Ho ja lijo tsa ho jela ka nako e telele le ho ipholosa. Litabeng tsa ho kopanela liphate ka mokhoa oa ho etsa liphatsa tsa lefutso tsamaisong ea moputso oa mesolimbic (2013)

Takatso ea lijo. 2013 Jun; 65: 189-99. Doi: 10.1016 / j.appet.2013.01.014.

Ong ZY1, Wanasuria AF, Lin MZ, Hiscock J, Muhlhausler BS.

inahaneloang

Boithuto bo hlahlobang phello ea khafetsa ea lijo tse matlafatsang ts'ebetsong ea moputso oa mesolimbic li se li entsoe feela ho banna. Phuputso ena e etselitsoe ho fumana litlamorao tsa ho ja lijo tse matlafatsang tsa kofi e sa feleng le ho se fuoe mafura a mangata, ho ja lijo le mokhoa o ka sehloohong oa mofuta oa moputso oa mesolimbic ho banna le basali. Liroto tsa Albino Wistar li ile tsa feptjoa libeke tsa 8 ho li-chow tse tloaelehileng (Taolo, n = banna ba 5, basali ba 5) kapa li-cafeteria tse jeoang (CD; n = banna ba 16, basali ba 16). Lijo tsa k'habeche li ile tsa tlosoa setsing sa likhoto tsa CD bakeng sa 72 h (sehlopha sa CD-Withdrawal, CD-W). Li-nucleus accumbens (NAc) li ne li qheletsoe ka thoko 'me polelo ea mRNA ea tyrosine hydroxylase (TH), transporter e sebetsang ea dopamine (DAT), D1 le D2 dopamine receptors, le μ-opioid receptor e khethiloeng ke qRT-PCR.

Ho ja lijo tse matlafatsang tsa ka nako e telele li ile tsa eketsa boima ba 'mele litsong tsohle tsa CD empa boima ba' mele le tšebeliso ea 'mele li ile tsa fokotsoa nakong ea ha ho ne ho sa jeoa lijo tsa kahare. TH mRNA e ile ea fokotsoa ho likhoto tsa CD le tsa CD-W, empa ea eketseha ka likhoto tsa CD le tsa CD-W. D1 mRNA e fokotsehile ho basali ba CD le CD-W, empa ea eketseha ho banna ba CD, ha e bapisoa le Controls. Polelo ea ept-opioid receptor e fokotsehile ho banna ba CD le CD-W empa eseng basali.

Lintlha tsena li bonts'a bohlokoa ba ho fuputsa karohano ea thobalano karabong ea methapo ea kutlo ho lijo tse fumanehang habonolo le tlhoko ea lithuto tsa nako e tlang sebakeng sena ho kenyelletsa bong ba bobeli.

PMID: 23402719

DOI: 10.1016 / j.appet.2013.01.014