panogona kunge paine zvikamu zveturakiti imwe mucerebellum), iyo chikamu chakadzoserwa chemukati kapsule, iyo yepamusoro corona radiata uye yepakati kana yekupedzisira occipital gyrus chena nyaya.
Zvigumisiro zvekudzidza kwedu zvinoratidza kuti CSBD inogovera maitiro akafanana ezvakaipa pamwe neOCD uye kupindwa muropa.
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- 1 Institute of Psychology, Polish Academy of Sciences, Warsaw, Poland
- 2 Rorusununguko Psychology, SWPS University of Social Sciences uye Humanities, Warsaw, Poland
- 3 Laboratory yeBurin Kufananidza, Neurobiology Center, Nencki Institute of Ongororo Biology, Polish Academy yeSainzi, Warsaw, Poland
- 4 Biomedical Imaging Research Institute, Misidhari-Sinai Medical Center, Los Angeles, USA
- 5 Swartz Center yeComputational Neuroscience, Institute for Neural Computations, Yunivhesiti yeCalifornia San Diego, San Diego, USA
ngovepo
Mhemberero uye zvinangwa
Kunyangwe hazvo iyo Inomanikidza Zvepabonde Behaviour Disorder (CSBD) yakawedzerwa kune iyo ICD-11 pasi pechisimba chekudzora chikamu mu2019, ayo neural nzira dzichiri kupokana. Vatsvakurudzi vakaona kufanana kwaro kune kupindwa muropa uye neOsensive-Compulsive Disorder (OCD). Chinangwa chekudzidza kwedu kwaive kugadzirisa uyu mubvunzo nekutsvaga maitiro eatomical uropi husina kujairika pakati pevarwere veCSBD.
nzira
Kuongorora makumi matatu neshanu paDambudziko Rekufungidzira Tensor (DTI) isu takaratidza kukanganisika kukuru kwakanangana nezvinodhakwa uye OCD. Kupfuura isu takaunganidza DTI dhata kubva kune makumi matatu nevarume vanoita zvepabonde vanowanikwa vane CSBD uye makumi matatu nematatu akaenzana masimba ane hutano. Iyi mhedzisiro yakazoenzanisirwa neyekupindwa muropa uye OCD maitiro.
Results
Zvichienzaniswa nekudzora, vanhu veCSBD vakaratidza kukosha kweanisotropy (FA) kudzikira kwepamusoro corona radiata turakiti, yemukati kapuleti turakiti, cerebellar maturakiti uye occipital gyrus chena nyaya. Sezvineiwo, matunhu ese aya akaonekwawo muzvidzidzo zvakapfuura sekugovaniswa DTI kuwirirana mune ese OCD uye kupindwa muropa.
Kukurukurirana uye kugadzirisa
Zvigumisiro zvekudzidza kwedu zvinoratidza kuti CSBD inogovera maitiro akafanana ezvakaipa pamwe neOCD uye kupindwa muropa. Seimwe yeiyo yekutanga DTI kudzidza kuenzanisa mamiriro ehuropi misiyano pakati peCSBD, kupindwa muropa uye OCD, kunyangwe ichiratidza zvinhu zvitsva zveCSBD, haina kukwana kuona kana CSBD yakafanana neakawanda kupindwa muropa kana OCD. Kuenderera mberi nekutsvagisa, kunyanya kuenzanisa chaiko vanhu vane matambudziko ese matatu kunogona kupa mhedzisiro yakajeka.
ziviso
Iyo Inomanikidzira Zvepabonde Zvinokanganisa Dambudziko (CSBD) yakaunzwa neWorld Health Organisation (WHO) muchikamu chegumi nerimwe cheInternational Classification of Diseases (ICD-11) chirwere chepfungwa chinoratidzirwa nekukundikana kuramba kuramba kurudziro yekuita zvepabonde. Pakutanga, zviitiko izvi zvinopa mubairo kumurwere, asi mushure mechinguva zvinova zvinokuvadza uye zvisina basa, zvichikonzera huwandu hwepamusoro hwekunetseka. Kuti usangane neCBBD yekuongorora nzira, murwere anofanira kuratidza zviratidzo zvataurwa pamusoro kweinenge mwedzi mitanhatu, uye kuongororwa hakugone kuitwa kana pasina kushushikana kwakanyanya muhupenyu hwehupenyu kuchitaurwa kana kana kutambudzika kuri kwakanangana nekutonga kwetsika nekusatendera zvebonde, nekuti semuenzaniso, zvichibva pane zvechitendero / zvetsika zvitendero (Kraus et al., 2018; WHO, 2019). Maitiro eCSBD akarongwa neWHO mukukura kukuru aive akavakirwa pamatanho eiyo hypersexual kusagadzikana (HD) yakarongedzwa na Kafka (2010) yekutarisa muchikamu chekusangana pabonde cheDSM-V. Saizvozvowo neHD, CSBD yakafungidzirwa sechisimba chisingaenzaniswi chepabonde chishuwo nechishuvo chekushushikana, ichiita senge kupindwa muropa, zvisinei neiyo HD, CSBD iyo yekurasa kuraswa kwekushushikana uye mutemo wemanzwiro (akafanana neOCD) (kuti uwane hurukuro yakadzama ona: Gola et al., 2020).
