Neurosci Lett. 2015 Mar 4; 589: 1-6. Doi: 10.1016 / j.neulet.2015.01.019.
Zhang C1, Wei NL2, Wang Y3, Wang X3, Zhang JG1, Zhang K4.
inahaneloang
Morero oa phuputso ena e ne e le ho lekola litlamorao tse khahlano le botenya ba li-nucleus accumbens shell (NAc-sh) tse tebileng tsa hlohlelletso ea boko (DBS) ho likhoka tse tlisoang ke ho ja (DIO) le likhoto tsa chow-fed (chow). Ts'usumetso ea DBS ho ho saena ha dopamine (DA) ho NAc-sh le eona e ile ea hlahlojoa. Li-DIO le likhoto li ile tsa fuoa DBS matsatsi a 14 a latellanang. Ho ja lijo le ho eketsa boima ba 'mele ho ne ho lekantoa letsatsi le letsatsi. Tlhaloso ea lefutso ea li-receptor tsa Dopamine D1 le D2 e ile ea hlahlojoa ke qPCR. Ntle le moo, maemo a kantle ho lisele tsa DA le metabolite ea eona, dihydroxyphenylacetic acid (DOPAC), a ile a khethoa ke microdialysis. Re hlokometse hore DBS e sa foleng e bakile phokotso e kholo ea phepelo ea matla a felletseng (596.0 ± 65.0kcal vs. 1161.6 ± 22.2kcal, p <0.001) le boima ba 'mele (1.45 ± 0.57% vs. 9.64 ± 0.38%, p <0.001) ho likhoto tsa DIO ha e bapisoa le sham-DIO likhoto. Phatlalatso ea liphatsa tsa lefutso ea D2 receptor (2.43 ± 0.12 vs. 0.64 ± 0.04, p <0.001) le maemo a eketsehileng a DA (2.73 ± 0.15pmol / mL vs. 0.62 ± 0.05pmol / mL, p <0.001) e ile ea bonoa likhoto tsa DIO ha e bapisoa le sham-DIO likhoto. DBS e ne e se na tšusumetso ea ho ja, ho eketsa boima ba 'mele, kapa ho fetisetsa methapo ea kutlo ea DA ho likhoto. Liphetho tsa rona li ts'ehetsa mokhatlo oa litlamorao tsa anorexigenic tsa NAc-sh DBS tse nang le lets'oao la DA la mesolimbic mme li bonts'a hore phetoho e ntle ea ts'ebetso ea DA ho likhoto tsa DIO e ka ba le boikarabello ba litlamorao tse fapaneng tsa DBS ho DIO le chow rats.
LINKOTSO: Matla a tebileng a kelello; Dopamine; Li-shell tsa nyutlelie; Ho Nona Haholo
PMID: 25578952
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