Psychopharmacology (Berl). 2012 Mar;220(1):173-81. doi: 10.1007/s00213-011-2468-0.
Finger BC1, Dinan TG, Cryan JF.
inahaneloang
TLHOKOMELISO:
Sisteme ea ghrelinergic e bohlokoa molemong oa kholo ea botenya le ho chencha lithula tsa moputso o bohareng. Ho tlalehiloe hore botenya bo khothalletsoang ke ho ja bo baka karabelo e pharalletseng mabapi le tšebeliso ea lijo ho tsamaiso ea ghrelin, e amanang le ho hanyetsana ha ghrelin. Mona re fuputsa hore na litlamorao tsa matla tsa ghrelin tsamaisong ea moputso li fetotsoe litoebeng tse nang le phepo e ntle ea phepo.
LITLHAHISO:
Ho nona ho ile ha eketsoa ho litoeba tsa C57BL / 6J ka ho fepa lijo tse nang le mafura a mangata bakeng sa libeke tsa 13. Limpisi li ile tsa koetlisetsoa mosebetsi o sa khaotseng oa ho sebetsa bakeng sa ho fumana moputso o motle. Sebakeng sa papatso sa libes, ghrelin le mohanyetsi oa ghrelin receptor ba ile ba tsamaisoa ka tekanyo e tsoelang pele. Liphetoho tse ka hare ho sistimi e kholo ea li-ghrelin ho litoeba tse amanang le ho ja li ile tsa hlahlojoa.
LIKOTSO:
Litoeba tsa Obese li bontšitse ho fumana le ho sebetsa ho paradigm e tsitsitseng le e tsoelang pele. Habohlokoa ka ho fetesisa, botenya bo khothalletsoang ke ho ja bo sitisitse litlamorao tse matlafatsang tsa ghrelin (2 nmol, 3 nmol / 10 g) ka tekanyo e tsoelang pele ea karabelo ha liphoofolo tse bonolo li hlahisoa ka karabelo e eketsehileng. Tsamaiso ea "ghrelin-receptor antagonist" (D-Lys (3)) - GHRP-6 (66.6 nmol / 10 g) e fokotse ts'ebetso ho litoeba tse mpe empa eseng haholo. Boikutlo bona ba ho hloka matla ho ghrelin receptor ligands ka litoeba mabapi le lijo tse nang le mafura a mangata bo ile ba tšehetsoa haholo ke polelo ea "mRNA" e fumanehang ea ghrelin receptor ho hypothalamus le ho bokellana ha methapo ho litoeba tse feteletseng.
CONCLUSIONS:
Boithuto bona bo bonts'a hore litlamorao tsa phetoho ea ligrelin receptor ligands li soeufalitsoe ka mohlala oa panya ea botenya bo khothalletsoang ke lijo tse tsoelang pele. Ka hona, datha ea rona e holisa ho hanyetsa ho hlalositsoeng ha pele ho litla-morao ho litoeba tsena ho tloha ho ja lijo ho ea ho boits'oaro bo amanang le moputso.
PMID: 21892647
DOI: 10.1007/s00213-011-2468-0
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