Neurosci Lett. 2019 Jun 11: 134328. Doi: 10.1016 / j.neulet.2019.134328.
Bozorgmehr A.1, Mofumahali F2, Sadeghi B3, Shahbazi A4, Ofogh SN4, Joghataei MT5, Razian S6, Heydari F.7, Ghadirivasfi M8.
inahaneloang
Sisteme ea oxytocinergic e susumetsa leeme le lebisang tlhokomelong ea maikutlo le ho ithuta ka maikutlo. Ha re nahana ka tag ea single-nucleotide polymorphism (SNP) e fumanoeng ka ho sekaseka mofuta o sa tloaelehang oa haplotype liphatseng tsa oxytocin receptor (OXTR), re ile ra fuputsa phello ea oxytocin ha ho etsoa liqeto tse kotsi ka Iowa Gambling Task (IGT). Banna ba batona ba phetseng hantle ba ile ba fumana intranasal oxytocin kapa placebo, mme IGT e ile ea etsoa moo ho tlalehiloeng lintlha tse tala, lintlha tsa nete le nako e felletseng, mme karolelano ea melemo ho likhetho tse seng ntle e baliloe. Ho sebelisa PCR-pyrosequencing, 761 bp target sequence ho OXTR gene e ile ea eketsoa mme ea latellana kamora ho ntšoa ha DNA e felletseng ea mali. Ho sebelisa mohlala oa Haploview, haplotypes le linkage disequilibrium (LD) har'a li-SNP tsohle tse 14 tse sebakeng sa intronic li ile tsa khethoa ho ipapisitsoe le boleng ba D 'le LOD, mme rs2254295 e nang le LD e phahameng ka ho fetisisa e bontšitsoe e le tag SNP. GTT e bonts'itsoe hore e na le maqhubu a phahameng ka ho fetisisa har'a li-haplotypes tse fumanoeng. Sehlopha sa Oxytocin le bankakarolo ba nang le mofuta oa mofuta oa TT ba bonts'itse lintlha tse ntseng li eketseha haholo, lintlha tsa nete le likhetho tse ntle, athe nako eohle ha ea ka ea susumetsoa ka mokhoa o makatsang. Sena se bolela hore oxytocin e fokolitse haholo kotsi ea ho nka liqeto, mme bankakarolo ba mofuta oa TT ba ne ba na le liqeto tse tlase pele ho nako kapa tse kotsi ho feta ba nang le li-genotypes tsa CT le CC. rs2254295 e ka hlophisa ts'ebetso kapa polelo ea lefutso la OXTR, ho bolelang hore T allele e ka eketsa polelo ea lefutso la OXTR ha e bapisoa le C allele. Re fana ka tlhahiso ea hore oxytocin e ka lekanyetsa ka mokhoa o makatsang boemo ba kotsi le litlamorao tsa eona nakong ea ho etsa liqeto tse sa tsitsang.
LINKOTSO: Ho etsa liqeto; Mosebetsi oa ho becha oa Iowa; Li-polymorphisms tsa OXTR; Oxetocin; Karabelo ea ketane ea polymerase
PMID: 31200092