Ntlafatso ea Bongobo Nakong ea Bocha ba Bocha (2013)

Dtsch Arztebl Int. Jun 2013; 110 (25): 425-431.

E hatisitsoe Inthaneteng Jun 21, 2013. doi:  10.3238 / arztebl.2013.0425
PMCID: PMC3705203
Tlhahlobo ea Tlhahlobo
Lintlha tsa Neurosci science Ho kena Nakong ena ea Nts'etsopele
Kerstin Konrad, Moprof. Dr. rer. nat.,*,1 Christine Firk, Dr. PhD,2 'me Peter J Uhlhaas, Ngaka PhD3
Bona lengolo “Bongoli (karabo): Karabo”Leqepheng la 733b.
Sehlooho sena se bile teng e boletsoeng ke lihlooho tse ling ho PMC.

inahaneloang

Background

Nako ea bocha ke karolo ea bophelo lipakeng tsa bongoana le ho ba motho e moholo. Ka tloaelo, bacha ba batla ho fapakana, liphihlelo tse ncha le maikutlo a matla, ka linako tse ling ba beha bophelo ba bona bo botle kotsing. Ka mohlala, naheng ea Jeremane, 62% ea batho bohle ba shoang har'a batho ba nang le lilemo tsa 15 ho 20 e bakiloe ke likotsi tse mpe. Litlhaloso tsa neurosciology li hlahisitsoe ka mokhoa o tloaelehileng oa bocha; ka litlhaloso tsena kelellong, motho a ka fumana mekhoa e nepahetseng ea ho sebetsana le bacha.

Method

Ka boithuto re hlahloba lintlha tse amanang le tse fumanehang ho database ea PubMed mabapi le tlhabollo ea methapo ea kelello bocheng ba hae.

Results

Liphumano tse ncha ho psychology ea nts'etsopele le neuroscience li senola hore karolo ea mantlha ea kelello e hlophisitsoeng e etsahala bongoaneng. Ka kholiseho ea bongoana kamora ho pepa, boholo ba ntho e bohlooho bo fihlella pele ho sensorimotor cortex ea mantlha, 'me kh'olo ea pele ea cortex e ba ea ho qetela. Libaka tsa kelello tsa subcortical, haholo ts'ebetso ea limbic le sistimi ea moputso, lia hola pejana, e le hore ho be le ho se lekane nakong ea bocha pakeng tsa libaka tse hloahloa tsa subcortical le libaka tse sa holofetseng tsa pele. Sena se ka ikarabella bakeng sa mekhoa e tloahelehileng ea bocha ea boitšoaro, ho kenyeletsa le ho ipeha kotsing.

fihlela qeto e

Botebo bo phahameng ba boko ba bongoana bo lumella litšusumetso tsa tikoloho ho fana ka litlamorao tse matla ho potoloho ea cortical. Le ha hona ho etsa hore kelello le maikutlo li ntlafale, ho boetse ho bula mamati a litšusumetso tse ka bang kotsi.

Nako ea bocha ke karolo ea bophelo lipakeng tsa bongoana le ho ba motho e moholo. Ha se nako ea ho fetoha 'mele feela, empa le nako ea ho holisa kelello le maikutlo hore e be motho ea ikemetseng ea nang le boikarabelo. Mesebetsi e meholo ea nts'etsopele ea bohlankana e kenyelletsa ho theha le ho holisa likamano tse haufi-ufi le nts'etsopele ea boitsebahatso, maikutlo a nako e tlang, boipuso, boitšepo, boits'oaro, le bokhoni ba boiketlo ba sechaba (1).

O ile a hlokomela boitšoaro bo behang kotsing

Bacha ba bangata le batho ba baholo ba bacha ba tloaetse ho ipeha kotsing ebile ba thabela ho ba le maikutlo a feteletseng (2, 3). Sena se bonahala lipalo-palo tse bonts'ang hore boitšoaro bo kotsi bocheng bo hokahane le kotsi e phahameng ea bophelo bo botle (4). Ka mohlala, naheng ea Jeremane, 62% ea batho bohle ba shoang har'a batho ba nang le lilemo tsa 15 ho 20 e bakiloe ke likotsi tse mpe. Lisosa tse tloaelehileng tsa lefu ke likotsi tsa koloi, likotsi tse ling, pefo le ho intša kotsi (5). Polao e phahameng e bakoa ke ho khanna ho tahoa, ho khanna ntle le setulo, ho jara libetsa, tšebeliso e mpe ea lithethefatsi le thobalano e sa sireletsehang (4).

Bashemane le banana ha ba bapisoa

Joalokaha re ka bona ho Lethathamo, bashanyana le banana ba etsa lintho tse kotsi ka linako tse tšoanang. Ka mohlala, lilemong tsa morao tjena, keketseho ea ho tsuba ho bashanyana le banana e batla e lekana, leha ho na le liphapang tse ling tse loketseng: Bashemane ba tsuba lisakerete tse ngata, hape ba tsuba koae e "thata haholo" lintho tse kang koae, koae e ntšo, le koae e sa koaeloang. Bashemane le banana ba boetse ba noa lino tse fapaneng tsa joala: Bashemane ba tloaetse ho noa biri le joala bo thata, ha banana ba tloaetse ho noa veine, veine e phophomang, joalo-joalo. Ba boetse ba sebelisa lithethefatsi tse seng molaong hangata ho feta banana. Bashemane ba tloaetse ho tsoa likotsi, 'me ba ipeha kotsing e ngata ha ba khanna. Banana ka lehlakoreng le leng, ba na le menyetla ea ho beha bophelo bo botle sebakeng sa phepo (mohlala, ho ja, mathata a ho ja).

