Am J Juse drug Usecohol. 2019; 45 (1): 84-89. Doi: 10.1080 / 00952990.2018.1529182.
Sadat-Shirazi MS1,2, Babhadi-Ashar N1, Khalifeh S3, Mahboubi S2, Ahmadian-Moghaddam H1, Zarrindast MR1,4,5.
inahaneloang
LITLHAHISO:
Ntle le phello ea analgesic ea tramadol, ho pepesetsoa nako e telele ho tramadol ho ka baka liphetoho tse feto-fetohang ka hona ho lebisang ho ts'epahallong le mamellong. Tramadol e etsa phello ea eona ka µ-opioid receptor (MOR). Leha ho le joalo, tramadol e na le lipheo tse ling tse joalo ka bajari ba serotonin le ba epinephrine.
MORERO:
CREB le ΔFosB ke lintlha tse hatisang, tse amehang litabeng tsa boitšoaro bo bobe tlasa tlhekefetso ea lithethefatsi. Thutong ena, ho ile ha ithutoa litlamorao tsa kalafo ea kalafo e mpe le e sa foleng ea "tramadol" maemong a MOR, ΔFosB le CREB.
LITLHAHISO:
Bakeng sa sena, ho ile ha sebelisoa likhoto tsa banna tsa Wistar tse 36. Liphoofolo li arotsoe ka lihlopha tse peli tse kholo. Palo ea liphoofolo tse 18 li fumane tramadol (0, 5, le 10 mg / kg) hantle 'me liphoofolo tse 18 li fumane litekanyo tse tšoanang matsatsing a 14 a latelang. Hora e le 'ngoe kamora ente ea ho qetela, NAC le PFC li ile tsa aroloa' me tsa bolokoa ho -80 ° C ka naetrojene ea metsi. Ho sebelisoa mokhoa oa bophirima oa bophirima, maemo a MOR, ΔFosB le p-CREB a ile a hlahlojoa.
LIKOTSO:
Ho NAC, ho pepeseha ka mokhoa o hlobaetsang oa tramadol ho eketsa maemo a MOR le p-CREB. Ho feta moo, tsamaiso ea tramadol e sa feleng sebakeng sena e baka maemo a phahameng a MOR, ΔFosB le p-CREB ha a bapisoa le likhoto tse tšoaroang ka letsoai. Maemo a MOR le p-CREB ho PFC a eketsehile ponts'ong e matla le e sa foleng ea tramadol. Hape, maemo a ΔFosB a eketsehile kamora ho latela ts'ebetso ea tramadol e sa feleng. Liphetho li bontšitse hore ho bile le liphetoho tse fetohileng nakong ea ho pepesetsoa lithethefatsi.
QETELLO:
Re ile ra fihlela qeto ea hore CREB le ΔFosB li bapala karolo ea boiketlo ba tramadol. Ho kenyelletsa moo, litekanyo tsa MOR tse eketsehileng nakong ea kalafo ea tramadol li ka ba teng ka lebaka la takatso ea receptor.
LITLHAKISO TSE KHOLO: CREB; Tramadol; li-nucleus accumbens; preortal cortex; Receptor ea µ-opioid; ΔFosB
PMID: 30632799
MOTHE: 10.1080 / 00952990.2018.1529182
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