WHO yakaronga CSBD (muICD-11) sechisimba chekudzora kusagadzikana, asi chimiro chekumanikidza chinosanganisirwa muzita rechirwere. Nehurombo, iyo yekumanikidza yekudzora kusagadzikana chikamu chakanyanyisa uye miganhu yayo haigone kunyatsotsanangurwa, izvo zvinoita kuti CSBD iratidzwe chidzidzo chekupokana nharo, yakanangana nemubvunzo wekuti kana zviratidzo zveCSBD zviri zvekumanikidza kana zvekumanikidza mune yavo chimiro, kana CSBD inofanira zvirinani kutorwa senge kuratidzwa kwehunhu hunodhaka (semuenzaniso, Bőthe et al., 2019; Gola et al., 2017; Griffiths, 2016; Kraus, Voon, & Potenza, 2016; Kühn & Gallinat, 2016; Potenza, Gola, Voon, Kor, & Kraus, 2017; Muduku, 2008) kana imwewo mhando yechirwere chepfungwa. Kana vachipokana nezvekufanana kwadzo kupindwa muropa, vaongorori vanowanzo taura nzira dzekugunzva uye kupanga zvebonde (Kwayedza, 2018; Gola et al., 2017; Klucken, Wehrum-Osinsky, Schweckendiek, Kruse, & Stark, 2016; Kowalewska et al., 2018; Voon et al., 2014), Kushivirira kuri kukura uye kuwedzera kwezviratidzo, zvinowanzoitika pakuvimba nezvinhu (Reid et al., 2012; Wordecha et al., 2018), uye iyo yekusiya chirwere (Garcia & Thibaut, 2010). Kune rimwe divi, CSBD zvakare inofananidzwa neObsessive-Compulsive Disorder (OCD), sezvo ichigona kuratidza kutenderera kwemafungiro asina kunaka, pfungwa dzakaperekedzwa pamwe nekumanikidzwa, kureva tsika, kudzokorora maitiro anoderedza kusagadzikana kunokonzerwa nepfungwa dzakapfurikidza, kuita kudzivirira kana kuderedza kushushikana kana kushushikana (Mudhikoni & Abramowitz, 2005; Fineberg et al. 2014). Hunhu hwepabonde hunogona kutora chinhanho mukugadzirisa marongero emitemo yekunzwa (Lew-Starowicz, Lewczuk, Nowakowska, Kraus, & Gola, 2020) Maererano ne Coleman uye vamwe (2003), Varwere veCSBD vanowana kudzokorora pfungwa dzebonde dzinokonzeresa kusagadzikana (kubatikana), uye kuita tsika dzekumanikidza dzepabonde kudzikisa kusagadzikana uku (Coleman, Raymond, & McBean, 2003). Nenzira iyi, maitiro epabonde anogona kunzwisiswa sekuratidzwa kwekumanikidza (Mick & Hollander, 2006) uye hunhu hwepabonde hunotora chinhanho chemanzwiro ekuronga zano (Kafka, 2010; Mucheri, Dickenson, & Coleman, 2019; Reid & Kafka, 2014). Parizvino iri basa rekugadzirisa inyaya yekukurukurwa mumamiriro eCSBD, sezvo zvaive zvino zvabatanidzwa mumatanho eWHO (Gola et al., 2020).
