Kay M. Tye, Julie J. Mirzabekov, Melissa R. Warden, Emily A. Ferenczi, Hsing-Chen Tsai, Joel Finkelstein, Sung-Yon Kim, Avishek Adhikari, Kimberly R. Thompson, Aaron S. Andalman, Lisa A. Gunaydin, Ilana B. E hlotseng & Karl Deisseroth
Tlhaho (2012) doi: 10.1038 / nature11740
- E amohetse 02 May 2012
Ho tepella maikutlo ho hoholo ho tšoauoa ka matšoao a fapa-fapaneng a fokolisang a kenyang ho hloka tšepo le anhedonia1. Dopamine li-neurons tse amehang moputsong le tšusumetso2, 3, 4, 5, 6, 7, 8, 9 li har'a lipalo tse ngata tsa neural tse boletsoeng hore li nepahetse10, le mekhoa e meng ea kalafo ea meriana e loantšang khatello ea maikutlo, ho kenyelletsa le litlhare le litlhare tse khothatsang tsa boko, li ka susumetsa sistimi e rarahaneng ea dopamine. Ho fihlela hajoale ha ho a ka ha khoneha ho leka hypothesis ena ka kotloloho, esita le mehlaleng ea liphoofolo, kaha mekhoa ea phekolo e teng e sa khone ho tobisa kannete li-dopamine neurons. Mona re fuputse ka kotloloho monehelo oa causal oa "dopamine neurons" o hlalositsoeng ka khatello ea maikutlo ka bongata ka ho fetesisa khatello ea maikutlo, ka ho hokahanya mekhoa ea boits'oaro, ea meriana, ea optogenetic le ea electrophysiological metsong e tsamaeang ka bolokolohi. Re hlokometse hore taolo ea concirectional (inhibition or excitation) ea "midbrain dopamine neurons" e potlakileng le li-modirectionally modulates (induces kapa relieves) matšoao a mangata a ikemetseng a khatello ea maikutlo a bakiloeng ke khatello ea maikutlo e sa foleng. Ka ho hlahloba ts'ebetso ea potoloho ea litlamorao tsena, re hlokometse hore ho haptjoa ha li-optogenetic tsa "dopamine neurons" hantle ho fetola mokhoa o kopantsoeng oa boits'oaro bo amanang le khatello ea maikutlo mokhoeng o ka tlase oa methapo ea methapo e tsamaeang ka bolokolohi, ho fana ka maikutlo a hore lits'ebetso tse amang matšoao a khatello ea maikutlo li ka kenyelletsa liphetoho tsa tlhaho encoding of Ketso ea maoto le matsoho.
;
