Sehlopha se secha se ka bang teng se potlakisang khatello ea maikutlo
Mphalane 29th, 2013 ho Psychology & Psychiatry
Ho feta 1 ho Maamerika a 10 a nka li-antidepressants, empa meriana ena e ka nka libeke-mme ho bakuli ba bang, likhoeli-pele ba qala ho fokotsa matšoao. Joale, bo-rasaense ba tsoang Univesithing ea Chicago ba hlokometse hore ka mokhoa o ikhethileng, serotonin receptor subtype e etsa litlamorao tse potlakileng tsa litla-morao tsa litoeba, ho supa sehlopha se secha sa kalafo bakeng sa khatello ea maikutlo. Mosebetsi ona o phatlalalitsoe Oct. 29 ho Molecular Psychiatry.
“Bothata bo bong bo boholo kalafong ea khatello ea maikutlo ke ho lieha ho qala ha litlamorao tsa kalafo. Ho bile le tlhoko e kholo ea ho sibolla lithethefatsi tse sebetsang ka potlako, ”ho boletse Stephanie Dulawa, PhD, motlatsi oa moprofesa oa mafu a kelello le boits'oaro ba methapo ea kutlo Univesithing ea Chicago ebile e le sengoli se phahameng sa thuto.
Ho lieha ho qala ha kalafo ea kalafo ea meriana e loantšang likhathatso ho ka ama bakuli haholo, haholo ba nang le lefu le tebileng la khatello ea maikutlo, bao hangata ba fetang likhoeli ba fetoha lipakeng tsa meriana e sa sebetseng. Hajoale, ke lithethefatsi tse peli feela-ketamine le scopolamine-
Ha a batla sehlopha se secha sa kalafo e potlakileng ea tšebetso, Dulawa le sehlopha sa hae ba ile ba leka liteko tsa tlhaho tse neng li kile tsa bontšoa ho hlahisa litlamorao tsa khatello ea maikutlo empa ho ne ho se mohla li kileng tsa ithutoa ka tekanyo ea ho qala. Ba ne ba sheba li-subtypes tse fapaneng tsa li-serotonin receptors, liprotheine tse tlamang balekane bakeng sa serotonin, neurotransmitter e bonts'itsoeng ho laola mohopolo, ho hopola le takatso ea lijo.
Ho li-subtypes tsena, li-receptors tsa serotonin 2C li ile tsa hlahella. Ka ho khetha li-receptor tsena ka litoeba li fokotsehile boits'oaro bo kang matsatsi a mahlano feela ha ho bapisoa le bonyane beke tse peli bakeng sa moriana o thibelang khatello ea maikutlo..
"Re bone litlamorao tsa kalafo tse sebetsang ka potlako mesebetsing e mengata ea boits'oaro kamora hore re fane ka metsoako e thibelang li-receptors tsa serotonin 2C," ho boletse Mark Opal, moithuti ea tsoang sekolong se phahameng Univesithing ea Chicago ebile e le mongoli ea ka sehloohong oa pampiri. "Re qalile litekanyo tsa rona ka matsatsi a mahlano, empa re nahana hore ho na le monyetla oa hore e ka sebetsa kapele ho feta moo."
Li-receptor tsa Serotonin 2C ka tloaelo li thibela ho ntšoa ha dopamine, neurotransmitter e 'ngoe e atisang ho amahanngoa le mohopolo, ho tsoa ho li-neuron tse itseng. Ha 2C e koetsoe, bafuputsi ba lumela, dopamine e eketsehileng e lokolloa ka likarolo tsa boko tse joalo ka cortex ea pele. Sehlopha se boetse se hlokometse ho kenella ha li-biomarkers tse bonts'ang ts'ebetso ea antidepressant.
Ona ke mokhoa oa pele oa tlhaho oa tlhaho o bonts'itseng bokhoni ba ho fokotsa ka potlako matšoao a khatello ea maikutlo ho tloha ketamine le scopolamine, 'me e emela mofuta o mong o sireletsehileng haholo. Li-antidepressants tse ling tsa hona joale 'marakeng li se li amme li-serotonin 2C receptors, leha e se ka boikhethelo, mme Dulawa o lumela hore boemo ba polokeho bo loketse tšebeliso ea batho. Hona joale sehlopha se ntse se etsa lipatlisiso tsa lik'hemik'hale tse loketseng liteko tsa bongaka.
"E 'ngoe ea melemo ea mantlha ea ho sibolloa ha rona ke hore sena ke sepheo se se nang molato ho feta tse ling tse fumanoeng," ho boletse Dulawa.
Tlhahisoleseling e ngoe: "Bahanyetsi ba Serotonin 2C ba baka litlamorao tse potlakileng tsa ho imeloa kelellong," Molecular Psychiatry, 2013.
E fanoe ke University of Chicago Medical Center
“Ho ka ba le sehlopha se secha sa batho ba sebetsanang le ho imeloa kelellong ka potlako.
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