Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis Monghali.
Neuropharmacology. 2006 Dec 9; Bernard B Brodie Lefapha la Neuroscience, Setsi sa botle ba The Neurobiology of Addictions, Univesithi ea Cagliari, SP Sestu-Monserrato, Km 0.700, 09042 Monserrato, CA, Italy; Setsi sa Neuroscience, Lekhotla la Sechaba la Lipatlisiso, Karolo ea Cagliari, 09042 Monserrato, Italy.
Litlamorao tsa pro-erectile lethal dose ea apomorphine, dopamine receptor agonist e kopaneng, le PD-168077 (N- [4- (2-cyanophenyl) piperazin-1-ylmethyl] -3-methylbenzamide maleate, dopamine dopamine receptor agonist, e kentsoeng ka har'a paturu ea cellular ea hypothalamus ka har'a khatello ea dopamine e eketsehileng-cellular le metabolite ea eona ea sehlooho ea 4-dihydroxyphenylacetic acid (DOPAC) ho dialysate e tsoang ho li-nucleus accumbens e ithutile ho litoeba tsa banna. Joalokaha ho lebelletsoe, apomorphine (3,4mug) le PD-0.1 (168077mug) li ile tsa etsa hore li-epile tsa li-penile erection li etsahale ka mokhoa o ts'oanang le keketseho ea li-dopamine tse eketsehileng tsa cellular le mahlahana a DOPAC ka dialysate ho tloha khetla ea li-bokellase tsa nucleus, joalo ka ha e lekantsoe ke intracerebral microdialysis. Ha o susumetsoa ke apomorphine, litlamorao tsena li fokotsoe ke 0.1% ke morusu, D80 / D2 receptor antagonist (3mug) mme ke 1-40% feela ka L-45 (745,870mug), selekane se kopanyang dopamine. Ha o susumetsoa ke PD-1, litla-morao tsena li ile tsa fokotsoa ke 4% ho feta ka L-168077 (80mug), empa e ne e le 745,870-1% feela ka raclopride. Ho sa tsotelehe ka agonist ea dopamine e sebelisetsoang ho etsa hore penile erection, phello ea pro-erectile le keketseho e kopanetsoeng ea dopamine le khatello ea DOPAC ka har'a dialysate tsa nucleus li se li felisitsoe ka ho felletseng ke d (CH (35)) (40) Tyr (Me (2) ) -Orn (5) -vasotocin (2mug), mohanyetsi ea matla oa oxytocin receptor, ea fanoeng lits'ebetsong tsa morao.
Liphetho tse teng hona joale li fana ka maikutlo a hore ho hlohlelletsoa ha li-receptor tsa dopamine (haholo-holo ea D2 ho D4 subtype) ka har'a nucleus ea methapo ea kutlo e etsa hore ho fanoe ha oxytocin libakeng tsa boko tse susumetsang ts'ebetso ea mesolimbic dopaminergic neurons e pakeng tsa takatso ea lijo le matlafatso ea tšebetso ea thobalano. Sena se fana ka. bopaki bakeng sa karolo ea oxytocin makaleng a neural a kopanyang ts'ebetso ea litsela tsa neural tse laolang likarolo tsa boitšoaro bo amanang le thobalano (mohlala, penile erection) le ba laolang takatso ea thobalano le takatso ea thobalano.
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