Emil Egecioglu, Luna Prieto-Garcia, Erik Studer, Lars Westberg le Elisabet Jerlhag*
Ntho ea pele e hatisitsoeng Inthaneteng: 4 DEC 2014
Keywords:
- Tlatsetso;
- takatso ea lijo;
- dopamine;
- ghrelin;
- moputso;
- boits'oaro
inahaneloang
Ghrelin, lets'oao la kelello ea ka mpeng, le tsebahala ho laola homeostasis ea matla, takatso ea lijo le takatso ea lijo ka pele ka li-receptors tsa hypothalamic ghrelin (GHS-R1A). Ntle le moo, ghrelin e kenya tšebetsong methapo ea moputso bokong, e leng sistamine ea mesolimbic dopamine, 'me e laola thepa e hlasimollang ea lithethefatsi tse tlatsetsang hammoho le lijo tse matlafatsang. Kaha re le mesolimbic dopamine sistimi e laela thepa e matlafatsang ea lithethefatsi tse tlatsetsang le meputso ea tlhaho, joalo ka boitšoaro ba thobalano, re nahana hore ghrelin e bapala karolo ea bohlokoa bakeng sa boitšoaro ba monna ba thobalano, e leng thuto bakeng sa lithuto tsa hona joale. Mona re bontša hore kalafo ea ghrelin ea eketseha, athe khatello ea meriana (GHSR-1A antagonist JMV2959) kapa ho tlosoa hoa liphatsa tsa lefutso tsa GHS-R1A ho litoeba tsa banna ho fokotsa maikutlo a thobalano le boitšoaro ba thobalano le litoeba tsa basali ho oestrus. Phekolo ea pele le L-dopa (dopamine preursor) pele ho kalafo le JMV2959 e ile ea eketsa khetho ea mouse ea basali haholo ha e bapisoa le kalafo ea makoloi. Ho fapana le hoo, kalafo e nang le 5-hydroxythyptohan (selelekela sa serotonin) pele ho kalafo le JMV2959 e ile ea fokotsa tšusumetso ea thobalano ha e bapisoa le koloi. Litekong tse fapaneng, re bonts'a hore moea oa moea oa boea oa Grel le RHS-R1A ha li ame nako e sebelisitsoeng holim'a boroko ba basali joalo ka ha ho lekantsoe litekong tsa bethe tse itšetlehileng ka androgen. Ka kopanelo, lintlha tsena li bonts'a hore lihormin tse matla tsa tlala le se e amohelang li hlokahala bakeng sa boitšoaro bo tloaelehileng ba thobalano le litlamorao tsa mokhoa o supang ts'ebetso ea thobalano litabeng tsa thobalano li kenyelletsa dopamine neurotransmission.
Bafuputsi ba fumana li-hormone tse eketsang mofuta oa litoeba tsa thobalano
Litaba: Jan 20, 2015
Liphuputso tsa Sweden li bonts'a litoeba tse fumanang tlatsetso ea "hormone ea takatso ea lijo" ghrelin li eketsa thobalano. Hore na hormone e na le tšusumetso e tšoanang ho batho ha ho tsejoe - empa haeba ho joalo, bafuputsi ba kanna ba fumana senotlolo sa kalafo ea kamoso ea tlhekefetso ea thobalano.
Ghrelin ke hormone ea ka mpeng e tsoang ka mpeng, 'me e ameha mohopolong oa takatso ea rona ea lijo ka ho kenya tšebetsong tsamaiso ea moputso oa boko.
Kaha ts'ebetso ea moputso oa boko e boetse e re susumetsa ho batla molekane le ho etsa thobalano, sehlopha sa bafuputsi sekolong sa Sahlgrenska se nkile qeto ea ho etsa lipatlisiso hore na ghrelin e ka ama le boitšoaro ba thobalano.
Phello e netefalitsoeng
Karabo ke: e, bonyane ho litoeba.
Phuputsong, bafuputsi ba bonts'a hore ha litoeba li fumana tlatsetso ea bongaka, li eketsa ts'ebetso ea bona ea thobalano le boiteko ba bona ba ho fumana molekane. Tšusumetso e tiisoa tlhahlobong ea morao-rao, moo litoeba tse amohetseng ghrelin inhibitor ho fapana le moo li fokotsitseng ts'ebetso ea bona ea thobalano.
"Ho se ho tsebahala hore ghrelin e ama mekhoa ea meputso e hlahisoang ke lijo, joala le lithethefatsi tse ling tse lemalloang. Boithuto ba rona hona joale bo bontša ka lekhetlo la pele hore ghrelin e boetse e bapala karolo ea tšebetso ea meputso ea tlhaho joaloka thobalano, "ho bolela Elisabet Jerlhag, mofuputsi Sekolong sa Sahlgrenska.
Ho hlokahala patlisiso e eketsehileng
Lithuto li bonts'a hore litlamorao tsa ghrelin li hlahisoa ka dopamine, e leng len messengerosa le tsebahalang le la bohlokoa tsamaisong ea moputso ea boko. Qeto ea bafuputsi ke hore ghrelin le dopamine li laola boitšoaro bo tloaelehileng ba thobalano ho litoeba.
"Leha ho le joalo, sena ha se bolele hore moea o mongata o phethesela batho. Ho fumana ho hloka patlisiso e kholo haholoanyane sebakeng seo. Empa li-ghrelin inhibitors e kanna ea ba senotlolo sa kalafo ea kamoso bakeng sa ho lemalla tlhekefetso ea thobalano le tlhekefetso ea thobalano, "ho bolela Elisabet Jerlhag:
"Boitšoaro bo bobebe, ho kenyelletsa tlhekefetso ea thobalano, ke a mang a mathata a rona a maholo sechabeng, 'me ho na le tlhoko e kholo ea maano a macha a kalafo. Re tšepa hore, litholoana tsa rona li ka eketsa karolo e 'ngoe ea papali ena mosebetsing ona, ”ho bolela Elisbet Jerlhag.
Sehlooho sena Karolo ea ghrelin e supang boitšoaro ba thobalano ho litoeba tsa banna e phatlalalitsoe inthaneteng koranteng ea Addiction Biology ka la XDUMX.
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