Lijo tse nang le mafura a mangata tse kopantsoeng le ho hloka lijo li eketsa ho batla lijo le polelo ea batho ba nang le bothata ba ho lemala. (2016)

Moetso oa panya o qapiloe ho ithuta phello ea mafura a lijo tse kopaneng le linako tsa ho nona lijo ka har'a lijo tse fumanehang hape mabapi le polelo ea li-biomarkers tse tharo tse ka lemalloang ho fungusate hydratase (FH), ATP synthase subunit alpha (ATP5a1) le transketolase (TKT). Malinyane a mane a C57BL / 6 J, a libeke tse 'ne, a feptjoa ka lijo tse nang le mafura a mangata (HF) kapa lijo tse tloaelehileng tlasa liteko. Kamora libeke tsa 3 tsa ho fepa ka mokhoa o fapaneng, liphoofolo li ile tsa fana ka nako ea libeke tse peli tsa koetliso ea libeke tse peli tsa letsatsi le letsatsi moo litekanyetso tse bonoang li neng li penteloa ho lijo tse monate (lijo-thollo tsa chokolete) kapa ho hang lijo. Koetliso ena e ile ea nka nako e telele beke e le 'ngoe e tšoanang, lithuto tse le' ngoe tsa letsatsi le letsatsi tse etelletsoeng pele ke tlhoko ea lijo tsa 12. Teko ea boits'oaro e ile ea qetella e etsoa moo litoeba li kentsoeng metsotso ea 30 ebang ke likamoreng tse sa lefelloeng tsa lijo kapa ka har'a liphaposi tse neng li entsoe pele ka lijo-thollo, empa joale li na le lipampiri tsa lijo tse se nang letho. Ketsahalo e felletseng nakong ea tlhahlobo ena ea boits'oaro le litekanyetso tsa serum corticosterone hang hoba li be joalo ka lihlopha tsohle tsa liteko. Lits'ila tse lekiloeng litsing tse kengoang ke lijo li bonts'itse khetho ea letšoao la lijo le se nang letho leo butle-butle le nyamelang ho batho ba fephileng ba phehang hantle empa ba phehella ho litoeba tse phehiloeng ke HF. Litoeba tse nang le phepo ea HF le tsona li hatisitse FH, ATP5a1 le TKT, e lumellanang hantle le ho phehella ha khetho ea lijo tse se nang letho. Ho khothaletsoa hore lijo tsa HF li kopane le phokotso ea lijo li ka ntlafatsa mekhoa ea ho batla lijo ha ba ntse ba nyalisa FH / ATP5a1 / TKT, eo hape e nahanoang e le li-biomarkers tsa bokhoba ba tahi.