Nako ea mokokotlo. 1997 May; 5 (4 Pt 1): 251-60.
Larisch R, Klimke A, Vosberg H, Löffler S, Gaebel W, Müller-Gärtner HW.
mohloli o moholo
Tleliniki ea Bongaka ba Nyutlelie, Univesithi ea Düsseldorf, Jeremane.
inahaneloang
Sistimi ea dopaminergic ke mokhethoa oa methapo ea kutlo ea methapo eo ho nahanoang hore e kentse letsoho ho pathogenesis ea khatello ea maikutlo. Phuputso ena e shebana le bothata hore na matla a ho imeloa kelellong a serotonin reuptake inhibition a amana joang le liphetoho tsamaisong ea cerebral dopaminergic. Cerebral dopamine-D2 receptors li ne li khetholloa ho bakuli ba 13 ba nang le khatello ea maikutlo e kholo ba sebelisa mohanyetsi oa li-receptor-dopamine2 iodobenzamide le single photon emission tomography. Ho tlamella li-receptor tsa Dopamine ho ile ha hlahlojoa habeli, pele le nakong ea ts'ireletso ea serotonin reuptake. Keketseho ea tlamo ea receptor ea dopamine-D2 nakong ea serotonin reuptake inhibition e fumanoe ho striatum le anterior cingulate gyrus ho ba arabelang kalafo, empa eseng ho bao e seng bangoli. Keketseho ea tlamo ea receptor ea dopamine-D2 e hokahane haholo le ho fola ha kalafo ho tsoa ho khatello ea maikutlo joalo ka ha ho lekantsoe le sekala sa khatello ea maikutlo sa Hamilton (r = 0.59 bakeng sa striatum ea letsohong le letona le le letšehali ka ho latellana, P <0.05; r = 0.79 bakeng sa anterior cingate gyrus, P <0.05 kamora Khalemelo ea Bonferroni). Likamano tse ts'oanang hantle li ile tsa bonoa ho gyrus ea pele ho moo, gyrus e ka pele e ka pele, gyrus e ka tlase e ka pele, le karolo e ka pele ea gyrus ea opercular, empa likamano tsena li ile tsa hloleha ho fihlella bohlokoa ba lipalo kamora khalemelo bakeng sa litlamorao tsa liteko tse ngata. Ha ho likamano tse joalo tse fumanoeng ho gyrus e ka pele e ka pele, gyrus rectus, gyrus e phahameng ea parietal, kapa gyrus e phahameng ea nakoana. Lintlha li matlafatsa mohopolo oa hore striatum le anterior cingulate gyrus li kentse letsoho taolong ea maikutlo. Li-receptor tsa Dopamine-D2 e ka ba karolo ea mantlha sebakeng sena.
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