Kune humwe huri kukura hwehuchapupu hunotaura mukufarira kufanana kweurourobiological pakati peCSBD nezvinodhakwa, semuenzaniso, zvine chekuita nezvehukama-zvine chekuita nezve reactivity yemubairo system (yekuwongorora ona. Kwayedza, 2018 or Kowalewska et al., 2018). Pakati pezvakanyanya kufadza mhedzisiro ndeiyi: yakawedzera ventral striatal reactivity yemifananidzo yakasarudzika yemifananidzo (ichienzaniswa neisina-kusarudzika mifananidzo) inowirirana zvine mhedzisiro muInternet Addiction Test Modified yeCybersex (Brand, Snagowski, Laier, & Maderwald, 2016).Seok & Sohn, 2015). CSBD vanhu vakaratidzawo kuwedzera kwekurohwa reactivity (zvichienzaniswa nemaitiro) emavhidhiyo anoburitsa zvepabonde (Voon et al., 2014) kana erotic asi kwete emari cues (Gola et al., 2017) uye kudzikira kwekubatana kweanoshanda pakati peiyo ventral striatum uye nekamberi cortex (Klucken et al., 2016), pamwe nekukosha kwakashata kusawirirana pakati pekuoma kwezviratidzo zveCSBD nekubatana kunoshanda pakati peiyo kuruboshwe yepamusoro tempiro gyrus uye kurudyi caudate nucleus (Seok & Sohn, 2018). Nezve chimiro chehuropi mhedzisiro inoenderana neCSBD, Kühn naGallinat (2014) vakawana hukama hwakapesana pakati peakarurama caudate volumetry uye kuwanda kwekuona zvinonyadzisira kushandiswa pakati pevasiri-kiriniki vanoshandisa zvinonyadzisira. Chazvino kudzidza kubva kuboka redu (Draps et al., 2020) yakaratidza kuti vanhu vane CSBD, kupindwa muropa nedoro uye kubhejera kusagadzikana vanogovana diki grey nyaya vhoriyamu kuruboshwe pamberi pechipfu (kunyanya mu orbitofrontal cortex) kana ichienzaniswa nezvidzidzo zvine hutano. Iyi data yataurwa pamusoro inotsigira iyo fungidziro pane fanano pakati peCBBD nezvinodhakwa. Nehurombo, hapana zviripo neurobiological zvidzidzo zvekuenzanisa CSBD neOCD.
Imwe nzira yekudzidza mikana yakafanana pakati peCSBD uye kupindwa muropa kana OCD ndeyekutarisa kuuropi chena nyaya microstructure. Kusiyanisa Tensor Kufungidzira (DTI) ndeye yemagineti resonance imaging nzira inoenderana neiyo micostructural maturusi zvivakwa, ichibvumidza iyo yemhando yekuyera yechena nyaya maturakiti (Basser & Jones, 2002; Guevara, Guevara, Román, & Mangin, 2020; Le Bihan, 2003; Le Bihan et al., 2001). Kune akawanda matekiniki eDTI, semuenzaniso iyo Tract-Based Spatial Statistics (TBSSs) nzira inoshandiswa zvakanyanya kuona chena nyaya dzakashata muvanhu (Smith et al., 2006), iyo inotarisa zvakanyanya pamisiyano yezvikamu zveanisotropy (FA). Mukuongorora kweTBSS iyo nonlinear yekunyoresa algorithm inoshandiswa kuratidza yega data pane zvinoreva tarakiti inomiririra, inonzi inoreva FA skeleton. Isu takawana makumi matatu neshanu zvinyorwa paOCD (39) uye kupindwa muropa (31) tichishandisa TBSS. Mune izvi zvidzidzo, vanyori vakaratidza misiyano yeFA pakati pevane 8 vane hutano hwakanaka uye 1,050 vakura varwere vanoonekwa kuti vane OCD kana kupindwa muropa nedambudziko. Iwo madiki madiki evatori vechikamu aive akateedzana: 1,188 mune kupindwa muropa (Chumin et al., 2019) uye vasere muboka reOCD (Cannistraro et al., 2007). Zvidzidzo makumi maviri nesere zvakaratidza zviitiko zvakakosha ne P <0.05 mushure mekugadziriswa kwekufananidza kwakawanda uye 6 isina kurongeka P <0.001, ine saizi remasumbu makumi maviri kana anopfuura ma voxels. Kusiyana kwenzvimbo kwakanyanya kudanidzirwa muOCD, nemhedzisiro inoratidza kupesana kukuru kweFA mumaturakiti akati wandei senge corpus callosum, cingulum bundle, forceps madiki uye corona radiata. Mhedzisiro yacho yaive sparser muzvidhakwa, iine mashoma maseru achiparadzanisa pakati pemapoka evarwere neanodzora. Sezvineiwo, mapfumbamwe matunhu (kureva. Epamusoro corona radiata, yemukati capsule, cerebellum, occipital uye kumberi chena nyaya, yepamusoro fasciculus, posterior thalamic radiata, corpus callosum uye thalamus) zvakaratidzwa seDTI inoenderana zvese, zveOCD nezvinodhaka (ona Fig. 1).
