Obes Res. 2002 Jun;10(6):478-88.
Colantuoni C, Rada P, McCarthy J, Patten C, Avena NM, Chadeayne A, Hoebel BG.
inahaneloang
MORERO:
Morero e ne e le ho bona hore na ho tlohela tsoekere ho ka baka matšoao a ho itšetleha ka opioid. Hobane lijo tse matlafatsoang li matlafatsa lits'ebetso tsa neural tse amehang tšebelisong ea lithethefatsi, ho ne ho nahanoa hore nako le nako, tšebeliso e matla ea tsoekere e ka baka ts'ehetso, joalo ka ha ho bonts'oa ke matšoao a bang teng.
Mekhoa ea Phuputso:
Liraka tsa banna li ne li fuoe lijo bakeng sa lihora tsa 12 letsatsi le leng le le leng, ho kenyelletsa le lihora tsa 4 lefifing la pele, ebe li fana ka tsoekere e ntle haholo ea 25% ho ekelletsa ho chow bakeng sa lihora tse latelang tsa 12. Ho ikhula ho ne ho susumetsoa ke naloxone kapa ho hloka lijo. Matšoao a ho tlohela a ne a lekantsoe ke ho shebella, ho rekota lirafshoa, le liteko tse phahameng tsa maze, le ho vivo micodialysis.
LIKOTSO:
Naloxone (20 mg / kg intraperitoneally) e ile ea baka matšoao a somatic, a kang ho oka meno, ho thothomela esale pele le ho thothomela hoa hlooho. Khaello ea lijo bakeng sa lihora tsa 24 li bakile matšoao a ho itlosa bolutu, a kang ho oka meno. Naloxone (3 mg / kg subcutaneally) e bakile nako e fokotsehileng letsohong le pepesitsoeng la maze e phahameng, moo ho neng ho tlalehiloe meno ea bohlokoa hape. Tšusumetso ea mats'oenyeho a kopaneng e ile ea phetoa le lihlopha tse 'ne tsa taolo bakeng sa papiso. Accumbens microdialysis e senotse hore naloxone (10 le 20 mg / kg intraperitoneally) e fokotsehile extracellular dopamine (DA), ha litekanyetso li ntse li eketsa acetylcholine (ACh). Ho se leka-lekane ha lesixone-indened DA / ACh ho ile ha phetoa ka 10% sucrose le 3 mg / kg naloxone subcutaneally.
TŠOHLOOHO:
Ho ja tsoekere ka makhetlo a mangata, ho ile ha baka boemo boo ho bona mohanyetsi oa opioid a ileng a baka matšoao a boitšoaro le a methapo a ho khaotsa opioid. Mehopolo ea matšoenyeho le ho se leka-lekane ha DA / ACh ho ne ho tšoana hantle le ho tlohela morphine kapa nicotine, ho fana ka maikutlo a hore likhoto li se li thehiloe tsoekere.
;
