Litlhaloso tsa Gary:
- Bakeng sa li-erections, li-receptor tse fapaneng tsa dopamine li sebelisoa (le libaka tse fapaneng tse hlahisoang ke oxytocin) ho itšetlehile ka hore na mosali ea amohelang o teng kapa che. Na ho ka bolela hore ho itšireletsa ho fapana le ts'oaetso ea molekane - moo libaka tsa oxytocin li kentsoeng teng.
- Thuto e senola hore lisele tsa oxytocin li na le li-receptor tsa dopamine. Kahoo dopamine e baka ho eketseha ha oxytocin.
Baskerville TA, Allard J, Wayman C, Douglas AJ.
Eur J Neurosci. 2009 Dec 3; 30 (11): 2151-64. Epub 2009 Nov 25.
Setsi sa Physiology e Kopanetsoeng, Sekolo sa Boitsebiso ba Bohlale, Univesithi ea Edinburgh, Edinburgh, EH8 9XD, UK.
Dopamine le oktotocin li thehile boikarabello ba molao o bohareng oa penile erection ka likhoto; Leha ho le joalo, litšebeletso tsa neural tse kenang moelelong o itseng oa erectile le ho sebelisana pakeng tsa dopamine le oxytocin mekhoa e sa ntse e lokela ho hlakisoa.
Sebaka sa lipakeng tsa pele-pele (MPOA), khalase ea supraoptic (SON) le khalase ea pharalegia (PVN) ea hypothalamus e ka sebetsa e le libaka tsa li-candidate hobane li na le lisele tsa oxytocin, li fumana mekhoa ea dopaminergic 'me li kentse letsoho tabeng ea ho loantša boitšoaro bo bobe ba ho kopanela liphate.
Makhetlo a mabeli a immunofluorescence a senola hore lisele tse ngata tsa oxytocin tse MPOA, SON le PVN li na le dopamine D (2), D (3) le D (4) receptors.
Likokoanyana tse sa tsitsitseng, li sebelisa matla a mangata a se nang mokokotlo e le mokhoa oa ho fetoha, ho thibeloa ha lumbosacral oxytocin receptors (UK, 427843) ho fokotsoe likarabo tsa erectile ho nonselective dopamine agonist (apomorphine), e leng se bontšang hore dopamine e fumana paraventriculospinal oxytocin tsela.
Ha banna ba sa tsebe hore na ho na le basali ba mofuta ofe, pentele erection e entsoeng ke D (2) / D (3) (Quinelorane) empa e se D (4) (PD168077) ea agonist e ne e amahanngoa le ho sebelisoa ha lisele tsa PVN oxytocin tsa parvocellular.
Ka tlhahlobo e 'ngoe eo banna ba fuoeng ho fihlela ka botlalo ho basali ba amohelehang, e leng D (4) (L-745870) empa e se D (2) kapa D (3) mohanyetsi (L-741626; nafadotride) e thibelitse penile erection (tlhahiso-pele) 'me sena se ne se amana le activation ea SON magnocellular oxytocin neuron.
Hammoho, data e bontša Litholoana tsa dopamine liseleng tsa hypothalamic oxytocin nakong ea penile erection li totobetse moelelong.
Dopamine e ka sebetsa ka li-parvocellular le magnocellular oxytocin tse fapaneng ho hlahisa likarabo tsa erectile, ho itšetlehile ka hore na ho fokotsa ho hong ho etsoa.
Phuputso ena e bonts'a hore ho ka etsahala hore ho be le puisano pakeng tsa dopamine le tsela ea oxytocin nakong ea ha ho etsoa penile, le SONA le PVN e le libaka tse kenyelletsoeng.
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