Lethathamo 

Boitšoaro bo kotsi har'a bacha ba Jeremane, ka liperesente

Method

Tlhahlobo ena e ama leseli le lecha la methapo ea kutlo boits'oarong ba bocha le litlamorao tsa mekhoa e metle ea ho sebetsana le bacha. Re ithutile litaba tsena ka mokhoa o ikhethileng oa ho batla lingoliloeng tse loketseng libukeng tsa laebrari ea Jeremane, sebakeng sa database sa PubMed re sebelisa mantsoe a ho batla "bohlankana kapa boroetsana," "bongo / neural" le "nts'etsopele." Lingoloang tse bontšitsoeng le tsona li ile tsa nkuoa. Ho ile ha lebisoa tlhokomelo e khethehileng lithutong tsa litoro tsa batho tsa neano.

Background

Ho fihlela lilemong tse 'maloa tse fetileng, ho ne ho e-na le monahano o akaretsang oa nts'etsopele ea kelello le neuroscience hore liphetoho tse kholo kahong ea meaho le tšebetso ea boko li ile tsa lekanyetsoa ho nako ea bokhachane le lilemo tse hlano kapa tse tšeletseng tsa bophelo. (Bakeng sa setšoantšo se akaretsang, bona [6].) Leha ho le joalo, ho sa le joalo, lintho tse ncha tse fumanoeng tsa mahlale li qobelletse ntlafatso ea mohopolo ona.

Boithuto bo boholo ba nako e telele bo bontšitse hore ho hlophisoa bocha ha kelello ho etsahala nakong ea bocha (7). Li-synapses tse ngata li felisitsoe (8) athe, ka nako e ts'oanang, ho na le keketseho ea taba e tšoeu (9, 10), mme ho na le liphetoho lits'ebetsong tsa methapo ea kutlo le (11, e1, e2). Kahoo, lits'ebetso tsa ho fetoha ha mmele tsa bocha tse etsahalang bongoaneng li matla haholo ho feta kamoo ho neng ho hopotsoe ka teng qalong. Ho ka phethoa hore ho hlophisoa bocha ha li-cortical circuits ho etsahala lilemong tsa bocha mme ho bonahala ka liphetoho tsa ts'ebetso ea kelello le ho ama melaoana e tloaelehileng ea nako ena ea bophelo (12).

Ho khahlisang, mokhoa ona oa ho holisa boko ba motho o fapana le oa mofuta oa khale oa batho. Leha, ka mohlala, litšoene tsa rhesus le lichimpanzi (joalo ka batho) li tsoaloa li na le masapo a mmele, libaka tsohle tsa boko ba macaques li holile ka tekanyo e le 'ngoe (13). Ho motho, lithuto tsa autopsy li bonts'itse hore li-synaptogenesis li fihla hofihlella ka har'a li-cortices tse bonoang le tse ngolang likhoeli tse 'maloa ka mor'a ho beleha, ha li-synapses li thehoa butle butle ho cortex ea pele. Ka hona, nakong ea kholo ea batho, ho bile le phetoho ho tloha ka tatellano ho ea ho heterochronous patterns of cortical development (8). Ts'ebetso ena e tsoetseng pele ea nts'etsopele e nolofalletsa nts'etsopele ea bokhoni ba batho, haholoholo bo fumanoeng ka ho kenella tikolohong e tsosang takatso ea sechaba, mohlala, ka ho kena sekolo, mmino, puisano ka mantsoe le ts'ebelisanong ea sechaba (14) (Setšoantšo sa 1).

Setšoantšo sa 1 

Nts'etsopele ea cortex ea pele e ka hlaha ho monna ha e bapisoa le li-primates tse ling. Setšoantšo se bontša letsoalo la synaptic ka 100 µm2 sethaleng sa pele e le ts'ebetso ea botsitso ho motho (bofubelu), lichimpanzi (boputsoa), le rhesus macaques (mohloaare ...

Kutloisiso ea hajoale ea nts'etsopele ea boko bongoaneng

Sebopeho sa boko

Boko bo hōlile ka botlalo haufinyane kamora ho hlaha, ka kutloisiso ea hore khetla ea "cerebral cortex" e fihla molomong oa eona o moholo. Le ha ho le joalo, lits'ebetso tsa bohlokoa tsa ntlafatso ea methapo li ntse li etsahala bongoaneng, joalo ka ha lipatlisiso tsa sebopeho sa monahano se bontšitse (15, e3- e5). Bophelong, taba ea bohlooho e ea holima ho tloha ka morao ho ea pele, ka mantsoe a mang: Tekano e phahameng ea bohlooho e fihlella pele ho cortex ea sensorimotor ea mantlha le ea ho qetela libakeng tse hloahloa tsa kopano tse kang dorsolateral prefrontal cortex, prenetal gyrus e tlase, le sebapali se phahameng ka ho fetisisa sa nakoana. Sena se bolela hore, haholo-holo, likarolo tsa boko tse joalo ka cortex ea pele-e fanang ka tšebetso e phahameng joalo ka taolo ea boitšoaro, ho rala le ho lekola likotsi tsa liqeto -o holileng tsebong kamora libaka tse amanang le methapo ea kutlo le motor (16) (Setšoantšo sa 2).

Setšoantšo sa 2 

Nts'etsopele ea taba e tšoeu le bohlooho ba pelepele ka nako ea bophelo ba motho; arola li-curve bakeng sa bong ka bong. Ho tloha (7) Giedd JN, et al: Nts'etsopele ea bongoana nakong ea bongoana le bohlankana: thuto e telele ea MRI. Natural Neuroscience 1999; ...

