Ka pel'a Hum Neurosci. 2017 Aug 3; 11: 386. doi: 10.3389 / fnhum.2017.00386.
Wu C1, Garamszegi SP2, Xie X2, Mash DC1,2.
inahaneloang
Pontšo ea Dopaminergic tseleng ea moputso bokong e 'nile ea bontšoa hore e phetha karolo ea bohlokoa ho keneng lijo le ho ntlafatsa botenya. Likokoanyana kaofela li lokolla tekanyo e fokolang ea dopamine (DA) nucleus accumbens (NAc) ka mor'a lijo, 'me amphetamine e etsa hore ho lokolloa ha DA e hlasetsoeng ho fokotsoe Ka vivo ka lihlooho tse ngata. Liphuputso tsena li bontša hore boikaketsi ba DA bo amanang le hedonic dysregulation bo ameha ho pathophysiology ea botenya.
Ho lemoha liphetoho tsa boko bo botenya, litekanyo tsa boleng ba li-marker tsa synaptic tsa DA li ne li bapisoa le li-tissu tsa boko bo tloaelehileng tsa boima ba 'mele le lihlooho tse ngata ho feta mefuta e mengata ea boima ba' mele (BMI). Linaha tsa DA transporter (DAT) li ne li tšoantšoa le pontšo e amanang le DAT, tyrosine hydroxylase (TH) le D2 dopamine receptors (DRD2) har'a methapo ea DA. Radioligand e tlama litlhahlobo tsa [3H] WIN35,428 e bonts'itse hore palo ea libaka tsa ho thibela DAT e hlaselang e ne e amana le ho eketseha ha BMI (r = -0.47; p <0.01). DAT le TH ea liphatsa tsa lefutso li ile tsa fokotseha haholo ka kamoreng ea somatodendritic ea lihlooho tse matla haholo (p <0.001), ntle le phetoho e kholo ho DRD2 ha e bapisoa le litaba tse tloaelehileng tsa boima. Palo e fokotsehileng ea DAT e hlaselang le ho fokotseha ho fokolang ho DAT le TH ea liphatsa tsa lefutso ka substantia nigra (SN) e bontša, hore botenya bo amahanngoa le mosebetsi oa hypodopaminergic. Ho 'nile ha boleloa hore ho na le lefu la khaello ea DA bakeng sa ho haelloa ke boloetse ba ho ja tloaelo e sa tloaelehang e lebisang boteng. Liphetoho tsa "neurobiological" ho batho ba "DA" tsa presynaptic tsa DA li bontšitse postmortem ka boko ba motho ho tšehetsa maqhama pakeng tsa ho fokotsa ha DA le ho nona haholo.
LINKOTSO:
BMI; dopamine receptor; dopamine mohlokomeli; botenya; striatum; substantia nigra; tyrosine hydroxylase
PMID: 28824395
PMCID: PMC5541030
;
