Behav Neurosci. 2014 Jun 9. [Epub pele ho khatiso]
Costa VD, Tran VL, Turchi J, BOLOBB.
inahaneloang
Ho batla ho tsebahala ho bolela tloaelo ea batho le liphoofolo ea ho lekola lipale le maemo a sa tloaelehang. Khopolo ea hore dopamine e hlophisa ho batla ka mokhoa o sa tloaelehang e tšehetsoa ke bopaki ba hore li-novel stimuli li thabisa dopamine neurons mme li kenya tšebetsong libaka tsa boko tse amohelang kenyelletso ea dopaminergic. Ntle le moo, dopamine e bonts'oa ho khanna boits'oaro ba lipatlisiso libakeng tsa lipale. Ha ho hlake hore na dopamine e khothaletsa ho batla ho ncha ha e entsoe e le qeto ea ho lekola likhetho tsa lipale le tšebeliso e mpe ea likhetho tse tloaelehileng. Ho leka khopolo-taba ena, re ile ra fana ka liente tsa systemic tsa saline kapa GBR-12909, e khethang dopamine transporter (DAT) inhibitor, ho litšoene le ho lekola boits'oaro ba bona ba ho batla boits'oaro nakong ea mosebetsi oa ho etsa liqeto. Mosebetsi o ne o kenyelletsa likenyelletso tsa pseudorandom tsa likhetho tsa khetho ea lipale. Sena se file litšoene monyetla oa ho lekola likhetho tsa lipale tse ncha kapa ho sebelisa mekhoa e tloahelehileng eo ba seng ba ntse ba e sampile. Re fumane hore thibelo ea DAT e ekelitse litšoene tse khethiloeng bakeng sa likhetho tsa lipale. Moetso oa thuto e matlafatsang (RL) o lumellanang le tlhaiso-leseling e khethiloeng ke litšoene o bonts'itse hore mokhoa o mocha oa ho batla lintho tse ncha kamora ho thibeloa ha DAT o tsamaisitsoe ke keketseho ea boleng ba pele ba litšoene tse abetsoeng likhetho tsa lipale. Leha ho le joalo, ho thibela DAT ha hoa ka ha etsisa sekhahla seo litšoene li ithutileng sona hore na ke lintlha life tse neng li bolela esale pele ka moputso kapa tloaelo ea bona ea ho sebelisa tsebo eo hampe. Lintlha tsena li bonts'a hore dopamine e ntlafatsa boleng bo khannoang ke bocha 'me e fana ka maikutlo a hore mokhoa o feteletseng oa ho batla mokhoa oa ho se ts'oenyehe le oa boitšoaro bo hlephileng o ka bakoa ke keketseho ea dopamine, e bakoang ke ho khutlisoa hape. (PsycINFO Database Record (c) 2014 APA, litokelo tsohle li bolokiloe).
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