Tšebeliso ea Lithethefatsi e Tšepahala. 2015 Sep 1;154:167-73. Doi: 10.1016 / j.drugalcdep.2015.06.039. Epub 2015 Jun 30.
Matuskey D1, Gaiser EC2, Gallezot JD3, Angarita GA4, Pittman B4, Nabulsi N3, Ropchan J3, MaCleod P4, Cosgrove KP2, Ding YS5, Potenza MN6, Carson RE3, Malison RT4.
inahaneloang
LITLHAHISO:
Mosebetsi oa pele ho li-primates tse se nang batho tsa bophelo bo botle mme batho ba bontšitse hore boemo ba boiketlo ba sechaba bo lumellana hantle le dopamine 2 / 3 receptor (D2 / 3R) phumaneho e bontšitsoeng ka radioligands ea antagonist le positron emission tomography (PET). Mosebetsi o mong hape litlalehong tse seng tsa batho o supa hore kamano ena e sitisoa ke tsamaiso ea koae e sa foleng. Patlisiso ena e hlahlobang kamano e pakeng tsa boemo ba sechaba le ho fumaneha ha D2 / 3R ho batho ba phetseng hantle (HH) le batho ba itšetlehileng ka koae (CD) ba sebelisang D3-prefer, agonist radioligand, [(11) C] (+) PHNO.
LITLHAHISO:
Batho ba 16 HH le li-CD tse leshome le metso e tšeletseng ba tlatsitse Barratt Simplified Measure of Social Status (BSMSS) mme ba tlangoa [(11) C] (+) ScNO ea skena ho lekola boko ba tikoloho D2 / 3R e tlamang. Likamano lipakeng tsa BPND le BSMSS li ile tsa hlahlojoa kahare ho sehlopha ka seng.
LIKOTSO:
Ka har'a lihlopha tsa HH le li-CD, mekhatlo e sa lumellaneng pakeng tsa lintlha tsa BSMSS le BPND e ile ea bonoa sebakeng sa substantia nigra / ventral tegmental (SN / VTA) le li-ventral striatum, le bakeng sa sehlopha sa CD feela, amygdala. Kamora ho feto-fetoha ha index ea boima ba 'mele le lilemo, ho hokahana ho fosahetseng ho ile ha lula ho le bohlokoa ho SN / VTA bakeng sa HH le amygdala bakeng sa lithuto tsa CD.
QETELLO:
Lintlha tsena tsa pele tse sebelisang troper ea dopamine agonist tracer, ka lekhetlo la pele, kamano e sa lumellaneng pakeng tsa boemo ba sechaba le phihlello ea D2 / 3R libakeng tsa D3R tse hole le HH le batho ba CD.
Copyright © 2015 Elsevier Ireland Ltd. Litokelo tsohle li sirelelitsoe.
LINKOTSO:
Cocaine; Dopamine; Ho nahana ka PET; Boemo ba sechaba; [(11) C] (+) PHNO
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