Liphumano tsa Autopsy li bonts'a hore liphetoho tsena tsa taba e putsoa li bakoa ke ho roka ha synaptic (17). Li-synapss tse ngata li thehoa bongoaneng tseo hamorao li tlosoang bohlankaneng. Sena se etsahala ka tsela e itšetlehileng ka boiphihlelo, ke ho re, li-synapses tse ntseng li phela ke tsona tse atisang ho "sebelisoa." Ho boetse ho na le mekhoa e meng ea maqhubu e ka bakang liphetoho tsa taba molemong oa bophelo, mohlala, phokotso. palong ea lisele tsa glial le keketseho ea myelination (18).

Ha taba e putsoa e fokotseha ka bongata, taba e tšoeu e eketseha ka molumo. Taba e tšoeu e entsoe ka li-axon tsa myelinated tse tsamaisang tlhaiso-leseling ea neural ka potlako. Molumo oa taba e tšoeu o eketseha ho tloha bongoaneng ho fihlela motho e moholo.19). Katoloso ena e nkuoa e ka tlameha, ka karolo e kholo, ho emelting ea axon e tsoelang pele ke oligodendrocyte (10). Myelination e atisa ho hlaha ho tloha tlase ho isa libakeng tse phahameng tsa bokong, le ho tloha kamoreng e ka morao ho ea kantle.

Ts'ebetso ea boko

Mekhoa ea ho hlophisa bocha ea bongoana e hlalositsoeng kaholimo e amana le liphetoho tse tebileng tsa maikutlo le kelello. Haholo-holo, ho na le tsoelo-pele e tsoelang pele ea mesebetsi ea botsamaisi, ke hore, ts'ebetso ea kelello e laolang mohopolo le boits'oaro mme ka tsela eo e lumelle motho ho ikamahanya le maemo hore e be mesebetsi e mecha e rarahaneng (20). Bocheng, ka nako e ts'oanang moo mahlale ana a bonohe a ntseng a ntlafatsoa, ​​ho boetse ho na le liphetoho lipapatsong tse amanang le boiketlo ba motho joaloka ho tsebahala sefahleho, seo ho thoeng ke mohopolo oa kelello (ke hore, bokhoni ba ho ipeha kelellong sebakeng sa motho e mong). le kutloelo-bohloko (21).

Boemong ba neural, lithuto tsa ho nahana ka tšebetso tsa nts'etsopele ea boko li bontšitse hore bana le bacha ba atisa ho ba le mokhoa o pharaletseng, o sa tsepamiseng maikutlo ho feta batho ba baholo, le hore ts'ebetso e ntle ea ho fumana lisebelisoa tsa neural e eketseha ka lilemo, e le hore ts'ebetso ea neural e fokotseha libakeng tsa boko tse ling. ho feta tse amanang le mosebetsi o haufi (22). Ha ho e-so hlake hore na mokhoa ona oa ntlafatso ea neural o bakiloe ke eng ka lebaka la ts'usumetso ea boiphihlelo kapa ea tlhaho. Boithuto ba ho ts'oara bo boetse bo bonts'a hore bacha ba phahamisitse ts'ebetso libakeng tse nang le matsoho maemong a maikutlo: Mohlala, Galvan et al. (23) e fumane hore tebello ea moputso e amahanngoa le ts'ebetso e tšoailoeng ho li-nucleus tse bokellaneng ho bacha ho feta ho bana le batho ba baholo. Ho khahlisang, bafuputsi bana ba boetse ba fumane kamano e ntle lipakeng tsa ts'ebetso ho li-nucleus bokellanang le tšekamelo ea motho ka mong ea ho beha bacha kotsing (24).

Ntle le moo, lithuto tsa ho nahana ka sebopeho le tšebetso li bonts'itse hore cortex ea pele-pele e hokahana ka matla le likarolo tsa maikutlo le tsa bohlasoa nakong ea bocha.25, 26, e6). Sena se bolela tšusumetso e kholo ea libaka tsa boko ba ka pele lits'ebetsong tsa kelello le tse amanang. Nts'etsopele ea li-circuits tsa kelello le tse amanang le tsona ha ea lokela ho nkuoa e le eona feela moelelo oa ntlafalo ea methapo ea methapo; empa, ho bonahala ho na le tšebelisano e matla ea lintlha tsa liphatsa tsa lefutso ka litlhoko tsa tikoloho. Mohlala, ama melaoana 'me methapo ea boko e fanang ka eona e susumetsoa ke tšebelisano ea motsoali le ngoana (27).

Liphumano tse ling tse bonts'ang hore ho hlophisoa bocha ha neural circry ho etsahala lilemong tsa bocha ho nkiloe liphuputsong tsa motlakase, ho kenyelletsa le lithuto tsa electroencephalographic (EEG) tsa liphetoho tse maqhubu a maqhubu a phahameng le a maqhubu a kelello (28). Kholiso ea methapo bocheng e amana le ho theoha hoa tšebetso ea oscillatory phomolong ea li-delta (0-3 Hz) le li-theta (4-7 Hz), le keketseho ea lihlopha tsa alpha (8-12 Hz) le lihlopha tsa beta (13 –30 Hz). Ka li-oscillations tse itšetlehileng ka mosebetsi, ho nepahala ha tumellano ea liketsahalo tsa oscillatory ho tsa theta, alpha, le lihlopha tsa beta lia eketseha. Nts'etsopele ea morao-rao ea li-oscillations tse kopaneng lilemong tsa bocha li hokahane haholo le mekhoa ea ho feto-fetoha ha sebopeho (anatomical) hammoho le liphetoho tsa mantlha lits'ebetsong tsa neurotransmitter, tse entsoeng lipatlisiso tse tebileng lilemong tse 'maloa tse fetileng.

Tlhaloso ea methapo ea kutlo mabapi le boitšoaro bo tloaelehileng ba bongoaneng

E 'ngoe ea mehlala e nang le tšusumetso e matla ea neurobiological ea ho hlalosa boitšoaro bo tloaelehileng ba bongoana e ntlafalitsoe ke sehlopha sa Casey New York (29, e7) (Setšoantšo sa 3).

