mohloli o moholo
Lenaneo la Kalogo ho Neuroscience / Setsi sa Brain Science le Technology, Inje University, Hanwha CC R&D Building, 6 Shinsung Dong, Yusung Gu, Daejun 305-345, Korea Boroa.
inahaneloang
Dopamine le testosterone ea testosterone ke lintlha tsa bohlokoa tse laolang boitšoaro ba banna ba thobalano. Ho etsa lipatlisiso ka monyetla oa hore lintlha tsena tse peli li tsamaisane hantle, re fuputse karolo e ka 'nang ea e mokelikeli oa androgen (AR) ho ea pele transcriptal mosebetsi ea tyrosine hydroxylase (TH) liphatsa tsa lefutso e koahelang enzyme e fokotsang litekanyetso ea tsela ea dopamine biosynthesis. Thutong ena, ho sebelisa phetisetso ea nakoana ea ho fetisetsa phetisetso liseleng tsa TH-positive SK-N-BE (2) C le MN9D, re bonts'a hore AR e phahamisa haholo ts'ebetso ea morekisi oa TH ka mokhoa o itšetlehileng ka ligand. Litlhatlhobo tse fetotsoeng tse fetotsoeng le tse tsamaisoang ke sebaka sa marang-rang li utloisitse bohloko androgen element element ea karabelo (are) sebakeng se tsoang ho -1562 ho ea ho -1328 li-pairs tsa lipapatso molemong oa phahamisa. Hape re fumane hore DJ-1, e mong oa ba sa tsoa khetholloa liphatsa tsa lefutso eo liphetoho tsa eona li bakang lefu la Parkinson, ts'ehetso e tlase ea AR e itšetlehileng ka ts'ebetso ea AR ka hoo e ka bang 50% ho lisele tsa SK-N-BE (2) C. Ho ipapisitsoe le lintlha tsena, re etsa tlhahiso ea hore AR e sebetse TH liphatsa tsa lefutso polelo le hore DJ-1 e kanna ea fetolela AR mosebetsi e le transcriptal mohatelli.
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