Pharmacol Biochem Behav. 2013 Aug; 109: 59-66. Doi: 10.1016 / j.pbb.2013.05.002.
Sanna F, Corda MG, Melis MR, Piludu MA, Löber S, Hübner H, Gmeiner P, Argiolas A, Giorgi O.
mohloli o moholo
Lefapha la Saense ea Biomedical, Neuroscience le Clinical Pharmacology Karolo ea 09042 Monserrato, Cagliari, Italy.
inahaneloang
Litlamorao tsa ho kenella ka maqhubu a penile erection le yawning ea subcutaneous (SC) ente ea DopNUMX / D1-joalo ka agonist apomorphine (2-0.02 mg / kg) li ile tsa ithuteloa ho tsoa lihlopheng tsa khale tsa Roma tse phahameng (RHA) le tse thibelang maemo a tlase (RLA). likhoto, mela e 'meli e khetha bakeng sa litheko tsa bona tsa ts'ireletso ka potlako lebokoseng, ebe e bapisoa le litlamorao tse tlalehiloeng ho litoeu tsa banna tsa Sprague-Dawley (SD). Li-curve tsa karabo ea apomorphine ea li-bophahamo li ne li bopehile bell mela le litseng tsohle tsa "rat". Haholo-holo, li-eile tsa "penile erections" le "yawl" li tlalehiloe haholo karolong e nyolohang ea li-curve tsena (mohlala, apomorphine 0.2-0.02 mg / kg) ka har'a likhoto tsa RLA le RHA ha li bapisoa le litoeba tsa SD, 'me likhoto tsa RLA li bonts'a karabelo e phahameng (haholo-holo bakeng sa ho hlohlona ) mabapi le likotsi tsa RHA. Liphetho tse tšoanang li fumanoe ka PD-0.08 (168,077-0.02 mg / kg SC), agonist ea D0.2 receptor agrate, e ileng ea etsa hore penile erection empa e se lerooa. Litekong tsohle tsa litekanyetso, likarabo tsa apomorphine li ile tsa fokotsoa haholo ke D4 antagonist L-2, empa eseng ke mohanyetsi oa D741,626, SB3A, athe bahanyetsi ba D277011 le L-4 le FAUC745,870 ba bile le tšusumetso e itseng. Ka lehlakoreng le leng, phello ea pro-erectile ea PD-213 e felisitsoe ka botlalo ke L-168,077 le FAUC745,870, joalo ka ha ho ne ho lebeletsoe. Phuputso e teng hona joale e tiisa le ho pharalla phapang e tlalehiloeng ea phetisetso ea dopamine lipakeng tsa RLA le likhoto tsa RHA le lipakeng tsa mathata a SD le mela ea Roma. Ho feta moo, e tiisa lithuto tse fetileng tse ts'ehetsang pono ea hore li-dopamine receptors tsa D2 subtype li bapala karolo ea mantlha ts'ebetsong ea pro-yawning le pro-erectile ea apomorphine, le hore ts'usumetso e khethang ea li-receptors tsa D4 e etsa hore motho a tsebe ho etsa lintho tse hlokahalang.
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