Setšoantšo sa 3 

Lits'ebetso tse se nang moeli tsa likarolo tsa bongo tsa subcortical le pele li lebisa ho se leka-lekanang ha marangrang a neural bohlankaneng. E fetotsoe ho tsoa ho (12) Casey BJ, Jones RM, Hare TA: Boko ba bongoana. Liphatlalatso tsa New York Academy of Sciences 2008; 1124: ...

Tlhahiso ea mantlha ea mohlala ona, e thehiloe ho liphetho tsa neuroanatomical le datha ho tsoa lithutong tse ntle tsa monahano (23, 24, 30, 31), ke hore lilemong tsa bocha ke nako ea ho se leka-lekane ha tlhaho ho bakoang ke ho fetoha ha maemo a mantlha a boko le ho potlaka ho fetoloang ha libaka tsa taolo ea pele (Setšoantšo sa 3), ka lebaka la hore, maemong a maikutlo, lits'ebetso tse holima botsitso le meputso li matlafala, ka mantsoe a mang, holim'a ts'ebetso ea taolo e sa le pele e sa. Sena ha sea lokela ho nkoa ho bolela hore ka tlhaho bacha ha ba khone ho etsa liqeto tse nepahetseng. Ho fapana le moo, maemong a imeloang haholo maikutlong (mohlala, ka pel'a bacha ba bang kapa ha ho na le tebello ea moputso), monyetla o hlaha oa hore meputso le maikutlo li tla ama boits'oaro ka matla ho feta lits'ebetso tse hlakileng tsa ho etsa liqeto (23, 24, 32). Moetso ona o lekiloe letotong la lithuto tsa liteko (lebokose).

lebokose

Tšusumetso ea lithaka ka boits'oaro bo kotsi

Bafuputsi ba hirile batho ba lihlopheng tse tharo tsa lilemo (13 ho isa lilemong tsa 16, 18 ho lilemo tsa 22, le lilemo tse fetang 24) ho ithuta hore na tšusumetso ea batho ba mehleng ena (lithaka) ka liqeto tse kotsi e its'etleha ho latela lilemo tsa mathata. Barupeluoa ba ile ba kenngoa ka har'a mofuta oa sebapali sa ho khanna moo ba neng ba tlameha ho khanna ka hohle kamoo ho ka khonehang ho fihlela leseli la sephethephethe le fetoha le lefubelu

Faele e kantle e nang le setšoantšo, papiso, joalo-joalo Lebitso la ntho ke Dtsch_Arztebl_Int-110-0425_004.jpg

mme lerako la hlaha. Haeba koloi e sa emisoe kapele, e ile ea thula leboteng, 'me mokhanni a lahleheloa ke lintlha. Barupeluoa e ne e le bona feela kapa ka lihlopha tsa batho ba bararo ho simulator. Banana ba 13- ho isa ho 16 ba fumanoe ba na le monyetla oa ho etsa liqeto tse kotsi ho feta barupeluoa ba lihlopha tse ling, empa ke boteng ba lithaka tsa bona feela. Boitšoaro ba ho khanna ba baholo bo ne bo ikemetse ntle le ho ba teng kapa ho ba sieo ha lithaka (33).

Ho fumanoe, ka mohlala, hore bacha ba ka hlahloba kotsi ea boitšoaro bo itseng feela joalokaha le batho ba baholo ba ka e botsa ha ba botsoa ka bona bukaneng ea lipotso. Ka lehlakoreng le leng, liteko tse sebetsang tsa tlhaho ea tlhaho li bontša ka ho hlaka hore bacha ba etsa liqeto tse kotsi haholo ka lihlopha ho feta kamoo ba etsang ha ba le bang (33). Lebaka le ka etsahala hore, molemong ona, melemo ea boitšoaro bo seng kotsi - ts'ebeliso ea lithaka tsa sechaba — e lekantsoe haholo ho feta kotsi eo ka boyona. Sena se ka amahanngoa le mokhoa o sa amaneng le oa popelo oa libaka tsa mantlha tsa bokong le bokong. Ho latela mofuta ona, lipatlisiso tsa mananeo a thibelo e bontšitse hore mananeo a thehiloeng tsebong a kenyelletsa tsebo ka likotsi ha a sebetse ho feta a shebaneng le melemo ea motho ka mong le thupelong ea bokhoni ba sechaba le ho hanyetsa (34).

Hoa khahla ho botsa hore na ho na le molemo ofe o ka o fumanang haeba o le teng ka lebaka la ho se lekane hoa nakoana lipakeng tsa methapo ea boko. Ho latela pono ea ho iphetola ha lintho, bocha ke nako ea khōlo eo ho eona mocha a fumanang boipuso. Ts'ebetso ena ha e ikhethang ho mefuta ea motho; ho eketseha ho batla bocha le ho eketsa tšebelisano-'moho le batho ba bang ba lilemo tse tšoanang ho ka bonoa mefuta e meng e mengata hape (35). Boitšoaro bo kotsi bathong ba lilemong tsa bocha bo ka bonoa e le sehlahisoa sa tlhaho ea morao-rao ea tlhaho ea tlhaho pakeng tsa ho batla mefuta-futa le liphihlelo tse ncha ("maikutlo a ho batla") ka lehlakoreng le leng, le ha joale e sa le bokhoni ba boitaolo ba ho itaola ka lehlakoreng le leng (2); Morero oa eona e ka ba ho thusa bacha ho tsoa sebakeng sa ts'ireletso ea malapa, e le hore, ka mohlala, ba ka fumana molekane ntle le ba malapa a bona a mantlha. Ho se leka-lekane ha cortex ea pele ho nako ho bonahala eka ho rata mefuta e meng ea ho ithuta le ho tenyetseha (1).

