J Neurochem. 2015 Jun 26. Doi: 10.1111 / jnc.13209.
Escobar AP1,2, Cornejo FA1,2, Olivares-Costa M1,2, González M1,2, Fuentealba JA1,3, Gysling K1,2, España RA4, Andrés ME1,2.
inahaneloang
Dopamine e tsoang sebakeng sa karoloana ea sekhahla le glutamate e tsoang linotong tse 'maloa tsa boko li kopana ka har'a li-nucleus accumbens (NAc) ho khanna boits'oaro bo susumetsang. Ts'ebetso e phetoang ea li-receptor tsa D2 tse nang le quinpirole (QNP) e etsa hore ho hlohlelletsoe locomotor sensitization le boits'oaro bo qobelloang, empa mekhoa ha e tsejoe. Thutong ena, ho vivo microdialysis le ho hlahloba ka potlako cyclic voltammetry ho likhoto tse kholo tse sa sebetseng li sebelisitsoe ho fuputsa phello ea ho pheta-pheta QNP ho dopamine le glutamate neurotransmission ka hare ho NAc.
Kamora liente tse robeli tsa QNP, ho fokotseha ho matla ha phasic le tonic dopamine ho lokollotsoe ho litoeba tse bonts'ang sensomotor sensitization. Ho na le ente ea systemic kapa infusion ea QNP ho NAc e fokotse ho lokolloa ha dopamine, mme boholo ba phello ena bo ne bo tšoana le QNP-sensitised and control rats, e bonts'a hore inhibitory D2 autoreceptor function e ntse e bolokoa leha ho etsoa ts'ebetso e phetoang ea li-receptor tsa D2 le ho fokotsa dopamine extracellular maemo.
Maemo a bokhopo ba basal extracellular a NAc le 'ona a ne a theohile haholo ho likhoto tse tšoaroang ka QNP ho feta taolong. Ntle le moo, keketseho ea tokollo ea NAc glutamate e susumetsoang ke ts'usumetso e tobileng ea medial prefrontal cortex e ne e le tlase haholo ho likhakanyo tsa maikutlo tsa QNP.
Ka kopanelo, liphetho tsena li bonts'a hore ts'ebetso e pheta-phetoang ea li-receptor tsa D2 e khaola NAc ho tloha sebakeng sa medial prefrontal cortex le sebakeng sa ventral tegmental. Tsamaiso e pheta-phetoang ea dopamine D2 receptor agonist quinpirole (QNP) e tsosa sensitization ea locomotor.
Re fumane hore NAc ea likhoto tse nang le maikutlo a QNP e fokotse litekanyetso tsa glutamate tse tsoang cortex ea pele hammoho le phasic le tonic dopamine neurotransmission e fokotsitsoeng empa tšebetso e bolokiloeng ea presynaptic D2.
Re fana ka maikutlo a hore sensomization ea locomotor ke ka lebaka la boemo bo eketsehileng ba kamano ea D2 post-synaptic receptors.
;
