Nat Neurosci. 2006 Feb; 9 (2): 205-11. Epub 2006 Jan 15.
Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ.
mohloli o moholo
Lefapha la Psychiatry le Setsi sa Basic Neuroscience, Univesithi ea Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9070, USA.
inahaneloang
The transaction factor DeltaFosB e kenyellelitsoe ho nucleus accumbens (NAc) le dorsal striatum ke tsamaiso e pheta-pheto ea lithethefatsi tsa tlhekefetso. Mona, re fuputse karolo ea DeltaFosB ho NAc likarabo tsa boitšoaro ho li-opiates. Re fihletse ts'oaetso e fetelletseng ea DeltaFosB ka ho sebelisa mohala oa panya ea bitransgenic e hlalosang hantle protheine ho NAc le dorsal striatum le ka ho sebelisa liphatsa tsa lefutso tse amanang le vaerase ho hlahisa protheine ka kotloloho ho NAc.
DeltaFosB overexpression ho NAc e atolositse kutloisiso ea litoeba ho litlamorao tse thabisang tsa morphine mme ea lebisa ho ts'epahalong e matla ea mmele, empa hape ea fokotsa kutloisiso ea bona litlamorao tsa analgesic tsa morphine mme ea lebisa nts'etsopele ea mamello ea analgesic.
Opynid peptide dynorphin e ne e bonahala e le ntho e le 'ngoe eo DeltaFosB e hlahisitseng mofuta ona oa boitšoaro ka eona.
TKa kakaretso, liteko tsena li bonts'itse hore DeltaFosB ea NAc, karolo e 'ngoe ka phetetso ea polelo ea dynorphin, e arola likarolo tse kholo tsa bokhoba ba opiate.
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