Neural Regen Res. 2014 May 15; 9(10):1079-88. doi: 10.4103/1673-5374.133171.
Liu D, Hu L, Zhang J, Zhang P, Li S.
inahaneloang
Bopaki bo felletseng bo fana ka maikutlo a hore li-nucleus li bokellana, tse kenyelletsoeng mekhoeng ea moputso le bokhoba, li bapala karolo ea pathogeneis ea khatello ea maikutlo le ts'ebetsong ea antidepressants.
Phuputsong e teng hona joale, entraperitoneal ente ea nomifensine, dopamine reuptake inhibitor, e fokolitse boits'oaro bo joalo ba khatello ea maikutlo ho Wistar Kyoto rat rat khethong ea sucrose le litekong tsa ho sesa tse qobelloang. Nomifensine e boetse e fokolitse thabo ea membrane ho li-spiny neurons tse bohareng ba konokono ea li-nucleus bongoaneng oa Wistar Kyoto likoto joalokaha li lekantsoe ke ho rekota hoa motlakase.
Ntle le moo, polelo ea dopamine D2-like receptor mRNA e ne e theotsoe ka mokokotlong oa li-nucleus, striatum le hippocampus tsa bongoana tse tšoaroang ke ngoana Wistar Kyoto. Liphumano tsena tsa liteko li bonts'a hore thibelo e sa senyeheng ea li-neurons tse mahareng tsa mokokotlo, e kopantsoeng le li-receptors tsa dopamine D2-like receptors, e kanna ea kenya letsoho ho thehoeng ha boits'oaro bo kang bo sithabetsang bongoaneng ba Wistar Kyoto, le hore nomifensine e ka fokotsa boits'oaro bo nyenyefatsang ka ho fokotsa thabo ea "membrane" ea spiny neuron.
LINKOTSO:
Li-MSN; Thuso ea NSFC; Likhoto tsa Wistar Kyoto; ho lemala ha boko; khatello ea maikutlo ea bongoana; dopamine D2-li-receptor tse kang; thibelo e nyarosang; ts'ebetso ea methapo; polasetiki ea neural; nchafatso ea tlhaho; neurophysiology; nomifensine; nucleus accumbe
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