Psychoneuroendocrinology. 2015 Oct; 60: 206-16. Doi: 10.1016 / j.psyneuen.2015.06.018. Epub 2015 Jul 3.
Ntsu S1, Cornejo MP1, Reynaldo M1, De Francesco PN1, Perello M2.
inahaneloang
Ho itlopa joala ke boitšoaro bo bonoang mathateng a fapaneng a batho a ho ja. Likhoto tsa Ad libitum tse fepehileng letsatsi le letsatsi le nako e lekantsoeng li pepesetsoa phepelo ea mafura a mangata (HFD) li bonts'a liketsahalo tse matla tsa ho itlopa joala tse ntseng li eketseha butle butle ho feta phihlello ea pele. Keketseho ea tlhahiso e hlahisoa hore e be karolo ea phetoho ho tloha taolong ho ea taolong ea boitšoaro bo qobelloang kapa tahlehelo. Mona, re sebelisitse motswako oa lithuto tsa boits'oaro le neuroanatomical ho litoeba letsatsi le letsatsi le nako e lekantsoeng e pepesitsoeng ho HFD ho fumana sepheo sa boko ba neuronal se kenngoe - joalo ka ha ho bonts'itsoe ke lets'oao la ts'ebetso ea lisele tsa c-Fos - tlasa maemo ana. Hape, re ne re sebelisa litoeba tse sebetsanang le litlhare kapa lefutso ho ithuta karolo ea orexin kapa pontšo ea ghrelin, ka ho latellana, ho feto-fetoha ha boitšoaro bona.
Re fumane hore tse 'nè tsa letsatsi le letsatsi le nako e lekanyelitsoeng ea ho fumana monyetla oa HFD: (i) hyperphagia e matla e nang le profil e ntseng e phahama, (ii) ts'ebetso ea likarolo tse fapaneng tsa sebaka se tlase sa dopamine neurons le li-neurons tseo ka kakaretso e leng , e tsebahatsoang haholo ho feta ts'ebetso e hlokometsoeng kamora ketsahalo e le 'ngoe ea tšebeliso ea HFD, le (iii) ts'ebetso ea ts'ebetso ea methapo ea kutlo ea orexin, leha orexin e tšoaeang blockage e sitoa ho ama ho nyoloha ha tšebeliso ea HFD. Ntle le moo, re fumane hore litoeba tse haelloang ke moea oa "ghrelin receptor" li haella ho matlafatsa tšebeliso ea HFD ka matsatsi a latellanang a ho pepeseha le ho kenya ts'ebetsong tsela e kholo ea mesolimbic ho arabela ts'ebeliso ea HFD. Boitsebiso ba hajoale bo fana ka maikutlo a hore ho nyoloha ha tšebeliso ea mafura a mangata nakong ea phetoho e fapaneng khafetsa ho kenyelletsa li-dopamine neurons tsa sebaka sa karo-karolelano ea ventral mme ho hloka hore ho be le Ghost signin.
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