Eur J Neurosci. 2016 Feb 1. Doi: 10.1111 / ejn.13193.
Herrera JJ1, Fedynska S2, KAHAM PR1, Wman T1, Clark PJ1, Grey N2, Loetz E2, Campeau S3,4, Fleshner M1,4, Greenwood BN1,4.
inahaneloang
Li-circuits tsa meputso ea bongo li na le bohlokoa ho mafu a kelello a amanang le khatello ea maikutlo. Ho ikoetlisa ho fokotsa boemo ba khatello ea maikutlo bo amanang le khatello ea maikutlo, empa karolo ea meputso ea boikoetliso khahlanong le khatello ea maikutlo ha e tsejoe. Ho imeloa kelellong ho bakoang ke khatello ea maikutlo ha hoa ikemela ka ho ikoetlisa; mabili ka bobeli a ikemiselitseng le a qobelloang a sireletsa likhoto khahlanong le matšoenyeho le khatello ea maikutlo joalo ka litlamorao tsa khatello ea maikutlo. Ho ikoetlisa ka boithatelo ke moputso oa tlhaho, empa hore na litoeba li fumana lebili le qobelloang le ntse le putsa ha ho tsejoe. Ntle le moo, monehelo oa dopamine (DA) le mekotla ea meputso ea litheko ha e tšoantšisoe hantle.
Batho ba baholo, likhoto tse tona li ne li abeloa mabili a notletsoeng, ho matha ka boithatelo (VR), kapa lihlopha tse qobelloang tsa ho matha (FR). Likhoto tsa FR li ile tsa qobelloa ho matha ka mokhoa o ts'oanang le boits'oaro ba likhoto tsa tlhaho.
Ka bobeli VR le FR ba ekelitse letšoao le amanang le moputso plasticFosB mabapi le dorsal striatum (DS) le li-nucleus accumbens (NAc), le ts'ebetso e eketsehang ea li-neurons tsa DA sebakeng sa morao sa ventral tegmental tegmental (VTA), joalo ka ha ho senotsoe ke immunohistochemistry bakeng sa tyrosine hydroxylase ( TH) le pCREB.
Ka bobeli likhoto tsa VR le FR li ntlafalitse mokhoa oa boikhethelo (CPP) lehlakoreng la phaposi ea CPP e khabisitsoeng ka boikoetliso.
Ho pepeseha hape lehlakoreng la ho ikoetlisa ka kamoreng ea CPP ho fumaneng boemo bo eketsehile ka cfos mRNA ka kotloloho tseleng ea methapo (dynorphin-positive) ho DS le NAc ka bobeli ho VR le FR rats, le ho li-neurons tsa TH tse ntle ho latela VTA ea morao-rao ea likhoto tsa VR feela.
Liphetho li fana ka maikutlo a hore litlamorao tse matlafatsang tsa boikoetliso ha li ikemisetse ho ikatisa ebile li fana ka leseli ho DA le lipotoloho tse sebetsang tse amanang le moputso oa boikoetliso le khatello ea maikutlo e bakoang ke khatello ea maikutlo.
LINKOTSO: Dopamine; liphatsa tsa lefutso tsa pele; rat; striatum; tikoloho e khelohileng ea moea
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