LIPOTSO: Tlhahlobo ea bohlokoa haholo e bonts'ang li-receptor tsa DopNUMX tsa dopamine li khutlela ho tloaelehileng kamora ho lahleheloa ke boima bo potlakileng ka lebaka la ts'ebetso ea mpa ea mpa. Taba ea mantlha, sena se bontša hore ba ileng ba nona haholo ba ne ba se na khatello ea kelello e kileng ea e-ba teng. Taba ea bobeli, e bonts'a hore tšebeliso e ngata ea meputso ea tlhaho e ka baka ts'abo. Taba ea boraro, e bonts'a hore methapo e ka khutlela ho tloaelehileng ha ts'ebeliso e ngata e tlosoa.
Mabaka Surg. 2010 Mar; 20 (3): 369-74. doi: 10.1007 / s11695-009-0015-4. Epub 2009 Oct 29.
Steele KE1, Prokopowicz GP, Schweitzer MA, Magunsuon TH, Lidor AO, Kuwabawa H, Kumar A, Brasic J, Wong DF.
Lefapha la Ts'ebetso, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. [imeile e sirelelitsoe]
inahaneloang
LITLHAHISO:
Le ha ts'ebetso ea bongaka ea bariatric e ipakile e atlehile haholo ho hlahiseng boima ba 'mele, phapang ea phetoho ea kalafo e ntse e tsoela pele. Kutloisiso e ntlafalitsoeng ea pathophysiology ea takatso ea lijo le botenya e ka ntlafatsa khetho ea bakuli le taolo. Patlisiso mabapi le boitšoaro ba ho fepa le ho satiety e shebile karolo ea dopamine boits'oarong bo thehiloeng ho moputso. Ka ho khetheha, positron-emission compute tomography (PET) e bonts'itse phokotso ea ho fumaneha ha dopamine receptor lithutong tse nyane ha li bapisoa le taolo. Sena se kanna sa bakoa ke khaello ea mantlha ho li-dopamine receptor kapa sekhahla sa dopamine receptor. Re entse lipatlisiso tsa mantlha ho etsa lipatlisiso tsa dopamine D2 receptor mesebetsi lithutong tse tlotsitsoeng pele le kamora laparoscopic Roux-en Y gastric bypass (LGBP).
LITLHAHISO:
Lithuto tse hlano tsa basali, lilemo tsa 20 ho isa ho 38 ea lilemo tse nang le index ea boima ba 'mele ea 45, e fanoe ka PET ka ente ea [C-11] ea raclopride. Ho ithutile libaka tse hlano tse khahlisang: li-ventral striatum, anterior le posterior putamen, le anterior le posterior caudate nucleus. PET e pheta-phetoang e entsoe libekeng tsa 6 tse latelang LGBP. D2 e amohelang receptor e ne e bapisoa ka hare ho lithuto pele le ka mor'a ho buuoa. Ho tlama Basyl D2 ho boetse ho bapisoa le taolo ea nonobese ea nalane.
LIKOTSO:
Ho fumaneha ha li-receptor tsa D2 ho eketsehile libeke tsa 6 kamora ho buuoa ka gastric bypass. Keketseho ea phallo ea li-receptor e bonahetse e lekana le tekanyo ea boima bo lahlehileng. Ha ho phapang e kholo litlamong tsa D2 e boneng lipakeng tsa lithuto tse batenya le taolo ea nonobese ea nalane.
CONCLUSIONS:
Bopamine e fumanehang ea dopamine D2 e bonahala e eketseha ka morao ho GBP. Ts'ebetso ena ea mantlha e hloka ho phetoa sechabeng se seholo empa fana ka maikutlo a hore ho fokotsa D2 ho tlama hoa makhopho ho feta ka lebaka la D2 receptor. Liphetoho tsa ho tlama dopamine receptor binding li ka bapala karolo ea bohlokoa ho hatelleng takatso ea bohareng ba takatso ea lijo le ho fokotsa boima ba 'mele ka mor'a LGBP.
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