Neuropsychopharmacology. 2017 Aug 22. Doi: 10.1038 / npp.2017.183.
Dubol M1,2, Trichard C1,2,3, Leroy C1,2,4, Sandu AL1,2,5, Rahim M6,7, Granger B1,2,8, Tzavara ET1,2,8,9, Karila L1,2,10, Martinot JL1,2, Artige E1,2,11.
inahaneloang
Ts'ebetso ea Dopamine le ts'ebetso ea moputso li hokahane haholo 'me li kenyelletsa libaka tse tloaelehileng tsa boko tse amanang le Nucleus Accumbens, ka har'a tsela ea mesolimbic. Le ha tšebetso ea dopamine le "system" ea "neop" e sebetsa haholo ka har'a mathata a mangata a kelello, ha ho tsejoe haeba liphetoho tse teng tsamaisong ea dopamine li ntse li fapana ka ts'ebetso ea moputso molemong oa bophelo bo botle le mathata ana. Re ile ra hlahloba kamano pakeng tsa ts'ebetso ea dopamine le ts'ebetso ea neural nakong ea tebello ea moputso ho barupeluoa ba mashome a mabeli a metso e supileng ho kenyelletsa le baithaopi ba phetseng hantle le bakuli ba kelello ba nang le lefu la kelello le khatello ea maikutlo kapa ts'ebetso ea koae, re sebelisa Magnetic Resonance Imaging (fMRI) le Positron Emission Tomography (PET) imaging e ngata le mokhoa oa lipalo-palo oa voxel. Ho fumaneha ha Dopamine (DAT) ho ile ha hlahlojoa ka PET le [11C] PE2I e le letšoao la ts'ebetso ea dopamine ea presynaptic, le karabelo e amanang le moputso e ile ea hlahlojoa ho sebelisoa fMRI ka mosebetsi o fetotsoeng oa Monetary Incentive Delay. Ho pholletsa le barupeluoa bohle, ho fumaneha ha DAT ka har'a mpa e amana hantle le karabelo ea neural ho tebello ea moputso ho Li-Numus Accumbens.
Ho feta moo, likamano tsena li ne li bolokiloe sehlopheng se seng le se seng sa kliniki, le ha ho ne ho hlahlojoa lefu la kelello. Ka lekhetlo la pele, khokahano e tobileng lipakeng tsa ho fumaneha ha DAT le tebello ea moputso e fumanoe kahare ho tsela ea mesolimbic ho barupeluoa ba phetseng hantle le ba kelello, mme e fana ka tlhahiso ea hore ho se sebetse ka dopaminergic ke mochini o tloaelehileng o tlasa liphetoho tsa ts'ebetso ea meputso e hlokometsoeng ho bakuli ka mefuta eohle ea tlhahlobo.
Liphumano li ts'ehetsa ts'ebeliso ea mokhoa o shebelletseng litabeng tsa mafu a kelello, joalo ka ha li khothalelitsoe ke morero oa Research Domain Criteria (RDoC) ho khetholla matšoao a neurobiological a dysfunctions tsa mantlha tse tlasana le mafu a kelello.Neuropsychopharmacology e amohetse sengoloa sa pele inthaneteng, 22 August 2017. Doi: 10.1038 / npp.2017.183.
PMID: 28829051
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