Tšebeliso ea Lithethefatsi e Tšepahala. 2016 Feb 12. pii: S0376-8716 (16) 00059-4. Doi: 10.1016 / j.drugalcdep.2016.01.029.
Okita K1, Ghahremani DG2, Morekisi DE3, Robertson CL4, Dean AC2, Mandelkern MA5, London ED6.
inahaneloang
LITLHAHISO:
Batho ka bomong ba sebelisang methamphetamine khafetsa ba bontša bofokoli ba maikutlo le dopaminergic neurochemical. Le ha amygdala e na le karolo ea bohlokoa ts'ebetsong ea maikutlo mme e fumana dopaminergic innervation, ha ho tsejoe ho tseba ka phetiso ea dopamine sebakeng sena e tlatsetsa ho taolo ea maikutlo. Patlisiso ena e ne e rerile ho lekola taolo ea maikutlo ho lithuto tse kopaneng le litekanyetso tsa DSM-IV tsa ts'ehetso ea methamphetamine, le ho leka kamano pakeng tsa litlaleho tsa mathata a taolo ea maikutlo le D2-mofuta oa dopamine receptor ho fumaneha ho amygdala.
METHODO:
Lihlooho tse mashome a robong a metso e mene tse sebelisang methamphetamine le 102 li-taolo tse phetseng hantle li phethetse mathata a Emong Regulation Scale (DERS); 33 ea ba neng ba sebelisa methamphetamine ba ile ba tlatsa Adiction Severity Index (ASI). Setsi sa lihlopha tsa 27 methamphetamine-group le li-20 li-group-control lihlopha li phethile positron emission tomography le [18F] fallypride ea ho qobella ho fumaneha hoa amygdala D2-mofuta dopamine receptor, e lekantsoeng e le bokhoni bo tlamang (BPND).
LIKOTSO:
Sehlopha sa methamphetamine se fumane lintlha tse phahameng ho feta sehlopha se laolang palo e felletseng ea DERS (p <0.001), mme lintlha tsohle tsa DERS li hokahane hantle le Lenaneo la Lithethefatsi tse Kopaneng ho ASI (p = 0.02) sehlopheng sa methamphetamine. Palo eohle ea DERS e ne e tsamaellane hantle le amygdala BPND ka lihlopha tsena ka bobeli le sehlopha se kopaneng sa bankakarolo (se kopaneng: r = 0.331, p = 0.02), mme lihlopha li ne li sa fapana kamanong ena.
QETELLO:
Liphumano tsena li totobatsa mathata ka taolo ea maikutlo e hokahantsoeng le tšebeliso ea methamphetamine, mohlomong e kenya letsoho mathateng a boits'oaro a motho ka mong. Ba boetse ba fana ka maikutlo a hore li-dopamine li-receptor tsa D2 mofuta oa amygdala li kenya letsoho taolong ea maikutlo maemong a mabeli a phetseng hantle le methamphetamine.
LINKOTSO:
Amygdala; Dopamine; Tekanyetso ea maikutlo Methamphetamine; PET; [(18) F] Fallypride
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