Mol Psychiatry. 2013 May 28. doi: 10.1038 / mp.2013.57.
Trifilieff P, Feng B, Urizar E, Winiger V, Ward RD, Taylor KM, Martinez D, Moore H, Balsam PD, Simpson EH, Javitch JA.
mohloli o moholo
1] Lefapha la Neuroscience, Univesithing ea Columbia, New York, NY, USA [BONYANE] New York State Psychiatric Institute, New York, NY, USA.
inahaneloang
Ho fokotseha ha dopamine D2 receptor (D2R) e tlamang karolong ea striatum ke e 'ngoe ea lintho tse tloaelehileng ka ho fetisisa litabeng tse amanang le ho senyeha ha tšusumetso, ho kopanyelletsa ho nona haholo, ho lemala le ho hlokomoloha bothata ba ho kula. Joalokaha ho ferekanya ha D2R ho bontša phapanyetsano ea ventral-ho akarelletsa le nucleus accumbens (NAc) -e leng lihlopha tse susumetsang, re ile ra batla ho bona hore na ho ka etsahala hore ebe D2R e itšetlehile ka hore ho na le matšoao ho NAC e tla ntlafatsa tšusumetso. Phuputsong ena, re sebelisitse leano la likokoana-hloko tsa kokoana-hloko bakeng sa ho fetisa li-D2R postsynaptic ho NAC kapa dorsal striatum. Re ile ra batlisisa liphello tsa tlhaloso e kholo ea D2R ka thuto ea liletsa, ho ikemisetsa ho sebetsa, tšebeliso ea litlhaloso tsa bohlokoa ea moputso le ho feto-fetoha ha moelelo oa ts'ehetso ka meputso e amanang le moputso.
Ho tepella maikutlo ka morao-rao ka morao D2R ho NAc ho khetha ho eketsa boikemisetso ntle le ho fetola boitšoaro bo senyang, setšoantšo sa boleng ba li-reinforcer, kapa bokhoni ba ho sebelisa moputso bo amanang le litsela ka litsela tse lumellanang le maemo. Ka lehlakoreng le leng, tlhaloso e kholo ea D2R ka lebaleng la striatum ha ea fetola tshebetso mosebetsing ofe kapa ofe.
Kahoo, tumellanong le liphuputso tse ngata tse bonts'ang hore ho fokotsa ho tšoaea D2R ho senya boits'oaro bo susumetsang, tlhaiso-leseling ea rona e bonts'a hore ho tlatlapa ho tlola ha D2R ho NAc ka ho khetheha ho eketsa boikemisetso ba phoofolo ho etsa boiteko ba ho fumana sepheo. Ho fumanoa hammoho, liphetho tsena li fana ka temohisiso ea phello e ka 'nang ea e-ba le liphello tsa mekhoa ea phekolo ea morao-rao e tla ntlafatsa pontšo ea D2R molaong oa NAc.Molecular Psychiatry pele ho inthaneteng, 28 May 2013; doi: 10.1038 / mp.2013.57.
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