Dopamine e bohlokoa ho libido le li-erections. Dopamine e sebetsa ka mefuta e mengata ea li-receptor. Phuputso ena e fumane hore ke D2 dopamine receptor e hlokahalang bakeng sa li-erections. D2 receptor ke eona e ts'oanang le litheko tse ling. Lena ke le leng la mabaka a ho hloka thobalano, le tahlehelo ea takatso ea thobalano le balekane, ho ka hlaha ka ts'ebeliso e mpe ea litšoantšo tsa bootsoa.
Behav Pharmacol. 2009 Jul;20(4):303-11. doi: 10.1097/FBP.0b013e32832ec5aa.
Depoortère R1, Bardin L, Rodrigues M, Sesosa E, Aliaga M, Newman-Tancredi A.
Dopamine (DA) e kenella ho penile erection (PE) le yawning (YA) ka likhoto ka ts'ebetso ea li-receptors tse kang D2. Leha ho le joalo, karolo e tšoanang ea subtype ka 'ngoe (D2, D3 le D4) ea lelapa lena la receptor ho PE / YA e ntse e sa hlakisoa hantle.
Re ile ra rekota ka mokhoa o tšoanang oa PE le YA ka mor'a kalafo le li-agonists tse nang le mekhahlelo e fapaneng ea khethollo bakeng sa li-subtypes tse fapaneng tsa li-receptors tse kang D2. Ntle le moo, re fuputse katleho ea bahanyetsi ka boikhethelo bo ikhethileng kapa bo ikhethileng bakeng sa e 'ngoe le e' ngoe ea li-subtypes tse tharo tse amohelang ho thibela apomorphine-indened PE le YA. Likhoto tsa Wistar li ne li tebile ho feta likhoto tsa Long-Evans tšebetsong ea erectogenic ea aponseistine ea agonist apomorphine (0.01-0.08 mg / kg), athe litoeba tsa Sprague-Dawley li ne li sa tsotelle. Leha ho le joalo, likarolo tsohle tse tharo li ne li ameha ka mokhoa o ts'oanang ho apomorphine-indised YA. Ho litoeba tsa Wistar, apomorphine (0.01-0.63 mg / kg), li-agonists tsa D2 / D3 aginists quinelorane le (+) 7-OH-DPAT (0.000625-10 mg / kg) kapa PD 128,907 (0.01-10 mg / kg), eseng li-agonists tsa D4 agonists PD-168,077, RO-10-5824 le ABT-724 (0.04-0.63 mg / kg), li hlahisitse PE le YA ka li-curls tse nang le sebopeho sa mofuta oa bell. Ka mokhoa o ts'oanang, ABT-724 le CP226-269 (agonist e 'ngoe ea D4) e ile ea hloleha ho khalemela PE le YA ho litoeba tsa Sprague-Dawley. Ntle le moo, litlalehong tsa Wistar, PE le YA tse hlahisitsoeng ke apomorphine (0.08 mg / kg) ha lia ka tsa fetoloa ka ho khetha D3 (S33084 le SB-277011, 0.63-10 mg / kg) kapa D4 (L-745,870 le RBI-257, 0.63 -2.5 mg / kg) bahanyetsi, empa ba ile ba thibeloa ke khethollo ea D2 blocker L-741,626 (mohanyetsi ea haufi le botlalo ho 2.5 mg / kg).
Lintlha tse teng hona joale ha li tšehetse tlhahiso e kholo ea li-D3 tsa DA kapa li-D4 receptors taolong ea PE le YA ka likhoto, empa li bonts'a karolo ea pele ea li-receptor tsa DA D2.
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