Ebile, ka nako eohle ea bophelo ba motho, mohlomong ho na le lifensetere tse ngata tsa ntšetso-pele tseo ho tsona boko bo lokiselitsoeng hantle bakeng sa mefuta e meng ea boiphihlelo ba ho ithuta. Ho tsoa ponong ea kholo ea ho iphetola ha lintho, mokhoa oa bonohe o tloaelehileng oa boroetsana, o shebang maikutlo haholo-holo ka tšusumetso ea maemo a bophelo bo botle ebile o fetoha habonolo ha a fana ka lipehelo tsa mantlha, a ka tšoaneloa hantle mesebetsing ea ntšetso-pele ea sechaba e shebileng mocha. Hona hape ho bolela hore kelello ea motho e moholo e ke ke ea nkuoa e le sistimi e sebetsang ka botlalo, le hore nako ea bocha ha ea lokela ho nkuoa e le boemo ba ho se sebetse hantle hoa bokong.

Tšusumetso ea li-hormone tsa "pubertal" nts'etsopele ea bongoaneng ea bongoana

Ho feto-fetoha ha maemo a kemiso nakong ea ho kena bohlankaneng ho tsamaisana le ho eketseha ha li-hormone tsa gonadal steroid. Boko bo na le letsoalo le phahameng la li-receptor tsa steroid, ka hona ho a utloahala hore lihormone tsa thobalano li na le tšusumetso ho marang-rang a neural lilemong tsa bocha. Sisk le Foster (36, e8) ba khothalelitse hore leqhubu la bobeli la ntlafatso ea likhoerekhoere le hlahe lilemong tsa bocha, ho aha ka karolo ea pejana, ea pherekano ea phapang ea thobalano. Ho ea ka mohlala ona, lihormone tsa ho kena bohlankaneng li ama sebopeho se eketsehileng sa boko ba bocha, e le hore tlhophiso e hlophisitsoeng ea boko bo sa feleng e hlahise litholoana, ka hore marang-rang a neural a nolofalitsoe ho kenya tšebetsong litlamorao tsa li-hormone. Khatello ea maikutlo e ntseng e eketseha ea lihormone tsa pubertal e na le litlamorao tse fapaneng ho li-axis tse ntseng li eketseha tsa hypothalamic-pituitary-adrenal (HPA) ho bashanyana le banana: Ho phahama ha li-androgen ho bashanyana ho bonahala ho thibela sechertion ea hypothalamic ea corticotropin-ikokolla li-hormone. laola axis ea HPA ho ea holimo. Li-estrogens li ka etsa hore banana ba tšoenyehe haholo khatello ea maikutlo, ha androgens e etsa hore bashanyana ba inehele hape ho eona (37).

Overview

Ho fihlela joale, lipatlisiso mabapi le bongoana li fumane tlhokomelo e matla ho tsoa ho sechaba sa mahlale le mecha ea litaba. Liphumano tsa morao-rao li bonts'a, hore liphetoho tse tsoelang pele tsa kelello le tsa tlhaho ea bocha li na le tšusumetso e matla sebopeho sa mokokotlo le tšebetso. Boko ba ngoana bo lilemong tsa bocha bo feta mokhatlong o mocha oa polasetiki moo lintlha tsa tikoloho li ka bang le litlamorao tse kholo, tse sa feleng ho li-cortical circry. Sena se bula menyetla e mecha ea thuto. Mohlala, ka lona lebaka leo bacha ba susumetsoang habonolo ke maikutlo, ba tla fumana phaello ho tsoa phihlelong ea ho ithuta e etsahalang maemong a monate a maikutlo a etselitsoeng ho koetlisa taolo ea maikutlo. Ka lebaka la boitšoaro bo kotsi bocheng ba motho bo na le motheo oa maikutlo, liteko tsa ho hatella boitšoaro bo joalo li bonahala li sa atleha. Ho ka ba le kahlolo e molemo haholoanyane ho nolofalletsa bacha ho ba le boiphihlelo ba maikutlo sebakeng se bolokehileng, le ho eketsa meputso ea sechaba e amanang le boits'oaro bo seng kotsi ka melao e laoloang (mohlala, thibelo ea mefuta e meng ea papatso) le phano ea mehlala e ntle ea maikutlo. Mohlala, motho ea etellang pele bongoaneng ho opera ea sesepa ea thelevisheneng a ka khetha ho tsoa tlholisano ea joala e thata e hlophisitsoeng ke metsoalle.

Ho feta moo, nako ea protocol ea neural e sa le lilemong tsa bocha le eona e etsa hore bacha ba hlaselehe habonolo ts'usumetso e mpe ea tikoloho, mohlala, lithethefatsi. Liphumano tsa liteko tsa liphoofolo le lithuto tsa batho li fana ka mohlala, hore, tšebeliso ea li-cannabis lilemong tsa bocha li ka baka liphetoho tse sa feleng tsa kelello le liphetoho tsa sebopeho tse ngata haholo ho feta tse bonoang ho basebelisi ba bang ba bang ba bang le kankere.38).

Patlisiso ea bokamoso mabapi le nts'etsopele ea boko e lokela ho rarolla bothata ba bohlokoa ba ts'usumetso ea tikoloho ts'ebetsong le mokhatlong oa boko.