Mhedzisiro yekuongorora kwemabhuku. Fractional anisotropy (FA) kuderedzwa kwakanangana neAddiction (bhuruu), FA kudzikisira yakanangana neOCD (girini), uye matunhu anosiyanisa vese Kupindwa muropa uye OCD varwere kubva kuhutano hwakanaka (yero)
Citation: Zvinyorwa zveZviito zveKutadza JBA 2021; 10.1556/2006.2021.00002
Muchidzidzo chedu isu takanangana ne (1) kuona zvakashata zveFA zvakanangana neOCD nezvinodhaka kuburikidza nekuongororwa kwemabhuku, (2) kuunganidza DTI dhata kubva kuvarwere veCSBD nekutonga kune hutano (kushandisa TBSS nzira yekuona mutsauko muFA), uye (3) enzanisa mhedzisiro yedu nezvakambotaurwa zvakawanikwa paOCD uye kupindwa muropa, kuona kufanana kana / uye misiyano pakati peOCD, zvinodhaka uye CSBD.
nzira
Iyo DTI kudzidza
Zvidzidzo nekutora
Muenzaniso wacho waive ne67 varume vanoita zvepabonde vakapatsanurwa mumapoka maviri: 36 varwere veCSBD uye makumi matatu nematatu ane hutano (HCs) Zvidzidzo zvakafananidzwa nezera uye mari (ona ruzivo rwehuwandu mu Tafura 1). CSBD zvidzidzo zvakanyoreswa pakati pevarume vachitsvaga kurapwa mumakiriniki muWarsaw, Poland. Vakabvunzurudzwa nevarapi vezvepfungwa uye vezvepfungwa kuti vasimbise kuongororwa maererano nemaitiro aKafka HD (Kafka, 2010). Dzese dzakasangana mana kubva mashanu mashanu A maitiro, uye zvakare akazadzikisa B uye C maitiro (Kafka, 2014). HC yakanyoreswa kuburikidza nezviziviso zvepamhepo, uye haina kuratidza zviratidzo zvepfungwa uye vaive noutano hwakanaka. Kuregererwa kwemaitiro emapoka ese ari maviri yaive nhoroondo yezvimwe zvinetso zvepfungwa, zvetsinga kana zvekurapa zvakakomba nyaya, uye contraindication yemagineti resonance imaging (MRI) maitiro. Vese vatori vechikamu vakapedza mabvunzo ekuyera CSBD zviratidzo: Zvepabonde Kupindwa muropa Kuongorora Bvunzo (ChiPolish vhezheni: SAST-PL-M: Gola et al., 2016) uye iyo Pfupi Yezvinonyadzisira Screen (Kraus et al., 2020). Munguva yekushandira vatori vechikamu vakaongororwawo zvekuita zvepabonde, nhoroondo yekunwa doro zvisina kufanira uye matambudziko ekubhejera. Maitiro ekubatanidzwa emapoka ese aive: chete kana kunyanya kuita zvepabonde paKinsey Scale (chiPolish adaptation: Wierzba et al., 2015); zvibodzwa <10 paAlcohol Use Disorder Identification Test (Babor, de la Fuente, Saunders, & Grant, 1989); uye zvibodzwa <4 paSouth Oaks Kubhejera Screen (Stinchfield, 2002). Vadzidzi vanokodzera vakakokwa kuti vashanyire Laboratory yeBrain Imaging yeNencki Institute, PAS (Warsaw, Poland) yekutora data.
Tafura 1.Vatori vechikamu vane hunhu
| CSBD (kureva [sd]); n = 36 | HC (kureva [sd]); n = 31 | P-value | |
| Zera mumakore | [31.11] | [31.84] | NS |
| Zvepabonde kupindwa muropa kuongororwa - kuyedzwa | [11.63] | [2.67] | P <0.001 |
| Muchidimbu zvinonyadzisira | [6] | [1.73] | P <0.001 |
| Maodzanyemba emaoki kubhejera skrini | [0.33] | 0 | NS |
| Doro shandisa kusagadzikana kuzivikanwa bvunzo | [7.5] | [4] | P = 0.013 |
| Inotarisa-Inomanikidza Inventory - yakagadziriswa | [17.18] | [13.1] | NS |
| Yemari Sarudzo Mubvunzo - zvachose K ukoshi | [0.0249] | [0.0307] | NS |
DTI Kuongorora protocol
Mifananidzo yese yeDTI yakaunganidzwa pane 3-Tesla MRI scanner (Siemens Magnetom Trio TIM, Erlangen, Germany) yakashongedzwa ne12-chiteshi yakamisikidzwa yakarongedzwa musoro coil. Iyo Spin-echo diffusion inorema echo planar imaging (DW_EPI) kuteedzana kwakaitwa pamwe nematanho anotevera: TR = 8,300 ms; TE = 87 ms; GRAPPA; flip angle 90 °, voxel size = 2 × 2 × 2 mm3, 64 gradient directions ne b-kukosha kwe1,000 s / mm2, pamwe nemifananidzo miviri isina dhizaidhi yakashandiswa (b-kukosha = 0). Iyo DW_EPI nhevedzano yakadzokororwa muchikamu chakatarisana encoding madhiri anterior-posterior (AP) uye neashure-anterior (PA).
