Litlhaloso: Thuto e hlahlobisitsoe lik'hemik'hale tse ngata tsa methapo ea pelo le liprotheine tse kenyelletsang lithethefatsi. Thuto e fumane liphetoho tse tšoanang tse nang le boits'oaro bo tšoanang le litoeba tse fetiloeng ka lijo tse mafura haholo tse mafura.
Int J Obes (London). 2012 Dec 11. doi: 10.1038 / ijo.2012.197.
Sharma S, Fernandes MF, Fulton S.
mohloli o moholo
CRCHUM le Montreal Setsi sa Lipatlisiso sa lefu la tsoekere; Lefapha la phepo e nepahetseng, Sekolo sa Bongaka, Univesithi ea Montreal, Montreal, Quebec, Canada.
inahaneloang
Morero:
Ho khetholla mekhoa ea maikutlo le ts'ehetso e tsosolosang lijo tse hlabosang ka mor'a ho tlosoa ha lijo tse mafura haholo (HFD) le li-neuroadaptations tse amanang le lik'hemik'hale tse amanang le methapo ea maikutlo le ea boitšoaro tlas'a ts'ebetso ea dopaminergic.
Mekhoa:
Batho ba baholo banna ba C57Bl6 litoeba ree behoa ka mafura a HFD (58% kcal) kapa lijo tse kopantsoeng, tse fokolang mafura (LFD; 11% kcal fat) bakeng sa libeke tsa 6. Qetellong ea lijo-litoeba li ne li lula lijong tsa bona, kapa HFD le LFD li nkeloa sebaka ke chow e tloaelehileng (ho tlosoa).
Basebetsi ba thehiloeng ka boiteko ba ho arabela sucrose le meputso ea lijo tse mafura haholo ba ne ba lekanngoa hammoho le maemo a basal le a bakoang ke khatello ea kelello ea corticosterone le matšoenyeho (le-plus plus maze). Liprotheine tsa tyrosine hydroxylase (TH), corticosterone e lokollang mofuta oa mofuta oa 1 receptor (CRF-R1), neurotrophic factor e fumanoang ke boko (BDNF), phospho-CREB (pCREB) le ΔFosB (e fapaneng ea sefate sa FosB) e ile ea hlahlojoa ka amygdala , nucleus accumbens (NAc) le sebaka sa ventral tegmental (VTA) ka tsela e ka bophirimela ea immunoblotting.
Results:
Libeke tse tšeletseng tsa HFD tse etsang hore ho be le boima bo boima bo ile ba etsa hore ho fokotsehe anhedonia, boitšoaro bo kang bo tšoenyehileng le hypothalamic-pituitary-adrenocortical axis (HPA) hypersensitivity ho hatella. Ho tlosoa ho tloha HFD empa eseng LFD-ho tšoenyeha ho ka 'nang ha e-ba teng le basal corticosterone le litekanyetso tse matlafatsang bakeng sa sucrose le moputso oa lijo tse mafura haholo.
Ho fepa ka mafura ho sa feleng ho fokotsehile CRF-R1 mme ho eketseha ha BDNF le pCREB liprotheine maemong a amygdala le ho fokotsoa TH le ho eketsa protheine ea ΔFosB ka NAc le VTA. Ho fokotsa lijo tse monate tse fanang ka moputso ho litoeba tse tlosoang HFD li tsamaisane le ho eketseha ha liprotheine tsa BDNF ho NAc le ho fokotseha TH le pCREB polelo e hlahang ho amygdala.
fihlela qeto ena:
Anhedonia, ho tšoenyeha le kutloisiso ea khatello ea kelello ho hlaha nakong ea HFD 'me e ka ba le karolo ea bohlokoa mokhoeng o sehlōhō o ntseng o tsoela pele ho fepa mafura le ho ntlafatsa botenya. Ho tlosoa ha HFD ho eketsa likarabo tsa khatello ea maikutlo le ho eketsa ts'oaetso ea lijo tse monate ka ho eketsa boitšoaro bo susumelletsang lijo. Liphetoho tse tšoarellang dopamine le lipontšo tsa polasetiki tse amanang le potoloho ea moputso li ka 'na tsa khothalletsa lipolelo tsa maikutlo tse nyahamisang, ho ja lijo tse matlafatsang le tse monate.
Mokhatlo oa Machaba oa Boima bo Botenya o ntseng o hatisoa ka inthaneteng, 11 December 2012; doi: 10.1038 / ijo.2012.197.
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