Neuropsychopharmacology. 2015 Feb 18. Doi: 10.1038 / npp.2015.45.
Ferris MJ1, Calipari ES1, Rose JH1, Siciliano CA1, Letsatsi H1, Chen R1, Jones SR1.
inahaneloang
Ho na le batho ba ka bang limilione tse 1.6 ba fihlelang litekanyetso tsa ho lemalla koae United States, 'me hajoale ha ho na li-pharmacotherapies tse amoheloang ke FDA. Lithethefatsi tse lokollang dopamine tse thehiloeng ho amphetamine li bontšitse ho sebetsa hantle bakeng sa ho fokotsa tšusumetso ea ho ithaopela ho sebelisa koae le ho fokotsa ho ja liphoofolo le batho. Ho nahanoa hore amphetamine e sebetsa e le pheko ea phepelo ea koae ka ho phahamisa maemo a dopamine ea extracellular.
Re sebelisa voltammetry melaleng ea bokong, re lekile bokhoni ba ts'oaetso e le 'ngoe ea amphetamine ho vivo ho fetolela ho lokolloa ha dopamine, uptake kinetics, le potency ea cocaine liphoofolong tsa cocaine naïve le kamora ho ba le nalane ea boikoetliso ba koae (1.5 mg / kg / kg / infusion, e tsitsitseng -ratio 1, liente tsa 40 / matsatsi a x 5). Dopamine kinetics e ne e lekantsoe lihora tsa 1 le 24 kamora lihora tsa amphetamine (0.56 mg / kg, iv). Ka mor'a ho itaola ka tsela e nang le koae, ho lokolloa ha dopamine, sekhahla se phahameng sa phetoho (V, max), le maemo a amanang le dopamine transporter (DAT) a amanang le membrane a ile a fokotsoa, 'me DAT e ne e sa amehe haholo ka koae. Ho ts'oaroa ha amphetamine e le 'ngoe ho fokolitse V, max le maemo a membrane a DAT ho liphoofolo tsa cocaine naïve, empa a khutlisetse ka botlalo likarolo tsohle tsa ts'ebetso ea dopamine terminal ho liphoofolo tse ikatisang tsa koae.
Mona, ka lekhetlo la pele, re bonts'a ts'ebetso ea lithethefatsi, pholoso e potlakileng ea bofokoli mosebetsing oa dopamine nerve-terminal liphoofolong tse nang le nalane ea taolo e phahameng ea koae. Tlhatlhobo ena e ts'ehetsa taba ea hore polelo ea DAT le ts'ebetso e ka fetoloa ka nako e potlakileng mme e boetse e fana ka maikutlo a hore liketso tsa pharmacotherapeic tsa amphetamine bakeng sa ts'ebeliso ea lithethefatsi tsa koae li fetela ka n that'ane ho tsa kalafo.
;