DTI kugadzirisa mufananidzo
Mifananidzo yeDTI yakagadziriswa neiyo FSL (3.2.0) package kubva kuFMRIB Software Library (FSL, www.fmrib.ox.ac.uk/fsl) (Smith et al., 2004). Kutanga, FSL's fslroi raira raishandiswa kuburitsa iyo b0 mifananidzo. Padanho rinotevera, data rakagadziridzwa pachishandiswa zvigadziriso zvekufungidzira (topup) basa pahwaro hwemaviri b0 mifananidzo yakawanikwa mune yakatarisana chikamu encoding mafambiro. Iko kuwanikwa kweAP uye PA madhairekitori kwakabatanidzwa kuita imwechete-yemhando faira. Uchishandisa iyo FSL Brain Extraction Chishandiso (bheji), ese asiri europi ma voxels uye ese mavoxels ane shoma shoma chikamu mupiro vakasiyiwa kubva kune hukuru mufananidzo. Yakajairika inofamba uye eddy-yazvino kururamisa yakaitwa neFSL's eddy chishandiso. Kuti ikwane modhiyo yekuparadzanisa tensor pane yega voxel, FA mifananidzo yakaverengerwa ne dtifit.
Iyoipiipi yeTBSS yaive nematanho anotevera akaenzana (Smith et al., 2006): (1) DTI-yakatorwa mifananidzo yeFA yaive yakanyoreswa kune template. Iyo FMRIB58_FA yakajairwa-nzvimbo mufananidzo waishandiswa sechinangwa muTBSS. (2) Tevere, iyo isina mutsetse inoshandura yakaverengerwa mudanho rapfuura yakashandiswa kune zvese zvidzidzo kuunza dhata yavo mu1x1x1 MNI152 yakajairwa nzvimbo. (3) Zvinoreva FA uye mafupa kubva kuzvidzidzo zviri muchidzidzo zvakaverengerwa. (4) Kuvharidzira zvinorehwa FA skeleton mufananidzo padanho re0.2 yakashandiswa kuzivisa makuru machena nyaya nzira.
Statistical Ongororo yeiyo DTI data
YeTBSS, voxelwise general linear modelling ongororo yakaitwa pane yakazara data rehuropi, uchishandisa chiuru mvumo mvumo yekuwana iyo FA skeleton voxels ine musiyano wakakura pakati peanodzora ane hutano neboka reCSBD. Iyo maviri-mapoka musiyano modhi yakagadziriswa yezera (zvinoreva pakati peboka) yakashandiswa. Hapana mavoxel akapona iyo FDR (nhema yekuwana mwero) kururamisa kwekuenzanisa kwakawanda. Kuongorora kusina kukodzera kwakaitwawo, nechikwereti cheP chinotanga kubva pa1,000 kusvika ku0.05 uye hukuru hukuru hwemasumbu> 0.01 voxels. Kuverengera kwenhema kuwanikwa mwero (FDR) kururamisa kwakaitwa uchishandisa Matlab script kubva Genovese, Lazar, & Nichols, (2002). Nzvimbo dzemusiyano wakakomba pasi pechikumbaridzo chisina kukodzera che P <0.02 ine 50-voxel mwero inoratidzwa pazasi. Iyo anatomical matunhu ari mumasaga anoratidza akakosha eboka misiyano mune tensor yakatorwa paramende (zvinoreva FA) yakabva yazivikanwa ndokunyorerwa maererano nezvimiro zvakatsanangurwa mune chena nyaya (WM) Atlas (Oishi, Faria, Van Zijl, & Mori, 2010). Idzi anatomical matunhu aishandiswa kumhanyisa kuwirirana kuongorora nezviratidzo zvakayerwa neKupindwa muropa Kwepabonde Screening TestGola et al., 2016) uye iyo Pfupi Yezvinonyadzisira Screen (Kraus et al., 2020) muboka reCSBD.
Ethics
Chibvumirano chevatori vechikamu chakawanikwa pakutanga kwekudzidza. Kuona kusazivikanwa, maitiro maviri-mapofu akashandiswa, zvekuti nhengo dzeboka rekutsvagisa rinotarisira kuwana DTI data vaive vasina mukana wekutora marekodhi uye vaisaziva kana paine chero munhu akapiwa aive muCSBD kana HC boka. Maitiro ese akaitwa zvinoenderana neChiziviso cheHelsinki. Chidzidzo ichi chakatenderwa nekanzuru yekanzuru yemitemo yeInstitute of Psychology, PAS.
