Psychopharmacology (Berl). 2019 May 9. doi: 10.1007 / s00213-019-05259-3.
inahaneloang
RATIONALE:
Lefu la tsoekere le na le monyetla oa ho eketsa ho fetisoa hoa phepelo ea monoaminergic libakeng tsa boithabiso le tsa meputso ea kelello. Insulin dysfunction triggered synaptic monoamine deficit e amahanngoa le ho nona ho feta tekano le takatso ea kelello e amanang le phetoho ho bakuli ba lefu la tsoekere. Tsoekere e nkang tsoekere (saccharin) ke monko o monate o sa tlatsang oa caloric o ka felisang mathata a kelello ho lefu la tsoekere.
LIPOTSO:
Thutong ea hajoale, ho ile ha hlahlojoa litla-morao tsa ho fufuleloa le ho ts'oaroa ha tsoekere ka mofuta oa tsoekere le mofuta oa ho tšoenyeha ka mofuta oa litoeba tsa lefu la tsoekere la 2.
LITLHAHISO:
Litoeba tsa Switzerland tsa albino li ile tsa entoa ka streptozotocin (135 mg / kg). Kamora ho kenoa ke lefu la tsoekere, litoeba li ile tsa pepesetsoa metsi a metsi a libotlolo tse peli, 10% ea metsi a sucrose, kapa paradigm ea khetho ea metsi ea 10% matsatsi a 28. Ho ile ha sebelisoa lihlopha tse arohaneng ho lekola phello ea ho hula ha sucrose kapa saccharin ho litoeba tsa lefu la tsoekere. Monoamine oxidase (MAO), corticosterone, thiobarbituric acid e sebetsang lintho (TBARS), le ho fokotsa glutathione (GSH) li lekantsoe kamora liteko tsa boits'oaro.
LIKOTSO:
Litoeba tsa lefu la tsoekere li bonahetse thato ea 10% sucrose kapa saccharin ka holim'a metsi. Ho fokotsa ho ja ho feta ke litoeba tsa lefu la tsoekere ho holofatsang matšoao a khatello ea maikutlo le ho tšoenyeha; leha ho le joalo, ho khaotsa ho ile ha mpefatsa liketso tsena tse mpe tsa boitšoaro. Ho ts'oaroa ha sucrose ke 10% saccharin ho kentse mokhoa o nyahamisang le o ts'oenyehileng joalo ka ho bapisoa le litoeba tsa lefu la tsoekere tse pepesitsoeng ka thoko ho metsi-a metsi kapa a sucrose-metsi a le mong, le mabapi le litoeba tse tloaelehileng. Leha ho ikarola ho sa kopaneng le boits'oaro ba lischarin ho litoeba tsa lefu la tsoekere, leha ho le joalo, tsena li ne li le tlase haholo ha li bapisoa le ho ikhula ho sucrose kapa sehlopha se tloaelehileng. Ho hlakisoa hape ha matšoao a lischarin a felisitsoeng a khatello ea maikutlo le matšoenyeho a litoeba tsa lefu la tsoekere.
QETELLO:
Likhetho tsa likamano tse matlafatsang tsa mokokotlo nakong ea sescharin li fokotsa boitšoaro bo sithabetsang le ba ho tšoenyeha nakong ea lefu la tsoekere.
LIHLOOHO: Tšoenyeha; Corticosterone; Ho tepella maikutlo; Lefu la tsoekere; Monoamine oxidase; Ho imeloa kelellong; Saccharin; Sucrose
PMID: 31073738
DOI: 10.1007/s00213-019-05259-3
;