Behav Neurosci. 2019 Mar 14. Doi: 10.1037 / bne0000313.
Acaba L1, Sidibe D1, Lisa J1, Van der Kloot H1, E bile LE1.
inahaneloang
Boitšoaro bo susumetsoang bo arolelana karolo e tloaelehileng ea ts'ebetso ea mesolimbic dopamine system. Boiphihlelo bo phetoang bo nang le boits'oaro bo susumetsang bo ka baka liphetoho tse telele tsa sebopeho sa li-nucleus accumbens (NAc). Lisebelisoa tsa limolek'hule tse tlasa polasetiki ena e itšetlehileng ka boiphihlelo ho NAc li hlalositsoe hantle boiphihlelo bo latelang bo nang le lithethefatsi tsa tlhekefetso. Haholo-holo, ente ea taba ea khatiso Delta FosB (ΔFosB) ke molaoli oa bohlokoa oa neuroplasticity e amanang le lithethefatsi. Boithuto bo fokolang bo hlokometse mekhoa ea limolek'hule e thehiloeng holim'a boiphihlelo ba polasetiki ho NAc ho latela boits'oaro bo khothalletsoang ka tlhaho, empa lipatlisiso tse fetileng li bontšitse hore boiphihlelo ba thobalano bo eketsa ho bokella ha ΔFosB ho NAc ea li-hamsters tsa basali le likhoto tsa banna.
Boitšoaro ba botona le botšehali bo ikhethile har'a boitšoaro bo susumetsoang hobane polelo ea boitšoaro e fapana haholo lipakeng tsa banna le basali ba mofuta o le mong. Leha ho le joalo, papiso e lekantsoeng ea ΔFosB kamora boiphihlelo ba thobalano ho banna le basali ba mofuta o le mong ha e e-so ka e etsoa. Ka hona, re sebelisitse mokhoa oa Bophirimela ho leka tlhahlobo ea maikutlo hore boiphihlelo ba thobalano bo eketsa ΔFosB ho li-hamsters tsa banna le tsa basali tsa Syria ka mor'a boiphihlelo bo pheta-pheto ba thobalano. Re fumane hore boiphihlelo ba thobalano bo eketsa haholo protheine ea ΔFosB ho li-hamsters tsa banna le tsa basali tsa Syria. Ho feta moo, maemo a liprotheine tsa ΔFosB a ne a sa fapana lipakeng tsa banna le basali ka mor'a boiphihlelo ba thobalano. Ho khahlisang, boiphihlelo ba khafetsa ba ho etsa thobalano bo lebisitse feela ho ntlafatseng katleho e kholo li-hamsters tsa basali; bokopa ba banna ha boa ka ba ntlafala ka boiphihlelo bo pheta-pheto. Ka bobeli, tlhaiso-leseling ena e bonts'a hore ΔFosB e eketseha kamora moputso oa thobalano ho banna le ba batšehali empa e kanna ea senoloa ho tloha boits'oarong ba boits'oaro ho banna.
PMID: 30869949
DOI: 10.1037 / bne0000313
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