Behav Neurosci. 2013 Jun;127(3):458-64. doi: 10.1037/a0032332.
Garduño-Gutiérrez R, Guadarrama-Bazante L, Lelea-Olea M, Rodríguez-Manzo G.
mohloli o moholo
Departamento de Farmacobiología, Cinvestav Sede Sur, Cinvestav Sede Sur, Motse oa México, México.
inahaneloang
Ejaculation e khothaletsa tokollo ea endo native opioid. Tšusumetso ea ho tepella e hlahisa liphetoho tse ngata tsa boits'oaro le 'mele, tseo ho tsona boitšoaro bo sa feleng bo amanang le thobalano le boitsibollo bo akaretsang bo tsebahalang haholo. Hobane ho ikopanya le mokhathala ho kenyelletsa kemolo e mengata e latellanang, mosebetsing ona re khothalelitse hore li-opioid tsa nako e telele tse tsoang li-ejotsoations tse ngata nakong ea ts'usumetso ea ts'ebetso ea mokhathala li ka fetola liphetoho tse boletsoeng ka holimo tsa thobalano. Ho etsa tlhahlobo ea maikutlo ana, litoeba tsa banna ba nang le thobalano li ile tsa kenngoa le opioid receptor antagonist naltrexone pele ho ts'ebetso ea ho khathala mme ba lekoa bakeng sa boitšoaro ba thobalano kapa hypersensitivity 24 h hamorao. Qetellong ho ile ha hlahlojoa ponahalo ea letšoao le tsitsitseng la 'mele oa serotonergic, ha a arabela litekanyetso tsa 5-hydroxytryptamine-1A (5-HT1A) receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin ( 8-OH-DPAT), e tlase ho ba tloaetseng ho kenya lets'oao lena. Kameho ea ho fana ka naltrexone ho liphoofolo tse seng li ntse li imetsoe ka thobalano (ke hore, 24 h kamora ts'ebetso ea satiation ea thobalano) ho likarabo ka bobeli le eona e ile ea lekoa.
Liphetho li bonts'itse hore li-opioid tsa mehleng ea khale li kena lipakeng ho theha le ho boloka thibelo ea boitšoaro ba nako e telele ea thobalano empa eseng lithethefatsi hypersensitivity (ho 8-OH-DPAT) tšobotsi ea likotsi tsa banna tse tepelletseng ka thobalano. Ho phethoa hore le ha liketsahalo tsena ka bobeli li hlaha e le sephetho sa ho ikopanya le ho sata le ho latela nako e ts'oanang ea ho hlaphoheloa, ba li hlahisoa ke mekhoa e ikhethileng.
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