Neuropsychopharmacology. 2016 Aug 12. Doi: 10.1038 / npp.2016.151.
Qeto ea HK1,2, Namboodiri VM2,3, Gao W.4,5, McHenry JA2, Jennings JH1,2, Lee SH5,6, Kantak PA2, Kao YC5,6, Das M5,6, E ngotsoe IB7, Deisseroth K8, Shih YY1,5,6,9, GD ea Stuber1,2,3.
inahaneloang
Maemo a 'maloa a neuropsychiatric, joalo ka ho lemalla le lefu la kelello le ka hlaha ka karolo e itseng mesebetsing ea dysaminal ea sebakeng sa dopaminergic (THVTA) li-neuron, hammoho le ho tsoa ho maladaptation e eketsehileng lefats'eng la ts'ebetso ea methapo ea kutlo.
Leha ho le joalo, hore na THVTA Ts'ebetso e ama ts'ebetso e kholo-kholo ea boko e lula e sa tsejoe. Mona, re khetha ka mokhoa o khethiloeng THVTA li-neurons tse liphatseng tsa transgenic le liphetoho tse lekantsoeng tse hlahisang ts'ebetso ea boko bohle bo sebelisa ts'usumetso ea ts'ebetso ea matla a matla a matla a fono (fMRI). Re sebelisa mokhoa o tloaelehileng oa tlhahlobo ea ("general") ea tlhahlobo e akaretsang, liphetho tsa rona li bonts'a ts'usumetso ea khetha ea optogenetic ea THVTA li-neurons tse ntlafalitseng bophahamo ba mali ("li-cV") tsa "" "" libakeng tsa sepheo sa "" dopamine receptor ".
Leha ho le joalo, tlhahlobo ea mantlha ea likarolo tsa mantlha tsa boko (PCA) ea bongoana e senotse hore module ea dopaminergic e kenya likarolo tse ling tse fapaneng kahare bokong, e sa amaneng le liketsahalo tsa tokollo ea dopamine. Ho feta moo, ho rala ka mokhoa o hlakileng oa THVTA ts'ebetso ea neuronal e nang le tšusumetso ea ponelo-leseling ea frequency e itseng e atolositse setšoantšo sa maikutlo a khothalletso eo, eseng feela ka har'a li-cortices tsa somatosensory, empa bokong ka bophara.
Tlintlha tsa hese li fana ka maikutlo a hore modumo ea THVTA Li-neuron li ka ama matla a boko ho libaka tse ngata tse arolelanoang ka mokhoa o ikhethang, esita le tse sa fuoang ho hlakaVTA kenyelletso.
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