Ho fihlela joale, neuroscience ea kelello ha e so hlahlobe ka botlalo tšusumetso ea maemo a sechaba le setso molemong oa lits'ebetso tsa kelello le tse amanang le kholo ea bona. Ka hona, kutlwisiso ea rona ea hona joale ea hore bongoana ke karolo e nkang qeto boikutlong ba bokong, le hore lits'ebetso tsa ho holisa bohlasoa ba boko li ka sebetsa ho fihlela li le mashome a mabeli, kapa ho feta moo, le tsona li na le bohlokoa ba leano la thuto le la sechaba. Liqeto tsohle tse amang nts'etsopele ea bana le bacha li lokela ho ela hloko lintlha tsa neurobiological. Litaba tse kholo tsa hona joale tsa mofuta ona li kenyelletsa potso ea ho ngolisa tšebeliso ea litlatse ka molao le tšebeliso ea molao oa bosholu ba bana lilemong tsa bocha.

​ 

Melao-kholo

  • Bocheng, ho hlophisoa bocha ha motheo oa kelello ho etsahala ho tsoelang pele ho qala lilemo tse leshome tsa bophelo.
  • Kholiso ea boko ba bongoana e tšoauoa ka ho se lekane pakeng tsa methapo ea methapo le ea meputso e neng e holile pejana, le sistimi ea taolo ea pele ho ea pele. Ho se leka-lekane hona e kanna ea ba neural substrate bakeng sa tloaelo e tloaelehileng ea maikutlo ea bocha, mme e ka khothaletsa boitšoaro bo kotsi.
  • Tloaelo ea bocha ea mantlha ke motheo oa nts'etsopele ea boipuso ho bacha ebile e khothaletsa tokollo ea bona ho tsoa lelapeng la mantlha.
  • Lihormone tsa ho kena bohlankaneng li ama ho ntlafatsoa ka ho khetheha hoa bong bo amanang le botona ba bongoana.
  • Ho hlophisoa bocha ha bongoana ho etsa hore e angoe habonolo ke tšusumetso ea tikoloho, e ntle le e mpe.

lumela hore baa fokola

E fetoletsoe ho tsoa ho Sejeremane sa mantlha ke Ethan Taub, MD

Mongolo o botlaaseng ba leqephe

Khohlano ea polelo ea thahasello

Moprof Konrad o fumane thuto honaria ho tsoa ho likhamphani tsa Medice, Lilly, le Novartis le tšehetso ea lipatlisiso (lithuso tsa lichelete tse kantle) tse tsoang Vifor Pharma Ltd.

Bangoli ba bang ba re ha ho na khohlano ea phaello e teng.

