Neuropharmacology. 2012 Jun;62(8):2463-71.
Enoksson T, Bertran-Gonzalez J, Christie MJ.
mohloli o moholo
Setsi sa Patlisiso ea Brain le kelello, Univesithi ea Sydney, NSW 2006, Australia.
inahaneloang
Li-opioids ke li-analgesic tse sebetsang empa litlamorao tse mpe tse kang ho mamella le ho tlosoa li kenya letsoho ts'ebelisong ea opioid le ho fokotsa ts'ebeliso ea tsona. Ho tlosoa ha opioid ho kenyelletsa libaka tse ngata tsa boko le e kenyelletsa khatello ea ho lokolloa ha dopamine le ts'ebetso ea li-neurons ho "ventral striatum".
Ka lehlakoreng le leng, opioids e hlobaetsang e eketsa tlhahiso ea dopamine.
Joalo ka ho tlosa, li-opioid tse matla le tsona li kenya li-neurons ka har'a ventral striatum, li fana ka maikutlo a hore lipalo tse fapaneng tsa li-neurral tsa stralatal neurons li ka hlahisoa ka liketso tsa ho tlohela le tse mpe haholo.
Mona, immunofluorescence bakeng sa gene e amanang le kapele-pele, c-Fos, e ile ea hlahlojoa ka mela ea "transgenic reporter" ka li-microscopy tsa confocal ho ithuta palo e ikhethileng ea li-neuron tsa "cyral striatal neurons" tse hlahisitsoeng ke ho tlosoa ha morphine le morphine o hlobaetsang. Kamora morphine e sa foleng, ho nts'etsopela ka sepheo sa ho reroha hoa pele ho tlatselletsa haholo polelo e hlalosang ts'ebetso ea c-Fos, haholo-holo ho D2-receptor (D2R) e boholo bo lekaneng ba li-spiny neurons (MSNs) tsa li-nucleus accumbens (NAc) likarolo tsa mantlha le likhetla. Ka lehlakoreng le leng, a ente e le 'ngoe ea morphine e sebetsang ka ho khetheha c-Fos immunoreactivity ho D1-receptor expression (D1R) MSNs ea mantlha le khetla ea NAc. Liphetho tsena li senola karohano e makatsang ea likarabo tsa neuronal tse etsahalang mananeong a mabeli a li-MSN tsa NAc ho arabela ho tlosoa ha morphine le morphine o boima.
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