Results
Vatori vechikamu
Tafura 1 ine ruzivo nezve vanhu makumi matatu nevatanhatu vane CSBD uye makumi matatu nematatu akawiriranwa, ane data reDTI rakaongororwa muchidzidzo chino. Paive pasina pakati-peboka misiyano mune anoreva zera. CSBD varwere vakawana zvikwiriso zvakanyanya pachikero kuyera CSBD kuomarara (SAST-R: t = 9.738 P <0.001; BPS: t = 6.623 P<0.001). Kune vese vatori vechikamu, zviyero zvekuyera kupindwa muropa nezviratidzo zvaive pazasi pechikumbaridzo (AUDIT: t = 3.012 P = 0.013, SOGS: t = 0.81 P <0.001). Varwere veCSBD vakakwira zvakanyanya kupfuura kutonga muAlcohol Use Disorder Identification Test (Babor et al., 1989), asi hapana chakapfuura chinwiwa chekushandisa kusagadzikana (16 poindi). Mapoka haana kusiyana paObsessive-Compulsive Inventory-Revised (t = 1.580, P = 0.12; OCI-R, Foa et al., 2002) uye Yemubvunzo Sarudzo Yemibvunzo (t = -0.482, P = 0.632; MCQ, Kirby & Marakovic, 1996kuyera kusagadzikana uye kudzikisira (Marcowski et al., Mukudhinda).
Mhedzisiro yeDTI
Isu takawana rakakura misiyano yeboka mumatanhatu matanhatu eatomical masumbu (mhedzisiro yese haina kugadziriswa, ine chikumbaridzo kukosha kwe P kubva pa0.05 kusvika ku0.01 uye kukura kwesango rakakosha remakumi mashanu ema voxels). Zvinoenderana neiyo White Matter Atlas (Oishi et al., 2010), masumbu aya ane anotevera matunhu: matatu maturakiti mucerebellum, retrolenticular chikamu chemukati capsule turakiti, chikamu chepamusoro checorona radiata turakiti uye chikamu cheiyo occipital gyrus chena nyaya (ruzivo mukati Tafura 2 uye Fig. 2). Pakanga pasina kuwirirana kwakakosha pakati peumwe munhu anoreva FA mumatunhu matanhatu eatomical uye kuomarara kwezviratidzo zveCSBD, sekuyerwa neKuita Zvepabonde Kuwedzeredza Kuongorora Bvunzo (Gola et al., 2016) uye Pfupi Zvinonyadzisira Screen (Kraus et al., 2020). Izvi zvaive zvisingatarisirwi, nekuti, zvinoenderana nemabhuku ehurwere hwepfungwa senge kupindwa muropa uye OCD, kuomarara kwezviratidzo kunowanzoenderana nemisiyano muFA (yekupindwa muropa, ona: Morales, Jones, Harman, Kubata-Boka, & Nagel, 2020; De Santis et al., 2019; uye yeOCD: de Salles Andrade et al., 2019; Fitzgerald, Liu, Reamer, Taylor, & Welsh, 2014; Koch et al., 2012; Saito et al., 2008; Wang et al., 2018; Zhou et al., 2018).
Tafura 2.Mhedzisiro kubva kuDTI kudzidza ichifananidza varwere ve36 CSBD vane 31 vakaenzana kutonga kwakanaka
| indekisi | Saizi yemasumbu | x | y | z | T-stat Kukosha kwepamusoro | P kukosha kwepamusoro | Kubatsira kwehukurua | Tract-zita kubva kuAtlas |
| 1 | 61 | 30 | -45 | -28 | 5.3103 | 0.000027776 | 1.290118 | ch, cerebellar hemisphere |
| 2 | 65 | -17 | -49 | -20 | 5.1651 | 0.000046134 | 1.071367 | ch, cerebellar hemisphere |
| 3 | 88 | 24 | -51 | -20 | 5.0823 | 0.000061393 | 1.015533 | ch, cerebellar hemisphere |
| 4 | 64 | 33 | -29 | 6 | 5.1738 | 0.000044763 | 1.125174 | rlic, retrolenticular chikamu chemukati capsule |
| 5 | 52 | -40 | -62 | 20 | 4.9949 | 0.000082731 | 1.151454 | O2-WM, yepakati kana yekupedzisira occipital gyrus chena nyaya |
| 6 | 71 | -25 | 14 | 28 | 4.1236 | 0.0013267 | 0.829666 | scr, mukuru corona radiata |
Cohen's d saizi yekuita yakaverengerwa seyakasiyana musiyano pakati pemapoka maviri akapatsanurwa neakaunganidzwa mwero kutsauka.