References

1. Crone EA, Dahl RE. Ho utloisisa lilemo tsa bocha e le nako ea ho ikamahanya le maemo a amanang le boiketlo ba sechaba le ho fetoha ha maemo. Tlhahlobo ea tlhaho. Neuroscience. 2012; 13: 636-650. [E fetotsoe]
2. Steinberg L. Ho beha kotsing ea ho ba mocha: ke liphetoho life, 'me hobane'ng? Liphatlalatso tsa New York Academy of Science. 2004; 1021: 51-58. [E fetotsoe]
3. Steinberg L. Ho ba le pono e ntle ka ho teba mabapi le ho beha bacha kotsing. Tlhahlobo ea ntlafatso. 2008; 28: 78-106. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
4. Eaton DK, Kann L, Kinchen S, et al. Ho beha leihlo boits'oaro ba bacha kotsing-United States, 2005. Tlaleho ea beke le beke ea batho ba shoang. Kakaretso ea Phuputso. 2006; 55: 1-108. [E fetotsoe]
5. Bundesamt. Unfälle, Gewalt, Selbstverletzung bei Kindern und Jugendlichen 2010. www.ec-estestatic.de.
6. Mason C. Ntlafatso ea methapo ea kutlo. Koranta ea Neuroscience: koranta ea semmuso ea Mokhatlo oa Neuroscience. 2009; 29: 12735-12747. [E fetotsoe]
7. Giedd JN, Blumenthal J, Jeffries NO, et al. Kholiso ea boko nakong ea bongoana le ea bocha: thuto ea MRI e telele. Neuroscience ea Tlhaho. 1999; 2: 861-863. [E fetotsoe]
8. Huttenlocher PR, Dabholkar AS. Phapang ea tikoloho ea li-synaptogenesis ho cortex ea motho ea motsoala. J Comp Neurol. 1997; 387: 167-178. [E fetotsoe]
9. Perrin JS, Herve PY, Leonard G, et al. Khōlo ea taba e tšoeu bokong ba bocha: karolo ea testosterone le androgen receptor. J Neurosc. 2008; 28: 9519-9524. [E fetotsoe]
10. Yakovlev PA, Lecours IR. Ho potoloha ha boko ho ea bokong. Ka: Minkowski A, mohlophisi. Nts'etsopele ea tikoloho ea boko bongoaneng. Oxford: Blackwell; 1967. maq. 3-70.
11. Murrin LC, Sandersm JD, Bylund DB. Ho bapisa ho fetoloa ha li-system tsa adrenergic le serotonergic neurotransmitter bokong: litlamorao tsa litlamorao tse fapaneng tsa lithethefatsi ho bacha le batho ba baholo. Biochemical Pharmacology. 2007; 73: 1225-1236. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
12. Casey BJ, Jones RM, Hare TA. Boko ba bongoana. Liphatlalatso tsa New York Academy of Science. 2008; 1124: 111-126. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
13. Rakic ​​P, Bourgeois JP, Eckenhoff MF, Zecevic N, Goldman-Rakic ​​PS. Ho hlahisoa ka mokhoa o tšoanang oa li-synapses libakeng tse fapaneng tsa "cortex" ea khale. Mahlale. 1986; 232: 232-235. [E fetotsoe]
14. Singer W. Sebopeho se matla sa marang-rang a sebetsang ka ho hokahanya. Neuron. 2011; 69: 191-193. [E fetotsoe]
15. Lenroot RK, Giedd JN. Kholiso ea boko ho bana le lilemong tsa bocha: lintlha tse tsoang mohopolong oa matla a tlhaho a tlhaho. Tlhahlobo ea Neuroscience le Biobehaivereal. 2006; 30: 718-729. [E fetotsoe]
16. Konrad K. Strukturelle Hirnentwicklung en der Adoleszenz. Ka: Uhlhaas PJ, Konrad K, bahlophisi. Das tezente Gehirn. Stuttgart: Kohlhammer; 2011. maq. 124-138.
17. Huttenlocher PR. Synaptogenesis ho cortex ea motho ea thollo. Ka: Dawson G, Fischer KW, bahlophisi. Boitšoaro ba motho le kelello e ntseng e hola. New York: Guilford Press; 1994.
18. Paus T, Keshavan M, Giedd JN. Hobaneng ha mafu a mangata a kelello a hlaha nakong ea bohlankana? Tlhahlobo ea tlhaho. Neuroscience. 2008; 9: 947-957. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
19. Reiss AL, Abrams MT, Singer HS, Ross JL, Denckla MB. Kholiso ea boko, bong le IQ ho bana. Boithuto ba ho nahana ka volumetric. Boko. 1996; 119: 1763-1774. [E fetotsoe]
20. Blakemore SJ, Choudhury S. Nts'etsopele ea bongoana ea lilemong tsa bocha: litlamorao tsa ts'ebetso ea botsamaisi le kutloisiso ea sechaba. Tlaleho ea Psychology ea Bana le Psychiatry, le Lits'oants'o tsa Allies. 2006; 47: 296-312. [E fetotsoe]
21. Blakemore SJ. Boko ba kelello sechabeng sa bocheng. Tlhahlobo ea tlhaho. Neuroscience. 2008; 9: 267-277. [E fetotsoe]
22. Casey BJ, Duhoux S, Cohen MM. Nako ea bocha: phetisetso, phetoho le phetolelo li amana kae le eona? Neuron. 2010; 67: 749-760. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
23. Galvan A, Hare TA, Parra CE, et al. Pejana nts'etsopele ea maqhubu a amanang le orbitofrontal cortex e ka beha boitšoaro bo ka behang kotsing ho batjha. J Neurosc. 2006; 26: 6885-6892. [E fetotsoe]
24. Galvan A, Hare T, Voss H, Glover G, Casey BJ. Ho nka likotsi le boko ba bongoana: ke mang ea kotsing? Saense ea Ntšetso-pele. 2007; 10: F8-F14. [E fetotsoe]
25. Liston C, Watts R, Tottenham N, et al. Frontostriatal Microstform e hlophisa ho hira ea taolo e sebetsang hantle. Cerebral Cortex. 2006; 16: 553-560. [E fetotsoe]
26. Nagy Z, Westerberg H, Klingberg T. Phallo ea litaba tse tšoeu e amana le nts'etsopele ea mesebetsi ea kelello nakong ea bongoana. Tlaleho ea Curitive Neuroscience. 2004; 16: 1227-1233. [E fetotsoe]
27. Whittle S, Yap MB, Yucel M, et al. Meqolo ea pele le ea li-amygdala li amana le boits'oaro bo amanang le bacha nakong ea puisano ea motsoali le ngoana. Ts'ebetso ea Setsi sa Naha sa Mahlale sa United States of America. 2008; 105: 3652-3657. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
28. Uhlhaas PJ, Roux F, Singer W, Haenschel C, Sireteanu R, Rodriguez E. Nts'etsopele ea neural synchrony e bonts'a ho fetoloa hoa morao-rao le phetisetso ea li-network tsa tšebetso ho batho. Ts'ebetso ea Setsi sa Naha sa Mahlale sa United States of America. 2009; 106: 9866-9871. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
29. Casey BJ, Getz S, Galvan A. Boko ba bongoana. Tlhahlobo ea ntlafatso. 2008; 28: 62-77. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
30. Geier CF, Terwilliger R, Teslovich T, Velanova K, Luna B. Ho ts'oaroa ha ts'ebetso ea meputso le tšusumetso ea taolo ea thibelo bocheng. Cerebral Cortex. 2010; 20: 1613-1629. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
