Biol Psychiatry. 2014 Jul 15. pii: S0006-3223 (14) 00506-X. Doi: 10.1016 / j.biopsych.2014.07.007.
Engeln M1, Motsoako oa Bastide MF1, Tomé E1, Dehay B1, Bourdex M1, Doudnikoff E1, Li Q2, Kakaretso ea CE1, Boué-Grabot E1, Pisani A.3, Bezard E1, Fernagut PO4.
inahaneloang
LITLHAHISO:
OsBFosB ke lets'oao la "L-dopa-indased dyskinesia" (LID), e leng phello e ke keng ea qojoa ea ho holofatsa lefu la Parkinson L-dopa kalafo ea nako e telele. Leha ho le joalo, kamano lipakeng tsa tšebetso ea motlakase ea FosB / ΔFosB-e hlalosang li-neuron le ponahatso ea LID ha e tsejoe.
LITLHAHISO:
Re sebelisitse mokhoa oa Daun02 prodrug-inactivation o amanang le polelo ea lentiviral ea ß-galactosidase e tlasa taolo ea mothetsi oa FosB ho fuputsa kamano ea lisosa lipakeng tsa tšebetso ea FosB / -FosB-e hlalosang methapo ea kutlo le matla a dyskinesia mefuteng ea likhoto le litšoene ea lefu la Parkinson le sekoaelo. Lirekoto tsa sele e felletseng tsa li-spiny neurons tse mahareng (MSNs) li ile tsa etsoa ho lekola litlamorao tsa Daun02 le daunorubicin mabapi le thabo ea methapo ea kutlo.
LIKOTSO:
Re qala re bonts'a hore daunorubicin, sehlahisoa se sebetsang sa metabolism ea Daun02 ke ß-galactosidase, se fokotsa ts'ebetso ea li-MSNs ka mela ea likelello tsa rat le hore Daun02 e fokotsa haholo thabo ea litso tsa mantlha tsa MSN tse hlalosang ß-galactosidase holim'a D1 dopamine receptor. Ka mor'a moo re bonts'a hore ts'ebetso e khethollang le e feto-fetohang ea FosB / ΔFosB e bontšang striatal neurons e nang le Daun02 e fokotsa botebo ba LID ha e ntse e ntlafatsa ts'ebetso e ntle ea L-dopa.
CONCLUSIONS:
Liphetho tsena li tiisa hore ho bokellana ha FosB / ΔFosB qetellong ho hlahisa thepa e fetotsoeng ea "neuronal" e sebelisang li-circuits tse mpe tse isang feela ho LID empa le karabelo e sa hlakang ea L-dopa. Liphumano tsena li senola hape hore dyskinesia e lebisang ho eona e ka fumaneha ntle le ho fokotsa thepa ea antiparkinsonia ea L-dopa ha e thibela ka ho khetheha li-neuron tsa FosB / ΔFosB.
Copyright © 2014 Mokhatlo oa Biology Psychiatry. E phatlalalitsoe ke Elsevier Inc. Litokelo tsohle li sirelelitsoe.
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