Misiyano muchidimbu anisotropy (FA) pakati pevarwere veCSBD nekutonga. Zvinoreva FA skeleton pane ese masvomhu anoratidzwa mune girini pamusoro peMFRIB58_FA_1mm template. Mhedzisiro yakakwidziridzwa yekuona zvinangwa uchishandisa yakajairwa tbss_fill FSL raira. Masumbu ane yakakwira FA tsika (P <0.02, masumbu masumbu> 50) muboka rekutonga mukuenzanisa nevarwere veCSBD inoratidzwa mune tsvuku. Pakanga pasina mhedzisiro yakakosha yekusiyanisa musiyano (varwere veCSBD> boka rekutonga)
Citation: Zvinyorwa zveZviito zveKutadza JBA 2021; 10.1556/2006.2021.00002
hurukuro
Ichi ndicho chimwe chezvidzidzo zvekutanga zveDTI zvichitarisa musiyano uripo pakati pevarwere neCompulsive Sexual Behaviors Disorder uye kutonga kwakanaka. Kuongorora kwedu kwakaburitsa kuderedzwa kweFA mumatunhu matanhatu ehuropi mune CSBD zvidzidzo, zvichienzaniswa necontrol. Maturakiti ekusiyanisa akawanikwa mucerebellum (panogona kunge paine zvikamu zveturakiti imwe mucerebellum), iyo chikamu chakadzoserwa chemukati kapsule, iyo yepamusoro corona radiata uye yepakati kana yekupedzisira occipital gyrus chena nyaya.
Kuti titarise mhedzisiro iyi mumamiriro akapamhama ehurongwa hwese hwekushushikana uye nekumanikidza kusagadzikana kwepfungwa, kubva kupindwa muropa nekumwe kunyanyisa kuenda kune OCD kune imwe, takaitisa ongororo yakazara yemabhuku paDTI mune ese ari pamusoro ataurwa makiriniki masangano. Zvidzidzo makumi matatu nezvipfumbamwe (zvisere nezvekupindwa muropa uye 31 paOCD) zviripo mumabhuku zvakaratidza kuti, sekureva DTI, pane zvishoma neuronal kusiyanisa muropa kupfuura muOCD. Mune zvinyorwa zveOCD, mhedzisiro uye inowanzo kutaurwa ine chekuita nekudzikiswa kweFA munzvimbo dzakadai seiyo corpus callosum uye cingulum bundle (Benedetti et al., 2013; Bora et al., 2011; Cannistraro et al., 2007; de Salles Andrade et al., 2019; Fan et al., 2016; Gan et al., 2017; Garibotto et al., 2010; Li et al., 2011; Nakamae et al., 2011; Ah et al., 2012; Saito et al., 2008; Spalletta, Piras, Fagioli, Caltagirone, & Piras, 2014; Versace et al., 2019; Yoo et al., 2007; Zhou et al., 2018). Mukupesana, iyo inodhakwa zvinyorwa inotaura nezve posterior corona radiata, yekunze capsule, fornix, insula uye hippocampus senzvimbo dzinosiyanisa varwere nekutonga maererano nerevo FA (Chumin et al., 2019; De Santis et al., 2019; Pandey et al., 2018; Yip et al., 2017; Zou et al., 2017), pamwe nedzimwe nzvimbo dzinowanikwa muOCD, kureva, iyo yepamusoro corona radiata, yemukati capsule, cerebellum, kumberi uye occipital chena nyaya, yepamusoro fasciculus, posterior thalamic radiata, corpus callosum uye thalamus (Benedetti et al., 2013; Cannistraro et al., 2007; Chumin et al., 2019; Fan et al., 2012; Fontenelle et al., 2011; Gan et al., 2017; Hartmann, Vandborg, Rosenberg, Sørensen, & Videbech, 2016; Kim, Jung, Kim, Jang, & Kwon, 2015; Lochner et al., 2012; Pandey et al., 2018; Segobin et al., 2019; Szeszko et al., 2005; Yip et al., 2017; Yoo et al., 2007; Zhong et al., 2019; Zou et al., 2017). Dzimwe nzvimbo dzinowanikwa muOCD sudies dziri munzvimbo yakasvibira mu Maonde. 1 uye 3 (Glahn, Prell, Grosskreutz, Peschel, & Müller-Vahl, 2015; Iye et al., 2018; Li, Ji, Li, Li, & Feng, 2014; Menzies et al., 2008; Nakamae et al., 2008; Segobin et al., 2019).