31. van Leijenhorst L, Zanolie K, Van Meel CS, Westenberg PM, Rombouts SA, Crone EA. Ke eng e susumetsang mocha? Libaka tsa methapo e hohelang kutloelo-bohloko ea moputso nakong ea bocha. Cerebral Cortex. 2010; 20: 61-69. [E fetotsoe]
32. Chein J, Albert D, O'Brien L, Uckert K, Steinberg L. Lithaka li eketsa kotsi ea ho kena bohlankaneng ka ho matlafatsa ketsahalo tsamaisong ea moputso ea boko. Saense ea Ntšetso-pele. 2011; 14: F1-F10. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
33. Ts'usumetso ea Gardner M, Steinberg L. Tšusumetso ea lithaka mabapi le ho beha likotsi, ho khetha likotsi, le ho etsa liqeto tse kotsi lilemong tsa bocha le ho ba motho e moholo: thuto ea liteko. Psychology ea Nts'etsopele. 2005; 41: 625-635. [E fetotsoe]
34. Romer D. Ho fokotsa kotsi ea mocha: ho mokhoa o kopaneng oa 2003. Liketekete tsa Oaks: Lingoloa tsa Sage. 2003
35. Spear LP. Boko ba bongoana le liponahatso tse amanang le lilemo tsa bocha. Tlhahlobo ea Neuroscience le Biology. 2000; 24 (4): 417-463. [E fetotsoe]
36. Sisk CL, Foster DL. Motheo oa neural oa ho kena bohlankaneng le boroetsaneng. Neuroscience ea Tlhaho. 2004; 7: 1040-1047. [E fetotsoe]
37. Naninck EF, Lucassen PJ, Bakker J. Liphapang tsa botona le botšehali ho tsa bohlankana: na lihormone tsa thobalano li khethile ho ba kotsing? Tlaleho ea Neuroendocrinology. 2011; 23: 383-392. [E fetotsoe]
38. Schneider M. Puberty joalo ka nako ea nts'etsopele e tlokotsing ka ho fetisisa bakeng sa litlamorao tsa ho pepesetsoa hoa batho ba bang. Biology ea Tlatsetso. 2008; 13: 253-263. [E fetotsoe]
39. Bühler A. Risikoverhalten ho der Jugend. Ka: Uhlhaas PJ, Konrad K, bahlophisi. Strukturelle Hirnentwicklung en der Adoleszenz. Stuttgart: Kohlhammer; 2011. maq. 189-205.
40. Liu X, Somel M, Tang L, et al. Keketseho ea nts'etsopele ea cortical synaptic e khetholla batho ho lichimpanzi le li-macaque. Patlisiso ea genome. 2012; 22: 611-622. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
e1. Hashimoto T, Nguyen QL, Rotaru D, et al. Li-trajectories tse ntlafalitsoeng tse ntlafalitsoeng tsa GABAA receptor alpha1 le polelo ea subunit ea alpha2 ho prortal preortal cortex. Tlholeho ea kelello. 2009; 65: 1015-1023. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
e2. Wahlstrom D, Collins P, White T, Luciana M. Liphetoho tsa nts'etsopele ea li-dopamine neurotransmission bongoaneng: litlamorao tsa boits'oaro le litaba tse hlahlobong. Boko le Kelello. 2010; 72: 146-159. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
e3. Sowell ER, Thompson PM, Leonard CM, Welcome SE, Kan E, Toga AW. 'Mapa o telele oa bokete ba cortical le kholo ea boko ho bana ba tloaelehileng. Koranta ea Neuroscience: Buka ea semmuso ea Mokhatlo oa Neuroscience. 2004; 24: 8223-8231. [E fetotsoe]
e4. Giedd JN. Bokaholimo ba sebopeho sa kelello sa bongoana. Liphatlalatso tsa New York Academy of Science. 2004; 1021: 77-85. [E fetotsoe]
e5. Gogtay N, Giedd JN, Lusk L, et al. 'Mapa o matla oa ntlafatso ea motho nakong ea bongoana ho fihlela e le motho e moholo. Ts'ebetso ea Setsi sa Naha sa Mahlale sa United States of America. 2004; 101: 8174-8179. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
e6. Durston S, Davidson MC, Tottenham N, et al. Fetoha ho tloha ferekanya ho isa tšebetsong tšebetso ea cortical ka kholo. Saense ea ntšetso-pele. 2006; 9: 1-8. [E fetotsoe]
e7. Somerville LH, Jones RM, Casey BJ. Nako ea phetoho: Litloaelo tsa boits'oaro le boits'oaro ba tlhaho ea bongoana bakeng sa takatso ea bocha le litakatso tse fapaneng tsa tikoloho. Boko le kelello. 2010; 72: 124-133. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
e8. Sisk CL, Zehr JL. Lihormone tsa "Pubertal" li hlophisa kelello le boits'oaro ba mocha. Frontiers ho Neuroendocrinology. 2005; 26: 163-174. [E fetotsoe]
e9. Lampert T, Thamm M. Tabak-, Alkohol- und Drogenkonsum von Jugendlichen ho la Deutschland. Ergebnisse des Kinder- und Jugendgesundheitssurveys (KiGGS) Bundesgesundheitsblatt- Gesundheitsforschung - Gesundheitsschutz. 2007; 50: 600-608. [E fetotsoe]
e10. Schlack R, Hölling H. Gewalterfahrungen von Kindern le Jugendlichen im Selbstbericht. Ergebnisse des Kinder- und Jugendgesundheitssurveys (KiGGS) Bundesgesundheitsblatt- Gesundheitsforschung - Gesundheitsschutz. 2007; 50: 819-826. [E fetotsoe]
e11. Ravens-Sieberer U, Wille N, Bettge S, le al. Psychische Gesundheit von Kindern le Jugendlichen naheng ea Deutschland. Ergebnisse aus der BELLA-Studie im Kinder- und Jugendgesundheitssurvey (KiGGS) Bundesgesundheitsblatt - Gesundheitsforschung -Gesundheitsschutz. 2007; 50: 871-878. [E fetotsoe]
e12. Bundeszentrale für gesundheitliche Aufklärung (ed.) Repräsentative Wiederholungsbefragung von 14- bis 17-Jährigen und ihren Eltern. Köln: BZgA; 2006. Bokheleke.
e13. Shell Deutschland Holding (ed.) 15. Jugend 2006. Frankfurt / M .: Fischer; 2006. Shell Jugendstudie.
e14. Lampert T, Mensink G, Romahn N, le al. Körperlich-sportliche Aktivität von Kindern le Jugendlichen ho la Deutschland. Ergebnisse des Kinder- und Jugendgesundheitssurveys (KiGGS) Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 2007a. 50: 634-642. [E fetotsoe]
e15. Lampert T, Sygusch R, Schlack R. Nutzung elektronischer Medien im Jugendalter. Gesundheitsforschung - Gesundheitsschutz; Ergebnisse des Kinder- und Jugendgesundheitssurveys (KiGGS) Bundesgesundheitsblatt- Gesundheitsforschung - Gesundheitsschutz 2007b. 50: 643-652. [E fetotsoe]
e16. Kurth BM. Ergebnisse des Kinder- und Jugendgesundheitssurveys (KiGGS) Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2007; 50: 736-743. [E fetotsoe]

Lingoloa tse tsoang ho li-Deutsches Ärzteblatt International li fanoe ka mokhoa o motle oa Deutscher Arzte-Verlag GmbH