Behav Neurosci. 2019 Aug;133(4):378-384. doi: 10.1037/bne0000313.
Acaba L1, Sidibe D1, Lisa J1, Van der Kloot H1, E bile LE1.
inahaneloang
Boitšoaro bo susumetsoang bo arolelana karolo e tloaelehileng ea ts'ebetso ea mesolimbic dopamine system. Boiphihlelo bo phetoang bo nang le boits'oaro bo susumetsang bo ka baka liphetoho tse telele tsa sebopeho sa li-nucleus accumbens (NAc). Lisebelisoa tsa limolek'hule tse tlasa polasetiki ena e itšetlehileng ka boiphihlelo ho NAc li hlalositsoe hantle boiphihlelo bo latelang bo nang le lithethefatsi tsa tlhekefetso. Haholo-holo, ente e reng Delta FosB (ΔFosB) ke molaoli oa bohlokoa oa neuroplasticity e amanang le lithethefatsi. Boithuto bo fokolang bo hlokometse mekhoa ea limolek'hule e thehiloeng ho ts'ebetso ea ts'epo ea polasetiki ho NAc e latelang boits'oaro bo khothalletsoang, empa lipatlisiso tse fetileng li bontšitse hore boiphihlelo ba thobalano bo eketsa ho bokella ha ΔFosB ho NAc ea li-hamsters tsa basali le likhoto tsa banna. Boitšoaro ba thobalano bo ikhethile har'a boits'oaro bo susumetsang ka hore polelo ea boitšoaro e fapana haholo lipakeng tsa banna le basali ba mofuta o le mong. Leha ho le joalo, papiso e lekantsoeng ea osFosB kamora boiphihlelo ba thobalano ho banna le basali ba mofuta o le mong ha e e-so ka e etsoa. Ka hona re sebelisitse mokhoa oa Bophirimela ho leka hypotase ea hore boiphihlelo ba thobalano bo eketsa ΔFosB ho li-hamsters tsa banna le tsa basali tsa Syria tse latelang boiphihlelo bo pheta-phetang ba thobalano. Re fumane hore boiphihlelo ba thobalano bo eketsa haholo protheine ea ΔFosB ho li-hamsters tsa banna le tsa basali tsa Syria. Ho feta moo, liprotheine tsa ΔFosB li ne li sa fapana pakeng tsa ba batona le ba batšehali kamora boiphihlelo ba thobalano. Ho khahlisang, boiphihlelo ba khafetsa ba ho etsa thobalano bo lebisitse feela ho ntlafatseng katleho e kholo li-hamsters tsa basali; bokopa ba banna ha boa ka ba ntlafala ka boiphihlelo bo pheta-pheto. Ka bobeli, tlhaiso-leseling ena e bonts'a hore ΔFosB e eketseha kamora moputso oa thobalano ho banna le ba batšehali empa e kanna ea senoloa ho tloha boits'oarong ba boits'oaro ho banna. (PsycINFO Database Record (c) 2019 APA, litokelo tsohle li sirelelitsoe).
PMID: 30869949
DOI: 10.1037 / bne0000313
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