Yedu DTI dhata inoratidza kuti iyo neural correlates yeCSBD inopindirana nematunhu akambotaurwa mumabhuku senge zvakabatana zvese, kupindwa muropa uye OCD (ona iyo tsvuku nzvimbo mukati Fig. 3). Nekudaro, iyo yazvino kudzidza yakaratidza fanano yakakosha mukugovana FA kuderedzwa pakati peCSBD uye ese OCD uye zvinodhaka. Nehurombo, mhedzisiro iyi hairatidze kuti ndeapi eaya maviri emakiriniki epedyo ari padyo neCSBD maererano neDTI correlates.
Kupindirana mhedzisiro kubva kuongororo yemabhuku pane fractional anisotropy (FA) muAddiction uye OCD, uye mhedzisiro yeedu DTI kudzidza kune varwere veCSBD. Kuderedzwa kweFA kwakanangana neAddiction (bhuruu), FA kudzikisira yakanangana neOCD (girini), matunhu anosiyanisa vese Kupindwa muropa uye OCD varwere kubva kuhutano hwakanaka (yero), nenzvimbo dzinosiyanisa varwere veCSBD kubva kuhutano hwakanaka (tsvuku): 3 maturakiti mucerebellum, retrolenticular chikamu chemukati capsule turakiti, chikamu chepamusoro chekorona radiata turakiti uye chikamu cheiyo occipital gyrus chena nyaya.
Citation: Zvinyorwa zveZviito zveKutadza JBA 2021; 10.1556/2006.2021.00002
Nokuremara
Nepo chidzidzo chezvino chichiunza dhata nyowani pane chena nyaya misiyano muhuropi diffusivity muCSBD, mhedzisiro yacho ine zvimwe zvisingakwanisike. Kukosha kukuru kunowanzoitika kune urwu rudzi rwekudyidzana kwekudzidza, uye kunetsekana nenyaya yekuti kucherechedzwa kwekudzikiswa kwemusiyano mune zvinoreva FA pakati pemasampuli maviri anogona kunge ari chinhu chakagara chiripo kana mhedzisiro yekuvandudzwa kweCSBD. Dambudziko iri rinokanganisa zvimwe zvakawanda zvidzidzo zveatomical kana inoshanda kwehuropi misiyano uchishandisa muchinjikwa chikamu chikamu dhizaini (Yuan et al., 2010). Yakareba dhizaini inodiwa kuti uongorore basa rehuropi shanduko sezvavanobatana nekusimudzira uye kufambira mberi kwezviratidzo zveCSBD.
Kumwe kumisikidzwa kunoenderana nekutora kwevatori vechikamu veCSBD, izvo zvaikonzerwa neHypersexual Disorder (HD; Kafka, 2010), kwete ICD-11 maitiro, sezvo data redu rakaunganidzwa kusati kwaburitswa bhuku idzva reWHO. Maitiro ane chekuita nekushushikana uye nemanzwiro emutemo aripo pakati peiyo HD, asi kwete CSBD tsananguro (ona Gola et al., 2020), saka yedu yemakiriniki sampuro inogona kunge yakafanana nevakawanda veODD. Zvinotonyanya kukosha, sampuro yedu yaive diki uye ese mapoka aive nevarume vega vehukadzi vezera rakafanana, vagari vePoland. Mune ramangwana zvidzidzo zveiyo neurobiological hwaro hweCSBD, yakakura uye yakawanda mhando dzakasiyana dzinoda kutorwa. Saizi diki yemuenzaniso inogona kuve chikonzero nei mhedzisiro yedu isina kupona iyo yakasarudzika FWE kururamisa, uye ichi chimwezve chipimo chekudzidza. Zvakare, kuenzanisa kwakananga kune vanhu vane kupindwa muropa uye OCD (pane kungoita mhinduro dzakanyorwa mumabhuku) inogona kutsigira mhedziso dzakasimba muzvidzidzo zvenguva yemberi.
mhedziso
Zvigumisiro zvekudzidza kwedu zvinoratidza kuti CSBD inogovera maitiro akafanana ezvakaipa pamwe neOCD uye kupindwa muropa. Zvichienzaniswa nekudzora, vanhu veCSBD vakaratidza kukosha kweFA kuderera mune yepamusoro corona radiata turakiti, yemukati kapuleti turakiti, cerebellar maturakiti uye occipital gyrus chena nyaya. Seimwe yeiyo yekutanga DTI kudzidza kuenzanisa mamiro ehuropi misiyano pakati peCSBD, kupindwa muropa uye OCD, kunyangwe ichiratidza zvinhu zvitsva zveCSBD, haina kukwana kuona kana CSBD yakafanana neakawanda kupindwa muropa kana OCD. Kuenderera mberi nekutsvagisa, kunyanya kuenzanisa chaiko vanhu vane matambudziko ese matatu kunogona kupa mhedzisiro yakajeka.
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