Behav Brain Res. 2015 Dec 27. pii: S0166-4328(15)30344-2. doi: 10.1016/j.bbr.2015.12.035.
Phillips D1, Choleris E1, Ervin KS1, Fureix C2, Harper L3, Reynolds K4, Ke Niel L5, Mason GJ6.
inahaneloang
Boitšoaro ba stereotypic (SB) bo hlaha litsietsing tse itseng tsa batho (mohlala, autism), 'me liphoofolo li tšoaroa ka lintho tse khothatsang kapa tse holisitsoeng maemong a futsanehileng, ho kenyelletsa le litoeba tsa laboratori likhetleng tse tloaelehileng.
Dysfunctional cortico-basal ganglia pathways e kentsoe ts'ebetsong mehlala ena, empa bakeng sa mefuta e khothalletsoang ea cage ea SB, likarolo tse amanang le ts'ebetso ea ventral le dorsal striatum ha li e-so utloisisoe ka botlalo.
Mona, re sebelisitse li-immunohistochemical stain of FosB le ΔFosB ho lekola ts'ebetso ea nako e telele kahare ho li-nucleus accumbens le caudate-putamen ea C57BL / 6 litoeba. E ahile matlong a tloaelehileng a laboratori, litoeba tsena li ithaopetse ho theola mekhahlelo e mengata ea tsela, bar-mouthing le mefuta e meng ea SB (e sebelisa 0% ho fetisa 50% ea likhakanyo tsa nako ea tsona tse sebetsang.
Litoeba tse kholo haholo tsa stereotypic li bonts'itse mosebetsi o phahameng ka ho fetisisa oa FosB / ΔFosB ho li-nucleus accumbens. Ha ho mekhoa e joalo e etsahetseng ho caudate-putamen.
Sage e kenyellelitsoeng ke litoeba tse tloaelehileng tse nang le matlo ka mokhoa ona e kenyelletsa tšebetso e phahameng kahare ho terri striatum, e fana ka maikutlo aetieti e haufi le papali ea chelete ea ho becha, ho ja le ho batla lithethefatsi ho fapana le ho ts'oara mofuta oa khale oa amphetamine le boits'oaro bo bong bo susumetsoang ke motor loop over-activation.
LINKOTSO: Boitšoaro ba stereotypic; boitšoaro bo sa tloaelehang ba ho pheta-pheta; caudate-putamen; li-nucleus accumbens; stereotypy; striatum; lebaka la mongolo; ΔFosB
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