Neuropsychopharmacology. 2013 Sep 26. Doi: 10.1038 / npp.2013.255.
Dietz DM, Kennethy PJ, Letsatsi H, Maze I, Gancarz AM, Vialou V, Koo J, Mouzon E, Ghose S, Tamminga CA, Nestler EJ.
mohloli o moholo
1]
Fishberg Lefapha la Neuroscience le Fryman Brain Institute, Icahn
Sekolo sa Bongaka Mount Mount, Sebaka se le seng sa Gustave L. Levy, New York,
NY, USA [2] Lefapha la Pharmacology le Toxicology le Setsi ho
Likhoele, Univesithing Buffalo, Buffalo, New York, USA.
inahaneloang
ΔFosB, sehlahisoa sa mofuta oa FosB, e kenngoa kahare ho cortex ea pele (PFC) ka ho pepesetsoa makhetlo a mangata a susumetsang a kenyelletsang lithethefatsi tsa antipsychotic tse kang haloperidol. Leha ho le joalo, litlamorao tse sebetsang tsa polelo ea expressionFosB e latelang kalafo ea antipsychotic ha e so fumanoe. Mona, re ile ra lekola hore na ΔFosB ho kenella ka haloperidol e lumellana le litlamorao tse mpe kapa katleho e amanang le tleleniki ea kalafo ea antipsychotic. Re bontša hore batho ba nang le schizophrenia ba neng ba kopantsoe le lithethefatsi tsa antipsychotic ka nako ea bona ea lefu ba ne ba eketsa litekanyetso tsa BFosB ho PFC, e leng phello e phetoang ho likhoto tse tšoaroang nako e telele le haloperidol. Ka lehlakoreng le leng, batho ba nang le lefu la kelello ba neng ba se na meriana ha baa ka ba bontša phello ena. FosB ho PFC ea litoeba e kentse liphokotso tsa kelello joalo ka ha e lekantsoe ka thibelo ea thibelo, likarabo tse qalang tsa ts'ebetso ea PPI, le boits'oaro bo eketsang bo ts'oaroang ba MK-801. Ka bobeli, liphetho tsena li fana ka maikutlo a hore? Ho kenngoa ha FosB ho PFC ka kalafo ea antipsychotic ho kenya letsoho litlamorao tse mpe tsa lithethefatsi tsena eseng lits'ebetsong tsa bona tsa kalafo .Neuropsychopharmacology e amohetse tlhahlobo ea pele ea sehlooho inthaneteng, 26 September 2013. Doi: 10.1038 / npp.2013.255.
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