Maikutlo: Li-agonists tsa D2 li-receptor li fokotsa ho tšoenyeha
inahaneloang
Ho bapisa karolo ea D2-subtype dopaminergic receptors ka mekhoa ea boits'oaro ho likhoto tsa basali tse sa sebetseng nakong ea maqhubu a ovary le ovariectomized (OVX) likhoto tsa basali, tšusumetso ea taolo e sa foleng ea D2-dopaminergic receptors agonist-quinperole (0.1 mg / kg) le D2-dopaminergic receptors antagonist – sulpiride (10.0 mg / kg) e entiloe ka thoko kapa e kopantsoe le 17beta-es-tradiol (0.5 mcg bakeng sa phoofolo e ngoe le e ngoe) nakong ea matsatsi a 14 ka boemo ba boits'oaro ba likhoto tsa basali tse tsoileng matsoho le tsa ovariectomised (OVX) li ile tsa batlisisoa. Boemo ba matšoenyeho bo ile ba hlahlojoa ka har'a maze e phahameng, boits'oaro ba liphoofolo bo hakantsoe tekong ea naha e bulehileng. Ho ile ha thehoa hore taolo e sa foleng ea sulpiride ho likhoto tse sa tsitsang e hlahisitse boits'oaro ba matšoenyeho maemong a phahameng a kopantseng methating eohle ea potoloho ea mahe a bomme ntle le botumo. Tsamaiso ea Quinperole ho likhoto tse sa tsitsang e ne e na le ketso ea ho tšoenyeha ka boits'oaro boemong bo phahameng ba 'mele ho metestrous, diestrous le proestrous. CTsamaiso ea hronic quinperole e le 'ngoe kapa e kopane le 17beta-estradiol ho likhoto tsa OVX e hlahisitse phello e tšoenyang ea boitšoaro boi matsatsing a holimo le holimo. Ho fapana le hoo, tsamaiso ea sulcolide e le 'ngoe feela ho likhoto tsa OVX e ile ea sitoa ho fetola boemo ba ho tšoenyeha, ha e kopana le 17beta-estradiol phello e tšoenyang ea lithethefatsi tsa hormone e ne e koetsoe ka mokhoa o khahlisang. Ts'ebetsong e bulehileng ea tlhahlobo ea quinperole ho likhoto tsa OVX li ile tsa eketsa ts'ebetso ea locomotor e otlolohileng, boits'oaro ba boits'oaro le boits'oaro. Kahoo, liphetho tse fumanoeng li fana ka maikutlo a karolo ea modulating ea li-receptor tsa D2-subtype dopaminergic methating ea boitšoaro ba ho tšoenyeha ho se lekane ha estrogen.
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